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Granular cell tumor of the vulva: six new cases

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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Granular cell tumors are rare neoplastic skin and soft tissue lesions: only 1–2% are malignant. Five to sixteen percent occur in the vulva. We present our experience with granular cell tumors of the vulva in six patients, all of whom had wide local excisions and were followed-up in our outpatient clinic for 3–171 months. One died of an unrelated cause. None of the others has evidence of the disease.

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References

  1. Abenoza P, Sibley RK (1987) Granular cell myoma and schwannoma: fine structural and immunohistochemical study. Ultrastruct Pathol 11:19–28

    Article  PubMed  CAS  Google Scholar 

  2. Abrikossoff A (1926) Über Myome ausgehend von der quergestreifter willkürlichen Muskulatur. Virchows Arch A Pathol Anat Histopathol 260:215–233

    Google Scholar 

  3. Althausen AM, Kowalski DP, Ludwig ME, Curry SL, Greene JF (2000) Granular cell tumors: a new clinically important histologic finding. Gynecol Oncol 77:310–313

    Article  PubMed  CAS  Google Scholar 

  4. Apisarnthanarax P (1981) Granular cell tumor. An analysis of 16 cases and review of the literature. J Am Acad Dermatol 5:171–182

    Article  PubMed  CAS  Google Scholar 

  5. Azzoparidi JG (1956) Histogenesis of granular cell myoblastoma. J Pathol Bacteriol 71:85–94

    Article  PubMed  Google Scholar 

  6. Berlin SJ (1980) A review of 2,720 lesions of the foot. J Am Pediatr Assoc 70:318–324

    CAS  Google Scholar 

  7. Cadotte M (1974) Malignant granular cell myoblastoma. Cancer 33:1417–1422

    Article  PubMed  CAS  Google Scholar 

  8. Coates JB, Hales JS (1973) Granular cell myoblastoma of the vulva. Obstet Gynecol 41:796–799

    PubMed  Google Scholar 

  9. Copas P, Dyer M, Hall DJ, Driddle AW (1981) Granular cell myoblastoma of the Uterine cervix. Diagn Gynecol Obstet 3:251–254

    PubMed  CAS  Google Scholar 

  10. Dgani R, Czernobilsky B, Borenstein R, Lancet M (1978) Granular cell myoblastoma of the vulva. Acta Obstet Gynecol Scand 57:385–387

    Article  PubMed  CAS  Google Scholar 

  11. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG (1998) Malignant granular cell tumor of soft tissue. Diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 22:779–794

    Article  PubMed  CAS  Google Scholar 

  12. Garancis JC, Komorowski RA, Kuzma JF (1970) Granular cell myoblastoma. Cancer 25:542–550

    Article  PubMed  CAS  Google Scholar 

  13. Gardner ES, Goldberg LH (2001) Granular cell tumor treated with Mohs micrographic surgery: report of a case and review of the literature. Dermatol Surg 27:772–774

    Article  PubMed  CAS  Google Scholar 

  14. Geunther L, Shum D (1993) Granular cell tumor of the vulva. Pediatr Dermatol 10:153–155

    PubMed  Google Scholar 

  15. Gifford RRM, Birch HW (1973) Granular cell myoblastoma of multicentric origin involving the vulva. Am J Obstet Gynecol 117:184–187

    PubMed  CAS  Google Scholar 

  16. Gross VL, Lynfield Y (2002) Multiple cutaneous granular cell tumors: a case report and review of the literature. Cutis 69:343–346

    PubMed  Google Scholar 

  17. Horowitz IR, Copas P, Majmurdar B (1995) Granular cell tumors of the vulva. Am J Obstet Gynecol 173:1710–1714

    Article  PubMed  CAS  Google Scholar 

  18. Jardines L, Cheung L, LiVolsi, Hendrickson S, Brooks JJ (1994) Malignant granular cell tumors: report of a case and review of the literature. Surgery 116:49–54

    PubMed  CAS  Google Scholar 

  19. Khansur T, Balducci L, Tavassoli M (1987) Granular cell tumor. Clinical spectrum of the benign and malignant entity. Cancer 60:220–222

