Abstract
Introduction
Large cell neuroendocrine carcinoma is a rare aggressive cervical neoplasm, considerably rarer than the well-recognized small cell neuroendocrine carcinoma of the cervix. Cervical large cell neuroendocrine carcinomas are distinctive cervical carcinomas that are frequently misdiagnosed and have an unfavorable outcome, similar to that of small cell carcinoma.
Case report
We report a 45-year-old woman with large cell neuroendocrine uterine cervical carcinoma.
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Albores-Saavedra J, Gersell D, Gilks CB (1997) Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med 121:34–39
Gilks CB, Young RB, Gersell DJ, Clement PB (1997) Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am J Surg Pathol 21:905–914
Grayson W, Rhemtula H, Taylor LF, Allard U, Tiltman AJ (2002) Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases. J Clin Pathol 55:108–114
Kim YB, Barbuto D, Lagasse LD, Karlan BY (1996) Successful treatment of neuroendocrine small cell carcinoma of the cervix metastatic to regional lymph nodes. Gynecol Oncol 62:411–414
Krivak TC, McBroom JW, Sundborg MJ, Crothers B, Parker MF (2001) Large cell neuroendocrine cervical carcinoma: a report of two cases and review of the literature. Gynecol Oncol 82:187–191
Lewandowski GS, Copeland LJ (1993) A potential role for intensive chemotherapy in the treatment of small cell neuroendocrine tumors of the cervix. Gynecol Oncol 48:127–131
Cui S, Lespinasse P, Cracchiolo B, Sama J, Kreitzer MS, Heller DS (2001) Large cell neuroendocrine carcinoma of the cervix associated with adenocarcinoma in situ: evidence of a common origin. Int J Gynecol Pathol 20:311–312
O'Hanlan KA, Goldberg GL, Jones JG, Runowicz CD, Ehrlich L, Rodriguez LR (1991) Adjuvant therapy for neuroendocrine small cell carcinoma of the cervix: review of the literature. Gynecol Oncol 43:167–172
Rhemtula H, Grayson W, van Iddekinge B, Tiltman A (2001) Large-cell neuroendocrine carcinoma of the uterine cervix—a clinicopathological study of five cases. S Afr Med J 91:525–528
Robboy SJ, Anderson MC, Russell P (2002) Pathology of the female reproductive tract. Malignant tumors of the cervix. Churchill Livingstone, New York, pp 227–229
Savorgaonkar PR, Hale RJ, Muttan J, Monning V, Buckley CH (1996) Neuroendocrine differentiation in cervical carcinoma. J Clin Pathol 49:139–141
Sheets EE, Berman ML, Hrountas CE, Liao SY, DiSaia PJ (1988) Surgically treated, early-stage neuroendocrine small-cell cervical carcinoma. Obstet Gynecol 71:10–14
Tsou MH, Tan TD, Cheng SH, Chiou YK (1998) Small cell carcinoma of the uterine cervix with large cell neuroendocrine carcinoma component. Gynecol Oncol 68:69–72
Turner WA, Galloup DG, Talledo OE, Otke LB, Guthrie TH (1986) Neuroendocrine carcinoma of the uterine cervix complicated by pregnancy: case report and review of the literature. Obstet Gynecol 67:80–83
Yun K, Cho NP, Glassford GN (1999) Large cell neuroendocrine carcinoma of the uterine cervix: a case report of a case with coexisting cervical intraepithelial neoplasia and human papillomavirus 16. Pathology 31:158–161
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Dikmen, Y., Kazandi, M., Zekioglu, O. et al. Large cell neuroendocrine carcinoma of the uterine cervix: a report of a case and review of the literature. Arch Gynecol Obstet 270, 185–188 (2004). https://doi.org/10.1007/s00404-003-0482-0
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DOI: https://doi.org/10.1007/s00404-003-0482-0