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Can pentoxifylline improve the sperm motion and ICSI success in the primary ciliary dyskinesia?

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Abstract

Primary ciliary dyskinesia (PCD), previously known as immotile cilia syndrome, can cause respiratory and reproductive problems. Because of the impaired motion of microtubules the patients suffer upper respiratory tract problems. Infertility is an other issue of these patients. Several attempt have been proposed to bring back sperm motion and to improve intracytoplasmic sperm injection (ICSI) results. With our case we have described the management of a male infertility that causes from immotile cilia. The role of ICSI with incubated and activated ejaculatory sperm by pentoxifylline in the patient of PCD or as commonly named immotile cilia syndrome.

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References

  1. Ortega HA, Vega Nde A, Santos BQ, Maia GT (2007) Primary ciliary dyskinesia: considerations regarding six cases of Kartagener syndrome. J Bras Pneumol 33(5):602–608

    Article  PubMed  Google Scholar 

  2. Dombi VH, Walt H. (1996) Primary ciliary dyskinesia, immotile cilia syndrome, and Kartagener syndrome:diagnostic criteria. Schweiz Med Wochenschr 126(11):421–433

    PubMed  CAS  Google Scholar 

  3. Afzelius BA (1979) The immotile-cilia syndrome and other ciliary disease. Int Rev Exp Path 19:1–43

    PubMed  CAS  Google Scholar 

  4. Stalf T, Sánchez R, Köhn FM, Schalles U, Kleinstein J, Hinz V, Tielsch J, Khanaga O, Turley H, Gips H, Shill WB (1995) Pregnancy and birth after intracytoplasmic sperm injection with spermatozoa from a patient with tail stump syndrome. Hum Reprod 10(8):2112–2114

    PubMed  CAS  Google Scholar 

  5. Nassar A, Mahony M, Morshedi M, Lin MH, Srisombut C, Oehninger S (1999) Modulation of sperm tail protein tyrosine phosphorylation by pentoxifylline and its correlation with hyperactivated motility. Fertil Steril 71(5):919–923

    Article  PubMed  CAS  Google Scholar 

  6. Tasdemir I, Tasdemir M, Tavukcuoglu S (1998) Effect of pentoxifylline on immotile testicular spermatozoa. J Assist Reprod Genet 15:90–92

    Article  PubMed  CAS  Google Scholar 

  7. Negri P, Grechi E, Tomasi A, Fabbri E, Capuzzo A (1996) Effectiveness of pentoxifylline in semen preparation for intrauterine insemination. Hum Reprod 11:1236–1239

    PubMed  CAS  Google Scholar 

  8. Kovacic B, Vlaisavljevic V, Reljic M. (2006) Clinical use of pentoxifylline for activation of immotile testicular sperm before ICSI in patients with azoospermia. J Androl 27(1):45–52

    Article  PubMed  CAS  Google Scholar 

  9. Yovich JM, Edirisinghe WR, Cummins JM, Yovich JL (1990) Influence of pentoxifylline in severe male factor infertility. Fertil Steril 53:715–722

    PubMed  CAS  Google Scholar 

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Correspondence to Gazi Yildirim.

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Yildirim, G., Ficicioglu, C., Akcin, O. et al. Can pentoxifylline improve the sperm motion and ICSI success in the primary ciliary dyskinesia?. Arch Gynecol Obstet 279, 213–215 (2009). https://doi.org/10.1007/s00404-008-0671-y

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  • DOI: https://doi.org/10.1007/s00404-008-0671-y

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