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Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran

  • Materno-fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

There is conflicting data regarding leptin in gestational diabetes mellitus (GDM). The aim of the present study was to compare serum leptin levels between individuals with GDM and normal pregnancy.

Methods

This case–control study was performed on 26 GDM and 22 healthy pregnant women. Leptin concentrations were measured using an enzyme immunoassay.

Results

The level of serum leptin was not significantly different between GDM (9.890 ± 7.764 ng/ml) and normal pregnant women (13.80 ± 10.32 ng/ml) (p = 0.14).

Conclusion

There are no significant differences between GDM and normal pregnant women regarding leptin levels.

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References

  1. Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA (1991) Longitudinal changes in insulin release and insulin resistance in non-obese pregnant women. Am J Obstet Gynecol 165:1667–1672

    PubMed  CAS  Google Scholar 

  2. Ryan EA, Enns L (1988) Role of gestational hormones in the induction of insulin resistance. J Clin Endocrinol Metab 67:341–347

    Article  PubMed  CAS  Google Scholar 

  3. Henson MC, Castracane VD (2006) Leptin in pregnancy: an update. Biol Reprod 74:218–229

    Article  PubMed  CAS  Google Scholar 

  4. Kautzky-Willer A, Pacini G, Tura A, Bieglmayer C, Schneider B, Ludvik B, Prager R, Waldhausl W (2001) Increased plasma leptin in gestational diabetes. Diabetologia 44:164–172

    Article  PubMed  CAS  Google Scholar 

  5. Gao XL, Yang HX, Zhao Y (2008) Variations of tumor necrosis factor-alpha, leptin and adiponectin in mid-trimester of gestational diabetes mellitus. Chin Med J (Engl) 121:701–705

    CAS  Google Scholar 

  6. McLachlan KA, O’Neal D, Jenkins A, Alford FP (2006) Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? studies in women with and without gestational diabetes, during and after pregnancy. Diabetes Metab Res Rev 22:131–138

    Article  PubMed  CAS  Google Scholar 

  7. Festa A, Shnawa N, Krugluger W, Hopmeier P, Schernthaner G, Haffner SM (1999) Relative hypoleptinaemia in women with mild gestational diabetes mellitus. Diabet Med 16:656–662

    Article  PubMed  CAS  Google Scholar 

  8. Simmons D, Breier BH (2002) Fetal overnutrition in polynesian pregnancies and in gestational diabetes may lead to dysregulation of the adipoinsular axis in offspring. Diabetes Care 25:1539–1544

    Article  PubMed  Google Scholar 

  9. Mokhtari M, Hashemi M, Yaghmaei M, Molashahi F, Shikhzadeh A, Niazi A, Ghavami S (2010) Serum adenosine deaminase activity in gestational diabetes mellitus and normal pregnancy. Arch Gynecol Obstet 281:623–626

    Article  PubMed  CAS  Google Scholar 

  10. Yaghmaei M, Hashemi M, Shikhzadeh A, Mokhtari M, Niazi A, Ghavami S (2009) Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus. Diabetes Res Clin Pract 84:201–204

    Article  PubMed  CAS  Google Scholar 

  11. Yilmaz O, Kucuk M, Ilgin A, Dagdelen M (2010) Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. J Diabetes Complications 24:109–114

    Article  PubMed  Google Scholar 

  12. Cseh K, Baranyi E, Melczer Z, Csakany GM, Speer G, Kovacs M, Gero G, Karadi I, Winkler G (2002) The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. Gynecol Endocrinol 16:453–460

    PubMed  CAS  Google Scholar 

  13. Sivan E, Whittaker PG, Sinha D, Homko CJ, Lin M, Reece EA, Boden G (1998) Leptin in human pregnancy: the relationship with gestational hormones. Am J Obstet Gynecol 179:1128–1132

    Article  PubMed  CAS  Google Scholar 

  14. Stock SM, Bremme KA (1998) Elevation of plasma leptin levels during pregnancy in normal and diabetic women. Metabolism 47:840–843

    Article  PubMed  CAS  Google Scholar 

  15. Garcia-Arencibia M, Molero S, Davila N, Carranza MC, Calle C (2005) 17beta-Estradiol transcriptionally represses human insulin receptor gene expression causing cellular insulin resistance. Leuk Res 29:79–87

    Article  PubMed  CAS  Google Scholar 

  16. Collison M, Campbell IW, Salt IP, Dominiczak AF, Connell JM, Lyall H, Gould GW (2000) Sex hormones induce insulin resistance in 3T3–L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia 43:1374–1380

    Article  PubMed  CAS  Google Scholar 

  17. Buren J, Liu HX, Jensen J, Eriksson JW (2002) Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol 146:419–429

    Article  PubMed  CAS  Google Scholar 

  18. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432

    Article  PubMed  CAS  Google Scholar 

  19. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 94:8878–8883

    Article  PubMed  CAS  Google Scholar 

  20. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546–549

    Article  PubMed  CAS  Google Scholar 

  21. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ, Weigle DS (1996) Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531–535

    Article  PubMed  CAS  Google Scholar 

  22. Banerji MA, Faridi N, Atluri R, Chaiken RL, Lebovitz HE (1999) Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab 84:137–144

    Article  PubMed  CAS  Google Scholar 

  23. Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH, Kahn SE (2002) The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 51:1005–1015

    Article  PubMed  CAS  Google Scholar 

  24. Fernandez-Real JM, Gutierrez C, Ricart W, Casamitjana R, Fernandez-Castaner M, Vendrell J, Richart C, Soler J (1997) The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels. Diabetes 46:1468–1472

    Article  PubMed  CAS  Google Scholar 

  25. Henson MC, Castracane VD (2000) Leptin in pregnancy. Biol Reprod 63:1219–1228

    Article  PubMed  CAS  Google Scholar 

  26. Henson MC, Castracane VD (2002) Leptin: roles and regulation in primate pregnancy. Semin Reprod Med 20:113–122

    Article  PubMed  CAS  Google Scholar 

  27. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, Nakao K (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3:1029–1033

    Article  PubMed  CAS  Google Scholar 

  28. Toth B, Fischl A, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U (2009) Insulin and leptin receptors as possible new candidates for endocrine control in normal and disturbed human pregnancy. Mol Hum Reprod 15:231–239

    Article  PubMed  CAS  Google Scholar 

  29. Adali E, Yildizhan R, Kolusari A, Kurdoglu M, Bugdayci G, Sahin HG, Kamaci M (2009) Increased visfatin and leptin in pregnancies complicated by pre-eclampsia. J Matern Fetal Neonatal Med 1:1–7

    Google Scholar 

  30. Lewandowski K, Randeva HS, O’Callaghan CJ, Horn R, Medley GF, Hillhouse EW, Brabant G, O’Hare P (2001) Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin. Clin Endocrinol (Oxf) 54:533–539

    Article  CAS  Google Scholar 

  31. Kleiblova P, Dostalova I, Bartlova M, Lacinova Z, Ticha I, Krejci V, Springer D, Kleibl Z, Haluzik M (2010) Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus. Mol Cell Endocrinol 314:150–156

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by research grant from Zahedan University of Medical Sciences. The authors would like to acknowledge the patients and healthy subjects who willingly participated in the study.

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Correspondence to Mohammad Hashemi.

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Mokhtari, M., Hashemi, M., Yaghmaei, M. et al. Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran. Arch Gynecol Obstet 284, 539–542 (2011). https://doi.org/10.1007/s00404-010-1681-0

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  • DOI: https://doi.org/10.1007/s00404-010-1681-0

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