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The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat

  • Reproductive Medicine
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Abstract

Background

This study was conducted to evaluate the effect of interaction of sympathetic and opioid systems in the processing of polycystic ovary syndrome modeling in rat.

Methods

Ninety adult female rats (7–8 weeks of age) were treated with EV for 60 days for induction of follicular cysts (PCO modeling). Clonidine and yohimbine were used for sympathic agonist and antagonist and nalterxone was used for opioid system inhibition. Interactions of two systems were studied.

Results

Our results indicate that both systems and interaction of two systems are effective in processing modeling of PCOS in rat. Interaction of two system drugs decreased estradiol (P < 0.05). Qualitative analysis showed that the bulk of cysts and corpus lutea and dominant follicles were increased in PCO rats in comparison with control group.

Conclusion

Therefore there could been an alternative in the treatment of the polycystic ovary syndrome in the rat by using adrenergic agonist and antagonists in combination with naltrexone.

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Authors and Affiliations

  1. Vali-e-Asr, Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Farideh Zafari Zangeneh

  2. Medicine Faculty, Azad University, Tehran, Iran

    A. Mohammadi

  3. Pharmacology Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran

    Sh. Ejtemaeimehr

  4. Central Biostatistics, Fasa University of Medical Sciences, Fasa, Iran

    Mohammad Mahdi Naghizadeh

  5. Veterinary Faculty, Tehran University, Tehran, Iran

    Aminee Fatemeh

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  1. Farideh Zafari Zangeneh
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Correspondence to Farideh Zafari Zangeneh.

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Zangeneh, F.Z., Mohammadi, A., Ejtemaeimehr, S. et al. The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat. Arch Gynecol Obstet 283, 885–892 (2011). https://doi.org/10.1007/s00404-010-1776-7

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  • DOI: https://doi.org/10.1007/s00404-010-1776-7

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