Skip to main content

Advertisement

SpringerLink
Log in

A unique case of ovarian psammocarcinoma with mediastinal, pulmonary, subcutaneous, and omental metastases

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Psammocarcinoma is a rare form of serous ovarian and peritoneal carcinoma, characterized by abundant psammoma bodies, invasiveness, and low-grade cytological features. Many of the cases which have been reported had extraovarian spread and peritoneal seeding at the time of presentation. We present a case of 45-year-old woman with ovarian psammocarcinoma who initially presented with a metastatic subcutaneous nodule, and was found to have pulmonary and mediastinal metastases. We believe this to be the first report of a psammocarcinoma with these metastases. Ovarian and peritoneal psammocarcinomas are quite rare, and because of this, knowledge of their behavior is limited. Although most seem to follow an indolent course similar to that of borderline lesions of the ovary, this case demonstrates that some of these tumors may be clinically aggressive with distant metastases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Gilks CB, Bell DA, Scully RE (1990) Serous psammocarcinoma of the ovary and the peritoneum. Int J Gynecol Pathol 9:110–121. doi:10.1097/00004347-199004000-00002

    Article  PubMed  CAS  Google Scholar 

  2. Chen KTK (1994) Psammocarcinoma of the peritoneum. Diagn Cytopathol 10:224–228. doi:10.1002/dc.2840100307

    Article  PubMed  CAS  Google Scholar 

  3. Giordano G, Gnetti L, Milione M, Piccolo D, Soliani P (2005) Serous psammocarcinoma of the ovary: a case report and review of the literature. Gynecol Oncol 96:259–262. doi:10.1016/j.ygyno.2004.09.054

    Article  PubMed  Google Scholar 

  4. Molpus K, Wu H, Fuller A (1998) Recurrent psammocarcinoma of the peritoneum with complete response to tamoxifen therapy. Gynecol Oncol 68:206–209. doi:10.1006/gyno.1997.4908

    Article  PubMed  CAS  Google Scholar 

  5. Koumoundourou D, Michail G, Kourounis G, Ravazoula P (2006) Primary peritoneal psammocarcinoma: a case presenting synchronously with bowel carcinoma. Gynecol Oncol 102:576–579. doi:10.1016/j.ygyno.2006.02.040

    Article  PubMed  CAS  Google Scholar 

  6. Vimplis S, Williamson KM, Chaudry Z, Nunns D (2006) Psammocarcinoma of the ovary: a case report and review of the literature. Gynecol Surg 3:55–57. doi:10.1007/s10397-005-0165-x

    Article  Google Scholar 

  7. Poggi S, Bristow R, Nieberg R, Berek J (1998) Psammocarcinoma with an aggressive course. J Am Coll Obst Gynecol 92:659–661

    CAS  Google Scholar 

  8. Bilgin T, Ozuysal S, Cankilic H (2006) Primary psammocarcinoma of the peritoneum. Int J Gynecol Cancer 16:129–131. doi:10.1111/j.1525-1438.2006.00320.x

    Article  PubMed  Google Scholar 

  9. Pusiol T, Parolari A, Piscioli I, Morelli L, Del Nonno F, Licci S (2008) Prevalence and significance of psammoma bodies in cervicovaginal smears in a cervical cancer screening program with emphasis on a case of primary bilateral ovarian psammocarcinoma. Cytojournal 5:7. doi:10.1186/1742-6413-5-7

    Article  PubMed  Google Scholar 

  10. Akbulut M, Kelten C, Bir F, Soysal M, Duzcan S (2007) Primary peritoneal serous psammocarcinoma with recurrent disease and metastasis: a case report and review of the literature. Gynecol Oncol 105:248–251. doi:10.1016/j.ygyno.2006.11.024

    Article  PubMed  Google Scholar 

  11. Cobellis L, Pezzani I, Cataldi P, Bome A, Santopietro R, Petraglia F (2003) Ovarian psammocarcinoma with peritoneal implants. Eur J Obstet Gynecol Reprod Biol 107:217–219. doi:10.1016/S0301-2115(02)00340-8

    Article  PubMed  Google Scholar 

  12. Munkarah A, Jacques S, Qureshi F, Deppe G (1999) Conservative surgery in a young patient with peritoneal psammocarcinoma. Gynecol Oncol 73:312–314. doi:10.1006/gyno.1998.5306

    Article  PubMed  CAS  Google Scholar 

  13. Whitcomb B, Kost E, Hines J, Zahn C, Hall K (1999) Primary peritoneal psammocarcinoma: a case presenting with an upper abdominal mass and elevated CA-125. Gynecol Oncol 73:331–334. doi:10.1006/gyno.1998.5309

    Article  PubMed  CAS  Google Scholar 

  14. Sieben N, Macropoulos P, Roemen G, Kolkman-Uljee S, Fleuren G, Houmadi R, Diss T, Warren B, Al Adnani M, de Goeij A, Krausz T, Flanagan A (2004) In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 202:336–340. doi:10.1002/path.1521

    Article  PubMed  CAS  Google Scholar 

  15. Rettenmaier M, Goldstein B, Epstein H, Brown J III, Micha J (2005) Serous psammocarcinoma of the ovary: an unusual finding. Gynecol Oncol 99:510–511. doi:10.1016/j.ygyno.2005.06.042

    Article  PubMed  Google Scholar 

  16. Reboul J, Delorme G, Mas JP, Geindre M (1961) Calcification des metastases abdominals d’une tumeur ovarienne (psammocarcinome). J Med Bord 138:790–792

    PubMed  CAS  Google Scholar 

  17. Koischwitz D (1974) Das metastasierende psammokarzinom des ovars. Fortschr Geb Rontgenstr Nuklearmed 120(3):357–360

    Article  PubMed  CAS  Google Scholar 

  18. Moussa A, Denguezli W, Njim L, Haddad A, Faleh R, Sakouhi M, Zakhama A (2007) Skin metastases revealing a bilateral ovarian invasive micropapillary serous carcinoma. Arch Gynecol Obstet 278:71–74. doi:10.1007/s00404-007-0519-x

    Article  PubMed  Google Scholar 

Download references

Conflict of interest statement

The authors declare that there are no conflicts of interest. The authors declare that no financial support was received for this article.

Author information

Authors and Affiliations

  1. Department of Surgery, Western Reserve Care System/Northeast Ohio Universities College of Medicine, 500 Gypsy Lane, Youngstown, OH, 44505, USA

    Daniel M. Chase, Dorothy A. Sparks & James Smith

  2. Department of Pathology, Western Reserve Care System/Northeast Ohio Universities College of Medicine, 500 Gypsy Lane, Youngstown, OH, 44505, USA

    Melissa Gener

Authors
  1. Daniel M. Chase
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dorothy A. Sparks
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Melissa Gener
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. James Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dorothy A. Sparks.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chase, D.M., Sparks, D.A., Gener, M. et al. A unique case of ovarian psammocarcinoma with mediastinal, pulmonary, subcutaneous, and omental metastases. Arch Gynecol Obstet 280, 283–286 (2009). https://doi.org/10.1007/s00404-008-0883-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-008-0883-1

Keywords

Search

Navigation