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Minimizing tumor burden by extensive cytoreductive surgery decreases postoperative venous thromboembolism in ovarian clear cell carcinoma

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Abstract

Purpose

A venous thromboembolism (VTE) is prevalent in patients with ovarian clear cell carcinoma (OCCC). Tumor burden and extensive cytoreductive surgery are well-known risk factor for a VTE. The purpose of this study was to define the incidence of VTE after extensive cytoreductive surgery and to clarify the relationship between VTE and extensive cytoreductive surgery in patients with OCCC.

Methods

We reviewed the medical charts of 43 patients treated at the National Cancer Center between June 2000 and July 2007. Most surgical procedures were performed with peri-operative thrmoboprophylaxis.

Results

Eight (18.6%) patients had deep vein thromboses and three of eight patients had a pulmonary thromboembolism. A VTE was identified at initial presentation in four patients, at recurrence in one patient, and during 3rd line chemotherapy in three patients when the patients had a bulky tumor burden. The rate of optimal debulking surgery was 95.3% and no patient had a VTE during the postoperative recovery period and adjuvant chemotherapy. A VTE was associated with disease status only (P = 0.042).

Conclusion

Minimizing residual tumor by extensive cytoreductive surgery with peri-operative thromboprophylaxis may decrease the incidence of a postoperative VTE in patients with OCCC. Larger, prospective studies are needed to confirm these preliminary findings.

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Acknowledgments

This work was supported by grants from the Korean National Cancer Center (0710200-3 and 0710210-3) and by a graduate research scholarship from Kyung Hee University, Seoul, Korea.

Conflict of interest statement

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 111 Jungbalsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Korea

    Myong Cheol Lim, Sokbom Kang, Sang-Soo Seo & Sang-Yoon Park

  2. Department of Obstetrics and Gynecology, Kyung Hee University Medical College, Seoul, Korea

    Myong Cheol Lim & Bo Yon Lee

  3. Center for Lung Cancer, Research Institute and Hospital, National cancer Center, Goyang, Gyeonggi, Korea

    Hee Seok Lee

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  1. Myong Cheol Lim
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Correspondence to Sang-Yoon Park.

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Lim, M.C., Lee, H.S., Kang, S. et al. Minimizing tumor burden by extensive cytoreductive surgery decreases postoperative venous thromboembolism in ovarian clear cell carcinoma. Arch Gynecol Obstet 281, 329–334 (2010). https://doi.org/10.1007/s00404-009-1120-2

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  • DOI: https://doi.org/10.1007/s00404-009-1120-2

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