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Venous thrombembolism, thrombophilic defects, combined oral contraception and anticoagulation

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Abstract

Background

Several genetic polymorphisms increase the risk for venous thrombembolism (VTE). In particular, combined oral contraceptives (COCs) are known to enhance the risk for VTE and are therefore contraindicated.

Case

We present here the case of a patient with protein S deficiency, who has used COCs together with anticoagulatory therapy (Phenprocoumon) after suffering from deep venous thromboses for 4 years. At the time of her first consultation at our clinic, the ultrasound examination showed a complete involution of her venous thrombosis.

Conclusion

COCs can be used in patients with thrombogenic mutations and anticoagulatory therapy in individual cases.

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Authors and Affiliations

  1. Department of Gynaecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria

    Johannes Ott, Ulrike Kaufmann, Johannes C. Huber & Peter Frigo

  2. Department of Surgery, Medical University Vienna, Vienna, Austria

    Regina Promberger

  3. Department of Gynaecology and Obstetrics, Medical University Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria

    Johannes Ott

Authors
  1. Johannes Ott
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  2. Regina Promberger
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  3. Ulrike Kaufmann
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  4. Johannes C. Huber
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  5. Peter Frigo
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Correspondence to Johannes Ott.

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Ott, J., Promberger, R., Kaufmann, U. et al. Venous thrombembolism, thrombophilic defects, combined oral contraception and anticoagulation. Arch Gynecol Obstet 280, 811–814 (2009). https://doi.org/10.1007/s00404-009-0997-0

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  • DOI: https://doi.org/10.1007/s00404-009-0997-0

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