Skip to main content
SpringerLink
Log in

Serous psammocarcinoma of the ovary and peritoneum: two case reports and review of the literature

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Serous psammocarcinoma (SPC) is a rare variant of ovarian carcinoma or peritoneum that may present with features consistent with malignancy, or tumors of low malignant potential. This is two-case reports of a SPC of the ovary and peritoneum and review of the literature. A 41-year-old woman was referred to our clinic for adnexal mass. Ultrasonography revealed endometrioma. Endometriotic cyst excision and sacrouterine biopsy were performed via laparoscopy. Histological examination revealed endometrioma and psammocarcinoma of the peritoneum. Staging laparotomy was performed. She received six courses of chemotherapy. She has no evidence of disease after 6 years from surgical therapy and chemotherapy. A 50-year-old woman presented with pelvic pain and discomfort in the upper abdomen with nausea and emesis. CT scan showed extensive tumor in the lower abdomen, and free fluid in the abdomen and pelvis which appeared to be an ovarian tumor. She underwent a laparotomy and a right and left ovarian tumor measuring about 20 × 15 and 8 × 8 cm, respectively, were seen. Staging procedure was performed. Microscopic examination revealed SPC of the ovary. Chemotherapy was planned. The biologic behavior of this disease remains unresolved. Primary surgical debulking should be attempted, while the utility of postoperative chemotherapy remains unknown.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Gilks CB, Bell DA, Scully RE (1990) Serous psammocarcinoma of the ovary and peritoneum. Int J Gynecol Pathol 9:110–121

    Article  PubMed  CAS  Google Scholar 

  2. Molpus KL, Wu H, Fuller AF (1998) Recurrent psammocarcinoma of the peritoneum with complete response to tamoxifen therapy. Gynecol Oncol 68:206–209. doi:10.1006/gyno.1997.4908

    Article  PubMed  CAS  Google Scholar 

  3. Koumondorou D, Michail G, Kourounis G, Ravazoula P (2006) Primary peritoneal psammocarcinoma: a case presenting synchronously with bowel carcinoma. Gynecol Oncol 102:576–579. doi:10.1016/j.ygyno.2006.02.040

    Article  Google Scholar 

  4. Bilgin T, Ozuysal S, Cankılıc H (2006) Primary psammocarcinoma of the peritoneum. Int J Gynecol Cancer 16:129–131. doi:10.1111/j.1525-1438.2006.00320.x

    Article  PubMed  Google Scholar 

  5. Poggi SH, Bristow RE, Nieberg RK, Berek JS (1998) Psammocarcinoma with aggressive course. Obstet Gynecol 92:659–661. doi:10.1016/S0029-7844(98)00028-3

    Article  PubMed  CAS  Google Scholar 

  6. Scully ES, Clement PB, Young RA (2004) Ovarian surface epithelial-stromal tumors. In: Mills SE et al (eds) Sternberg’s diagnostic aurgical pathology. Lippincott Williams and Wilkins, Philadelphia, p 2544

    Google Scholar 

  7. Körner M, Burckhardt E, Mazzucchelli L (2005) Different proportions of aneusomic cells in ovarian inclusion cysts associated with serous borderline tumours and serous high-grade carcinomas support different pathogenetic pathways. J Pathol 207:20–26. doi:10.1002/path.1817

    Article  PubMed  Google Scholar 

  8. Sieben NL, Macropoulos P, Roemen GM et al (2004) In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 202:336–340. doi:10.1002/path.1521

    Article  PubMed  CAS  Google Scholar 

  9. Pakos E, Funke A, Tschubel K, Pfeifer U (1997) Serous psammocarcinoma of the ovary. Case report and literature review. Pathologe 18:463–466. doi:10.1007/s002920050243

    Article  PubMed  CAS  Google Scholar 

  10. Kuhn W, Kaufman M, Feichter GE, Rummel HH, Schmid H, Heberling D (1989) DNA flow cytometry, clinical and morphological parameters as prognostic factors for advanced malignant and borderline ovarian tumors. Gynecol Oncol 33:360–367. doi:10.1016/0090-8258(89)90528-3

    Article  PubMed  CAS  Google Scholar 

  11. Weir MM, Bell DA, Young RH (1998) Grade I peritoneal serous carcinomas: a report of 14 cases and comparison with 7 peritoneal serous psammocarcinomas and 19 peritoneal serous borderline tumors. Am J Surg Pathol 22:849–862. doi:10.1097/00000478-199807000-00007

    Article  PubMed  CAS  Google Scholar 

  12. Whitcomb BP, Kost ER, Hines JF, Zahn CM, Hall KL (1999) Primary peritoneal psammocarcinoma: a case presenting with upper abdominal mass and elevated CA-125. Gynecol Oncol 73:331–334. doi:10.1006/gyno.1998.5309

    Article  PubMed  CAS  Google Scholar 

  13. Munkarah AR, Jacques SM, Qureshi F, Deppe G (1999) Conservative surgery in a young woman with peritoneal psammocarcinoma. Gynecol Oncol 73:312–314. doi:10.1006/gyno.1998.5306

