Skip to main content

Advertisement

SpringerLink
Log in

Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics

  • Short Communication
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon primary malignancy of the peritoneum. The aim of our study is to present the characteristics of such a rare entity through our case series.

Method

This is a retrospective study of nine cases of PPPSC who were treated between January 2002 and April 2007 in METAXA Memorial Cancer Hospital, Piraeus, Greece. Medical files and histopathological diagnosis of each patient were retrospectively studied.

Results

The median age of the patients was 63 years ranging from 44 up to 74 years. Clinically PPPSC presented with general abdominal discomfort in all of the patients. Three out of nine patients presented with constipation, 5/9 with distention, and 7/9 with ascites. All of the patients referred loss of appetite with weight gaining due to ascites. All the patients had pathological values of CA125 (over 35 U/ml) ranging from 125 up to 1,255 U/ml with median value 565 U/ml. Optimal debulking was possible in 3/9 of patients who were consequently treated with standard taxol-platin chemotherapy. Complete response was achieved in one woman. The median disease-free survival was 7 months and the median overall survival rate was 2.5 years.

Conclusion

PPPSC mimics ovarian papillary serous carcinoma regarding the clinical and laboratory characteristics but it has worse prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Eltabbakh G, Piver M, Natarajahn N, Mettlin C (1998) Epidemiologic differences between women with extraovarian primary peritoneal carcinoma and women with epithelial ovarian cancer. Obstet Gynecol 91:254–259. doi:10.1016/S0029-7844(97) 00650-9

    Article  PubMed  CAS  Google Scholar 

  2. Piek JM, Kenemans P, Verheijen RH (2004) Intraperitoneal serous adenocarcinoma: a critical appraisal of three hypotheses on its cause. Am J Obstet Gynecol 191:718–732. doi:10.1016/j.ajog.2004.02.067

    Article  PubMed  Google Scholar 

  3. Eltabbakh GH, Piver MS (1998) Extraovarian primary peritoneal carcinoma. Oncology 12:809–813

    Google Scholar 

  4. Eltabbakh GH, Piver MS, Natarajan N, Metlin CJ (1998) Epidemiologic differences between women with extraovarian primary peritoneal carcinoma and women with epithelial ovarian cancer. Obstet Gynecol 1:254–259. doi:10.1016/S0029-7844(97) 00650-9

    Article  Google Scholar 

  5. Chou CS, Menzin AW, Leonard DGB, Rubin SC, Wheeler E (1999) Primary peritoneal carcinoma: a review of the literature. Obstet Gynecol Surv 54:323–335. doi:10.1097/00006254-199905000-00023

    Article  Google Scholar 

  6. Swerdlow M (1959) Mesothelioma of the pelvic peritoneum resembling papillary cystadenocarcinoma of the ovary. Am J Obstet Gynecol 77:197–200

    PubMed  CAS  Google Scholar 

  7. Fowler JM, Nieberg RK, Schooler TA, Berek JS (1994) Peritoneal adenocarcinoma (serous) of Mullerian type: a subgroup of women presenting with peritoneal carcinomatosis. Int J Gynecol Cancer 4:43–51. doi:10.1046/j.1525-1438.1994.04010043.x

    Article  PubMed  Google Scholar 

  8. Bloss JD, Liao S-Y, Buller RE, Manetta A, Berman ML, McMeekin S et al (1993) Extraovarian peritoneal serous papillary carcinoma: a case-control retrospective comparison to papillary adenocarcinoma of the ovary. Gynecol Oncol 50:347–351. doi:10.1006/gyno.1993.1223

    Article  PubMed  CAS  Google Scholar 

  9. Jordan S et al (2007) Serous ovarian, fallopian tube, and primary peritoneal cancers: a comparative epidemiological analysis. Int J Cancer 122(7):1598–1603

    Google Scholar 

  10. Barda G, Menczer J, Chetrit A, Lubin F, Beck D, Piura P et al (2004) Comparison between primary peritoneal and epithelial ovarian carcinoma. A population based study. Am J Obstet Gynecol 190:1039–1045. doi:10.1016/j.ajog.2003.09.073

    Article  PubMed  Google Scholar 

  11. Fromm GL, Gershenson DM, Silva EG (1990) Papillary serous carcinoma of the peritoneum. Obstet Gynecol 75:75–89

    Google Scholar 

  12. Hunter RW, Alexander ND, Soutter WP (1992) Meta-analysis of surgery in advanced ovarian carcinoma: is maximum cytoreductive surgery an independent determinant of prognosis? Am J Obstet Gynecol 166:504–511

    PubMed  CAS  Google Scholar 

  13. Menczer J (1992) Cytoreductive surgery in the treatment of advanced ovarian carcinoma. Some controversial aspects. Eur J Gynaecol Oncol 13:246–255

    PubMed  CAS  Google Scholar 

  14. Covens AL (2000) A critique of surgical cytoreduction in advanced ovarian cancer. Gynecol Oncol 78:269–274. doi:10.1006/gyno.2000.5926

