Abstract
The mechanism of final cessation of the reproductive life span has not been solved yet. It is generally assumed that the most important factor is ovarian follicular reserve. In ovaries at intrauterine period, a major factor that determines the number of the primordial follicle is the mitotic ability as well as the number of primordial germ cells, which migrate to gonadal ridge. The telomere length is one factor that determines the number of mitosis of the cell. The differences between the telomere lengths of same aged healthy women reflect the difference of the telomeres of the primordial germ cells at the intrauterine period. Women with long telomeres supposedly have had their primordial germ cells at the beginning of life with long telomeres. So, these cells should have had more mitotic division and more follicle numbers in the ovaries than the short ones. The aim of this study was to analyse the relation of the reproductive life span and telomere length. The telomere lengths of 37 women volunteers aged 50 years were measured by fiber FISH technique. A positive correlation was found between reproductive life span and the telomere length.
Similar content being viewed by others
References
Brambilla DJ, McKinlay SM (1989) A prospective study of factors affecting age at menopause. J Clin Epidemiol 42:1031–1039
Bibby MC (2003) An introduction to telomeres and telomerase. Molecular Biotechnology 24(3):295–301
Cramer DW, Xu H, Harlow BL (1995) Family history as a predictor of early menopause. Fertil Steril 64:740–745
Cramer DW, Xu H, Harlow BL (1995) Does “incessant” ovulation increase risk for early menopause? Am J Obstet Gynecol 172:568–573
Dorland M, Van Kooij RJ, te Velde ER (1998). General ageing and ovarian ageing. Maturitas 12:113–118
Ginsburg J (1991) What determines the age at the menopause? The number of ovarian follicles seems the most important factor. BrMedJ 302:1288–1289
Kinugawa C, Murakomi T, Okamura K, Yajima A (2000) Telomerase activity in normal ovarias and premature ovarian failure. Tokahu J Exp Med 190:231–238
Kipling D (1995) The Telomere. Oxford University Press, New York, pp 134
Kline K, Kinney A, Levin B et al (2000) Trisomic pregnancy and early age at menopause. Am J Hum Genet 67:395–404
Mais V, Ajossa S, Guerriero S, Paoletti AM, Melis GB (1995) The role of follicle-stimulating hormone in the depletion of follicular reserve: menopause in a woman with hypogonadotropic hypoestrogenic amenorrhea: a case report. Fertil Steril 63:669–672
Mathieu N, Pirzio L, Freulet-Marriere A, Desmaza C, Sabatier L (2004) Telomeres and chromosomal instability 61:641–656
Parra FI, Windle B (1993) High resolution visual mapping of stretched DNA by fluorescent hybridization. Nat Genet 5:17–21
Pines A, Shapira I, Mijatovic V, Margalioth EJ, Frenkel Y (2002) The impact of hormonal therapy for infertility on age at menopause. Maturitas 41:283–287
Richardson SJ, Senikas V, Nelson JF (1987) Follicular depletion during the menopausal transition; evidence for accelarated loss and ultimate exhaustion. J Clin Endocrinol Metab 65:1231–1237
Richardson SJ, Nelson JF (1990) Follicular depletion during the menopausal transition. Ann N Y Acad Sci 592:13–20
Senger G, Jones TA, Fidlerova H, Sanseau P, Trowsdale J, Duff M, Sheer D (1994) Released chromatin: linearized DNA for high resolution fluorescence in situ hybridization. Hum Mol Genet 8(3):1275–1280
Snieder H, MacGregor AJ, Spector TD (1998) Genes control the cessation of a woman’s reproductive life: a twin study of hysterectomy and age at menopause. J Clin Endocrinol Metab 83:1875–1880
Torgerson DJ, Thomas RE, Campbell MK, Reid DM (1997) Alcohol consumption and age of maternal menopause are associated with menopause onset. Maturitas 26: 21–25
Torgerson DJ, Thomas RE, Reid DM (1997) Mothers and daughters menopausal ages: is there a link? Eur J Obstet Gynecol Reprod Biol 74:63–66
Van Roy N, Laureys G, Van Gele M, Opdenakker G, Miura R, van der Drift, Chan A, Versteeg R, Speleman F (1997) Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes. Eur J Cancer 33:1974–1978
Venturin M, Gervasini C, Orzan F, Bentivegna A, Corrado L, Colapietro P, Friso A, Tenconi R, Upadhyaya M, Larizza L, Riva P (2004) Evidence for non-homologous end joining and noallelic homologous recombination in atypical NF1 microdeletions. Hum Genet 115:69–80
Weier H-UG, Wang M, Mullikin JC, Zhu Y, Cheng J-F, Greulich KM, Bensimon A, Gray JW (1995) Quantitative DNA fiber mapping. Hum Mol Genet. 4:1903–1910
Whelan EA, Sandler DP, McConnaughey DR et al. (1990) Menstrual and reproductive characteristics and age at natural menopause. Am J Epidemiol 131:625–632
Wise PM, Krajnak KM, Kashon ML (1996) Menopause: the aging of multiple pacemakers. Science 273:67–70
Acknowledgements
This work was supported by Ankara University Research Foundation (Project No:2001-08-09-056). The authors are particularly grateful to Professor Işık Bökesoy and Professor Sevim Dinçer Cengiz for their support and valuable discussion.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Aydos, S.E., Elhan, A.H. & Tükün, A. Is telomere length one of the determinants of reproductive life span?. Arch Gynecol Obstet 272, 113–116 (2005). https://doi.org/10.1007/s00404-004-0690-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-004-0690-2