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OC-125 immunostaining in endometriotic lesion samples

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Abstract

Purpose

To determine the presence of OC-125 staining in endometriotic lesions and to verify whether there is an association with endometriosis stage.

Methods

Thirteen patients from the Family Planning programs (group I) and 53 patients from the Chronic Pelvic Pain outpatient clinic (group II) were studied. Endometriotic lesions were excised from areas of endometriosis incidence and studied by histopathological assay and by immunohistochemistry for OC-125 staining.

Results

The histopathological study disclosed that all patients from group I had minimal/mild endometriosis. In group II, 39.6% had minimal/mild endometriosis, and 60.4% had moderate/severe endometriosis. OC-125 staining was negative in all samples from group I. In group II, OC-125 staining was positive in 52.4% patients with minimal/mild endometriosis and in 81.2% with moderate/severe endometriosis.

Conclusion

The data suggest that the OC-125 antibody is probably related to endometriosis activity and, consequently, to the progression and severity of the illness.

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Authors and Affiliations

  1. Disciplina de Genética e Reprodução Humana, Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina do ABC, FMABC, Avenida Príncipe de Gales, 821, Prédio CEPES, 2°. Andar, Santo André, São Paulo, CEP 09060-650, Brazil

    Caio Parente Barbosa, Ângela Mara Bentes de Souza, Bianca Bianco, Denise Maria Christofolini & Fernanda Abani Mafra

  2. Division of Gynecology, Department of Gynecology, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

    Geraldo Rodrigues de Lima

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  1. Caio Parente Barbosa
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  2. Ângela Mara Bentes de Souza
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  3. Bianca Bianco
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  4. Denise Maria Christofolini
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  6. Geraldo Rodrigues de Lima
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Correspondence to Caio Parente Barbosa.

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Barbosa, C.P., de Souza, Â.M.B., Bianco, B. et al. OC-125 immunostaining in endometriotic lesion samples. Arch Gynecol Obstet 281, 43–47 (2010). https://doi.org/10.1007/s00404-009-1055-7

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  • DOI: https://doi.org/10.1007/s00404-009-1055-7

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