    Article  PubMed  CAS  Google Scholar 

  14. Koischwitz D (1974) Metastasizing psammocarcinoma ovary. Fortschr Geb Rontgenstr Nuklearmed 120:357–360

    Article  PubMed  CAS  Google Scholar 

  15. Vajda D, Maurer P, Madarasz M (1968) Psammocarcinoma of the ovary. Radiol Diagn (Berl) 9:557–563

    CAS  Google Scholar 

  16. Reboul J, Delorme G, Mas JP, Geindre M (1961) Calcification of the abdominal metastases of an ovarian tumor (psammocarcinoma). J Med Bord 138:790–792

    PubMed  CAS  Google Scholar 

  17. Radin A, Youssef IM, Quimbo RD, Perone RW, Guerrieri C, Abdel-Dayem HM (2005) Technetium-99 m diphosphonate imaging of psammocarcinoma of probable ovarian origin. Case report and literature review. Clin Nucl Med 30:395–399. doi:10.1097/01.rlu.0000162604.51925.5e

    Article  PubMed  Google Scholar 

  18. Akbulut M, Kelten C, Bir F, Soysal ME, Duzcan SE (2007) Primary peritoneal serous psammocarcinoma with recurrent disease and metastasis: a case report and review of the literature. Gynecol Oncol 105:248–251. doi:10.1016/j.ygyno.2006.11.024

    Article  PubMed  Google Scholar 

  19. Kelley JL, Capelle SC, Kanbour-Shakir A (1995) Serous psammocarcinoma of the ovary in adolescent female. Gynecol Oncol 59:309–311. doi:10.1006/gyno.1995.0028

    Article  PubMed  CAS  Google Scholar 

  20. Powell JL, McDonald TJ, White WC (1998) Serous psammocarcinoma of the ovary. South Med J 91:477–480

    PubMed  CAS  Google Scholar 

  21. Cobellis L, Pezzani I, Castaldi P, Bome A, Santopietro R, Petraglia F (2003) Ovarian psammocarcinoma with peritoneal implants. Eur J Obstet Gynecol Reprod Biol 107:217–219. doi:10.1016/S0301-2115(02)00340-8

    Article  PubMed  Google Scholar 

  22. Giordano G, Gnetti L, Milione M, Piccolo D, Soliani P (2005) Serous psammocarcinoma of the ovary: a case report and review of literature. Gynecol Oncol 96:259–262. doi:10.1016/j.ygyno.2004.09.054

    Article  PubMed  Google Scholar 

  23. Rettenmaier MA, Goldstein BH, Epstein HD, Brown JV, Micha JP (2005) Serous psammocarcinoma of the ovary: an unusual finding. Gynecol Oncol 99:510–511. doi:10.1016/j.ygyno.2005.06.042

    Article  PubMed  Google Scholar 

  24. Hiromura T, Tanaka YO, Nishioka T, Tomita K (2007) Serous psammocarcinoma of the ovary: CT and MR findings. J Comput Assist Tomogr 31:490–492. doi:10.1097/01.rct.0000243450.48857.3a

    Article  PubMed  Google Scholar 

  25. Pusiol T, Parolari AM, Piscioli I, Morelli L, Del Nonno F, Licci S (2008) Prevalence and significance of psammoma bodies in cervicovaginal smears in a cervical cancer screening program with emphasis on a case of primary bilateral ovarian psammocarcinoma. Cytojournal 16:5–7

    Google Scholar 

  26. McCaughey WT, Schryer MJ, Lin X, Al-Jabi M (1986) Extraovarian pelvic serous tumor with marked calcification. Arch Pathol Lab Med 110:78–80

    PubMed  CAS  Google Scholar 

  27. Chen KT (1994) Psammocarcinoma of the peritoneum. Diagn Cytopathol 10:224–228. doi:10.1002/dc.2840100307

    Article  PubMed  CAS  Google Scholar 

  28. Lehner R, Jaindl M, Wenzl R, Jirecek SG, Stengg K, Sevelda P (1998) Psammocarcinoma of the peritoneum diagnosed during operative laparoscopy. Acta Obstet Gynecol Scand 77:870–871

    PubMed  CAS  Google Scholar 

  29. Piura B, Rabinovich A, Yanai-Inbar I (2001) Psammomacarcinoma of the peritoneum. Eur J Obstet Gynecol Reprod Biol 97:231–234. doi:10.1016/S0301-2115(00)00508-X

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest statement

None of the authors has any potential conflict of interest.

Author information

Authors and Affiliations

  1. Gülhane Military Medical Academy, Obstetrics and Gynecology, Ankara, Turkey

    İbrahim Alanbay, Murat Dede, Yusuf Üstün, Emre Karaşahin & Müfit Cemal Yenen

  2. Gülhane Military Medical Academy, Pathology, Ankara, Turkey

    Salih Deveci & Ömer Günhan

  3. GATA Kadın Hastalıkları ve Doğum Anabilim Dalı, 06018, Etlik/Ankara, Turkey

    Yusuf Üstün

Authors
  1. İbrahim Alanbay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Murat Dede
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yusuf Üstün
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Emre Karaşahin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Salih Deveci
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ömer Günhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Müfit Cemal Yenen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yusuf Üstün.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Alanbay, İ., Dede, M., Üstün, Y. et al. Serous psammocarcinoma of the ovary and peritoneum: two case reports and review of the literature. Arch Gynecol Obstet 279, 931–936 (2009). https://doi.org/10.1007/s00404-008-0826-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-008-0826-x

Keywords

Search

Navigation