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Hepatic resection as part of secondary cytoreductive surgery for recurrent ovarian cancer involving the liver

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The aims of this study were to assess the surgical outcomes and to also determine the prognostic factors in patients with surgically resectable liver metastases for recurrent ovarian cancer.

Methods

Between 1991 and 2008, 18 patients with recurrent ovarian cancer who underwent hepatic resection as part of secondary cytoreductive surgery were identified from the tumor registry pathology database. Parameters for safety, efficacy, and survival data were considered as primary endpoints.

Results

Hepatic resections included wedge resection (n = 4), unisegmentectomy (n = 13), and bisegmentectomy (n = 1). There were no surgery-related deaths. Only one patient (5.6%) had postoperative major complications. The median postoperative hospitalization was 15.5 days (range 11–46 days). The prognostic factors associated with improved survival were less abdominal than pelvic disease (38 vs. 11 months, P = 0.032), optimal cytoreduction (40 vs. 9 months, P = 0.0004), and negative margin status of the hepatic resection (40 vs. 9 months, P = 0.0196). The overall median survival after hepatic resection was 38 months (range 3–78 months).

Conclusion

Hepatic resection for recurrent ovarian cancer is safe and is associated with a favorable outcome. Parenchymal liver metastases should not exclude attempts at optimal secondary cytoreductive surgery, and especially, patients with solitary liver metastases should be considered for hepatic resection.

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Republic of Korea

    Hyun-Jin Roh, Won-Duk Joo & Hang-Jo Yoo

  2. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-2dong, Songpa-Gu, Seoul, 138-736, Republic of Korea

    Dae-Yeon Kim, Jong-Hyeuk Kim, Yong-Man Kim, Young-Tak Kim & Joo-Hyun Nam

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  1. Hyun-Jin Roh
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  2. Dae-Yeon Kim
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Correspondence to Dae-Yeon Kim.

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Roh, HJ., Kim, DY., Joo, WD. et al. Hepatic resection as part of secondary cytoreductive surgery for recurrent ovarian cancer involving the liver. Arch Gynecol Obstet 284, 1223–1229 (2011). https://doi.org/10.1007/s00404-010-1750-4

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  • DOI: https://doi.org/10.1007/s00404-010-1750-4

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