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Maternal kidney stones during pregnancy and adverse birth outcomes, particularly congenital abnormalities in the offspring

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Abstract

Objective

The possible adverse birth outcomes, particularly congenital abnormalities (CAs) in pregnant women with kidney stones (KS) previously have not been evaluated; therefore, we decided to study this possible association.

Methods

The population-based data set of the Hungarian Case–Control Surveillance of CAs, 1980–1996, was used for this analysis.

Results

Of 22,843 newborns or fetuses with CAs, 69 (0.30%) had mothers with KS during pregnancy. Of 38,151 matched control newborns without any abnormalities, 147 (0.39%) had KS during pregnancy. KS were associated with an adjusted prevalence odds ratio (POR) with 95% CI of 0.8, 0.6–1.0 for CAs. A higher prevalence of maternal KS during the first trimester of pregnancy was not found in any CA group. There was no higher rate of preterm birth and low birthweight in the newborns of pregnant women with KS.

Conclusions

There is no higher risk for adverse birth outcomes particularly CAs in the offspring of mothers with KS and related drug treatments during pregnancy.

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References

  1. Moe OW (2006) Kidney stones: pathophysiology and medical management. Lancet 367:333–344

    Article  PubMed  CAS  Google Scholar 

  2. Pak CY (1998) Kidney stones. Lancet 351:1797–1801

    Article  PubMed  CAS  Google Scholar 

  3. Borghi L, Meschi T, Amato F, Brigant A, Novarini A, Giannini A (1996) Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5 year randomized prospective study. J Urol 155:839–844

    Article  PubMed  CAS  Google Scholar 

  4. Stamatelon KK, Francis ME, Jones CA, Nyberg LM, Curhan GC (2003) Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney Int 63:1817–1823

    Article  Google Scholar 

  5. Trinchieri A, Ostini F, Nespoli R, Rovera F, Zanetti G (1999) A prospective study of recurrence rate and risk factors for recurrence after a first renal stone. J Urol 162:27–30

    Article  PubMed  CAS  Google Scholar 

  6. Curhan GC, Willett WC, Knight EL, Stampfer MJ (2004) Dietary factors and risk of incident kidney stones in younger women: Nurses’ Health Study II. Arch Intern Med 164:885–891

    Article  PubMed  Google Scholar 

  7. Shepard TH, Lemire T (2004) Catalog of teratogenic agents, 11th edn. Johns Hopkins University Press, Baltimore

    Google Scholar 

  8. Czeizel AE, Rockenbauer M, Siffel CS, Varga E (2001) Description and mission evaluation of the Hungarian Case–Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology 63:176–185

    Article  PubMed  CAS  Google Scholar 

  9. Czeizel AE (1997) The first 25 years of the Hungarian Congenital Abnormality Registry. Teratology 55:299–305

    Article  PubMed  CAS  Google Scholar 

  10. Czeizel AE, Intódy ZS, Modell B (1993) What proportion of congenital abnormalities can be prevented? Brit Med J 306:499–503

    Article  PubMed  CAS  Google Scholar 

  11. Czeizel AE, Petik D, Vargha P (2003) Validation studies of drug exposures in pregnant women. Pharmacoepidemiol Drug Saf 12:409–416

    Article  PubMed  CAS  Google Scholar 

  12. Soucie JM, Thun MJ, Coates RK, McClellan W, Austin H (1994) Demographic and geographic variability of kidney stones in the United States. Kidney Int 46:893–895

    PubMed  CAS  Google Scholar 

  13. Heller H, Sakhaee K, Moe OW, Pak CY (2002) Etiological role of estrogen status on renal formation. J Urol 168:1923–1927

    Article  PubMed  CAS  Google Scholar 

  14. Rockenbauer M, Olsen J, Czeizel AE, Pedersen L, Sorensen HT, the EuroMAP Group (2001) Recall bias in a case–control study on the use of medicine during pregnancy. Epidemiology 12:461–466

    Article  PubMed  CAS  Google Scholar 

  15. Laerum E, Larsen S (1984) Thiazide prophylaxis of urolithiasis: a double blind study in general practice. Acta Med Scand 215:383–389

    Article  PubMed  CAS  Google Scholar 

  16. Ellinger B, Pak CY, Citron JT, Thomas C, Adams-Huet B, Vangessel A (1997) Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. J Urol 158:2069–2073

    Article  Google Scholar 

  17. Gettman MT, Segura JW (1995) Struvite stones: diagnosis and current treatment concepts. J Endocrinol 13:653–658

    Google Scholar 

Download references

Acknowledgment

This study was partly sponsored by a generous grant from Richter Gedeon Pharmaceuticals Ltd., Budapest, Hungary.

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Authors and Affiliations

  1. Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary

    F. Bánhidy & N. Ács

  2. Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary

    A. E. Czeizel

  3. Department of Human Genetics and Teratology, National Center for Healthcare Audit and Improvement, Budapest, Hungary

    E. H. Puhó

  4. Törökvész lejtő 32, 1026, Budapest, Hungary

    A. E. Czeizel

Authors
  1. F. Bánhidy
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  2. N. Ács
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  3. E. H. Puhó
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  4. A. E. Czeizel
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Corresponding author

Correspondence to A. E. Czeizel.

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Bánhidy, F., Ács, N., Puhó, E.H. et al. Maternal kidney stones during pregnancy and adverse birth outcomes, particularly congenital abnormalities in the offspring. Arch Gynecol Obstet 275, 481–487 (2007). https://doi.org/10.1007/s00404-006-0277-1

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  • DOI: https://doi.org/10.1007/s00404-006-0277-1

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