    Article  PubMed  CAS  Google Scholar 

  20. Lack EE, Worsham GF, Callihan M et al (1980) Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol 13:301–316

    Article  PubMed  CAS  Google Scholar 

  21. Majmudar B, Castellano PZ, Wilson RW, Siegel RJ (1990) Granular cell tumors of the vulva. J Reprod Med 35:1008–1014

    PubMed  CAS  Google Scholar 

  22. Morrison JG, Gray GF, Dao AH, Adkins RB (1987) Granular cell tumors. Am Surg 53:156–160

    PubMed  CAS  Google Scholar 

  23. Murray MR (1951) Culture characteristics of three granular cell myoblastomas. Cancer 4:857–865

    Article  PubMed  CAS  Google Scholar 

  24. Ordonez NG, Mackay B (1999) Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol 23:207–222

    Article  PubMed  CAS  Google Scholar 

  25. Ortiz-Hidalgo C, de la Vega G, Moreno-Collado C (1997) Granular cell tumor (Abrikossoff tumor) of the clitoris. Int J Dermatol 36:935–937

    Article  PubMed  CAS  Google Scholar 

  26. Pearse AGE (1950) The histogenesis of granular cell myoblastoma (granular cell perineural fibroblastoma). J Pathol Bacteriol 62:351–362

    Article  PubMed  CAS  Google Scholar 

  27. Powell EB (1946) Granular cell myoblastoma. Arch Pathol 42:517–524

    CAS  Google Scholar 

  28. Pressoir R, Chung EB (1980) Granular cell tumor in black patients. J Natl Med Assoc 72:1171–1175

    PubMed  CAS  Google Scholar 

  29. Ramos PC, Kapp DS, Longacre TA, Teng NNH (2000) Malignant granular cell tumor of the vulva in a 17-year-old: case report and literature review. Int J Gynecol Cancer 10:429–434

    Article  PubMed  Google Scholar 

  30. Rifkin RH, Blocker SH, Palmer JO, Ternberg JL (1986) Multiple granular cell tumors: a familial occurrence in children. Arch Surg 121:945–947

    PubMed  CAS  Google Scholar 

  31. Schmidt O, Fleckenstein GH, Gunawan B, Fuzesi L, Emons G (2003) Recurrent and rapid metastasis formation of a granular cell tumor of the vulva. Eur J Obstet Gynecol Reprod Biol 106:219–221

    Article  PubMed  Google Scholar 

  32. Smith SB, Farley MF, Albertini JG, Elston DM (2002) Mohs micrographic surgery for granular cell tumor using S-100 immunostain. Dermatol Surg 28:1076–1078

    Article  PubMed  Google Scholar 

  33. Tsuchida T, Okada K, Itoi E, Sato T, Sato K (1997) Intramuscular malignant granular cell tumor. Skeletal Radiol 26:116–121

    Article  PubMed  CAS  Google Scholar 

  34. Weber CO (1854) Anatomische Untersuchang einer hypertropphischen Zunge nebst Bemrkungen uber die Nenbildung quergestreifter Muskelfasern. Virchows Arch A Pathol Anat Histopathol 7:115–125

    Google Scholar 

  35. Wolber RA, Talerman A, Wilkinson EJ, Clement PB (1991) Vulvar granular cell tumors with pseudocarcinomatons hyperplasia: a comparative analysis with well-differentiated squamous carcinoma. Int J Gynecol Pathol 10:59–66

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel

    Hanoch Levavi, Gad Sabah & Boris Kaplan

  2. Department of Orthopedics, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel

    Yehezkel Tytiun

  3. Institution of Pathology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel

    Diana Braslavsky

  4. Department of Surgery B, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel

    Haim Gutman

Authors
  1. Hanoch Levavi
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  2. Gad Sabah
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  3. Boris Kaplan
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  4. Yehezkel Tytiun
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  5. Diana Braslavsky
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  6. Haim Gutman
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Corresponding author

Correspondence to Hanoch Levavi.

Additional information

Rabin Medical Center is affilated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Levavi, H., Sabah, G., Kaplan, B. et al. Granular cell tumor of the vulva: six new cases. Arch Gynecol Obstet 273, 246–249 (2006). https://doi.org/10.1007/s00404-005-0054-6

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  • DOI: https://doi.org/10.1007/s00404-005-0054-6

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