Skip to main content
Log in

Large cell neuroendocrine carcinoma of the uterine cervix: a report of a case and review of the literature

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Large cell neuroendocrine carcinoma is a rare aggressive cervical neoplasm, considerably rarer than the well-recognized small cell neuroendocrine carcinoma of the cervix. Cervical large cell neuroendocrine carcinomas are distinctive cervical carcinomas that are frequently misdiagnosed and have an unfavorable outcome, similar to that of small cell carcinoma.

Case report

We report a 45-year-old woman with large cell neuroendocrine uterine cervical carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

References

  1. Albores-Saavedra J, Gersell D, Gilks CB (1997) Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med 121:34–39

    CAS  PubMed  Google Scholar 

  2. Gilks CB, Young RB, Gersell DJ, Clement PB (1997) Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am J Surg Pathol 21:905–914

    Article  CAS  PubMed  Google Scholar 

  3. Grayson W, Rhemtula H, Taylor LF, Allard U, Tiltman AJ (2002) Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases. J Clin Pathol 55:108–114

    CAS  PubMed  Google Scholar 

  4. Kim YB, Barbuto D, Lagasse LD, Karlan BY (1996) Successful treatment of neuroendocrine small cell carcinoma of the cervix metastatic to regional lymph nodes. Gynecol Oncol 62:411–414

    Article  CAS  PubMed  Google Scholar 

  5. Krivak TC, McBroom JW, Sundborg MJ, Crothers B, Parker MF (2001) Large cell neuroendocrine cervical carcinoma: a report of two cases and review of the literature. Gynecol Oncol 82:187–191

    Article  CAS  PubMed  Google Scholar 

  6. Lewandowski GS, Copeland LJ (1993) A potential role for intensive chemotherapy in the treatment of small cell neuroendocrine tumors of the cervix. Gynecol Oncol 48:127–131

    Article  CAS  PubMed  Google Scholar 

  7. Cui S, Lespinasse P, Cracchiolo B, Sama J, Kreitzer MS, Heller DS (2001) Large cell neuroendocrine carcinoma of the cervix associated with adenocarcinoma in situ: evidence of a common origin. Int J Gynecol Pathol 20:311–312

    PubMed  Google Scholar 

  8. O'Hanlan KA, Goldberg GL, Jones JG, Runowicz CD, Ehrlich L, Rodriguez LR (1991) Adjuvant therapy for neuroendocrine small cell carcinoma of the cervix: review of the literature. Gynecol Oncol 43:167–172

    CAS  PubMed  Google Scholar 

  9. Rhemtula H, Grayson W, van Iddekinge B, Tiltman A (2001) Large-cell neuroendocrine carcinoma of the uterine cervix—a clinicopathological study of five cases. S Afr Med J 91:525–528

    CAS  PubMed  Google Scholar 

  10. Robboy SJ, Anderson MC, Russell P (2002) Pathology of the female reproductive tract. Malignant tumors of the cervix. Churchill Livingstone, New York, pp 227–229

  11. Savorgaonkar PR, Hale RJ, Muttan J, Monning V, Buckley CH (1996) Neuroendocrine differentiation in cervical carcinoma. J Clin Pathol 49:139–141

    PubMed  Google Scholar 

  12. Sheets EE, Berman ML, Hrountas CE, Liao SY, DiSaia PJ (1988) Surgically treated, early-stage neuroendocrine small-cell cervical carcinoma. Obstet Gynecol 71:10–14

    CAS  PubMed  Google Scholar 

  13. Tsou MH, Tan TD, Cheng SH, Chiou YK (1998) Small cell carcinoma of the uterine cervix with large cell neuroendocrine carcinoma component. Gynecol Oncol 68:69–72

    Article  CAS  PubMed  Google Scholar 

  14. Turner WA, Galloup DG, Talledo OE, Otke LB, Guthrie TH (1986) Neuroendocrine carcinoma of the uterine cervix complicated by pregnancy: case report and review of the literature. Obstet Gynecol 67:80–83

    Google Scholar 

  15. Yun K, Cho NP, Glassford GN (1999) Large cell neuroendocrine carcinoma of the uterine cervix: a case report of a case with coexisting cervical intraepithelial neoplasia and human papillomavirus 16. Pathology 31:158–161

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mert Kazandi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dikmen, Y., Kazandi, M., Zekioglu, O. et al. Large cell neuroendocrine carcinoma of the uterine cervix: a report of a case and review of the literature. Arch Gynecol Obstet 270, 185–188 (2004). https://doi.org/10.1007/s00404-003-0482-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-003-0482-0

Keywords

Navigation