    Article  PubMed  CAS  Google Scholar 

  15. Dalrymple JC, Bannatyne P, Russell P et al (1989) Extraovarian peritoneal serous papillary carcinoma. A clinicopathologic study of 31 cases. Cancer 64:110–115. doi:10.1002/1097-0142(19890701)64:1≤110::AID-CNCR2820640120≥3.0.CO;2-5

    Google Scholar 

  16. Killackey MA, Davis AR (1993) Papillary serous carcinoma of the peritoneal surface: matched-case comparison with papillary serous ovarian carcinoma. Gynecol Oncol 51:171–174. doi:10.1006/gyno.1993.1267

    Article  PubMed  CAS  Google Scholar 

  17. Kowalski LD, Kanbour AI, Price FV et al (1997) A case-matched comparison of extraovarian versus primary ovarian adenocarcinoma. Cancer 79:1587–1594

    Google Scholar 

  18. Ransom DT, Patel SR, Keeney GL, Malkasian GD, Edmonson JH (1990) Papillary serous carcinoma of the peritoneum. A review of 33 cases treated with platin-based chemotherapy. Cancer 66:1091–1094. doi:10.1002/1097-0142(19900915)66:6≤1091::AID-CNCR2820660602≥3.0.CO;2-F

    Google Scholar 

  19. Piver MS, Eltabbakh GH, Hempling RE, Recio FO, Blumenson LE (1997) Two sequential studies for primary peritoneal carcinoma: induction with weekly cisplatin followed by either cisplatin-doxorubicincyclophosphamide or paclitaxel-cisplatin. Gynecol Oncol 67:141–146. doi:10.1006/gyno.1997.4843

    Article  PubMed  CAS  Google Scholar 

  20. White CD (1993) Papillary intraperitoneal neoplasia resembling ovarian carcinoma after removal of benign ovaries. W V Med J 89:282–283

    PubMed  CAS  Google Scholar 

  21. Dalrymple JC, Bannatyne P, Russel P, Solomon HJ, Tattersall MHN, Atkinson K et al (1989) Extraovarian peritoneal carcinoma. A clinicopathological study of 31 cases. Cancer 64:110–115. doi:10.1002/1097-0142(19890701)64:1≤110::AID-CNCR2820640120≥3.0.CO;2-5

    Google Scholar 

  22. Lele SB, Piver MS, Matharu J, Tsukadu Y (1988) Peritoneal papillary carcinoma. Gynecol Oncol 31:315–320. doi:10.1016/S0090-8258(88) 80010-6

    Article  PubMed  CAS  Google Scholar 

  23. Wick MR, Mills SE, Dehner LP, Bollinger DJ, Fechner RE (1989) Serous papillary carcinomas arising from the peritoneum and ovaries. A clinicopathologic and immunohistochemical comparison. Int J Gynecol Pathol 8:179–188. doi:10.1097/00004347-198909000-00001

    PubMed  CAS  Google Scholar 

  24. Ransom DT, Patel SR, Keeney GL, Malkasian GD (1990) Papillary serous carcinoma of the peritoneum: a review of 33 cases treated with platin based chemotherapy. Cancer 66:1091–1094. doi:10.1002/1097-0142(19900915)66:6≤1091::AID-CNCR2820660602≥3.0.CO;2-F

    Google Scholar 

  25. Altaras NM, Aviram R, Cohen I, Cordoba M, Weiss E, Beyth Y (1991) Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects. Gynecol Oncol 40:230–236. doi:10.1016/0090-8258(90) 90283-Q

    Article  PubMed  CAS  Google Scholar 

  26. Ben-Baruch G, Sivan E, Moran O, Rizel S, Menczer J, Seidman DS (1996) Primary peritoneal serous papillary carcinoma: a study of 25 cases and comparison with stage III–IV ovarian papillary serous carcinoma. Gynecol Oncol 60:393–396. doi:10.1006/gyno.1996.0060

    Article  PubMed  CAS  Google Scholar 

  27. Halperin R, Zehavi S, Langer R, Hadas E, Bukovski I, Schneider D (2001) Primary peritoneal serous papillary carcinoma: a new epidemiologic trend? A matched case comparison with ovarian serous papillary cancer. Int J Gynecol Cancer 11:403–408. doi:10.1046/j.1525-1438.2001.01027.x

    Article  PubMed  CAS  Google Scholar 

  28. Mulhollan TJ, Silva EG, Tornos C, Guerrieri C, Fromm GL, Gershenson D (1994) Ovarian involvement by serous surface papillary carcinoma. Int J Gynecol Pathol 13:120–126. doi:10.1097/00004347-199404000-00003

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gynecology, METAXA Memorial Cancer Hospital, Piraeus, Greece

    C. Iavazzo, G. Vorgias, M. Katsoulis, N. Kalinoglou, V. Dertimas & T. Akrivos

  2. 38, Seizani Str., Nea Ionia, 14231, Athens, Greece

    C. Iavazzo

Authors
  1. C. Iavazzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Vorgias
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Katsoulis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. Kalinoglou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. Dertimas
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. Akrivos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. Iavazzo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iavazzo, C., Vorgias, G., Katsoulis, M. et al. Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics. Arch Gynecol Obstet 278, 53–56 (2008). https://doi.org/10.1007/s00404-008-0678-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-008-0678-4

Keywords

Search

Navigation