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Treatment of obstetric hemorrhage with recombinant activated factor VII (rFVIIa)

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Abstract.

Recombinant activated factor VII (rFVIIa, NovoSeven®) was used in three patients with massive obstetric hemorrhage due to placenta previa accreta, rupture of the uterus and pre-eclampsia with HELLP. Administration of the drug markedly decreased the bleeding and enabled control of the hemorrhage. rFVIIa seems to be an adjunctive hemostatic measure for the treatment of severe obstetric hemorrhage.

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References

  1. Hedner U, Ingerslev J (1998) Clinical use of recombinant FVIIa. Trans Sci 19:163–176

    Google Scholar 

  2. Martinowitz U, Holcomb JB, Pusateri AE, Macaitis JM, Hedner U, Hess JR (2001) Intravenous rFVIIa administered for hemorrhage control in hypothermic coagulopathic swine with grade V liver injuries. J Trauma 50:721–729

    Google Scholar 

  3. Martinowitz U, Kenet G, Segal E, Luboshitz J, Lubetsky A, Ingersiev J, Lynn M (2001) Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma 51:431–439

    Google Scholar 

  4. Martinowitz U, Luboshitz J, Lubetsky A, Kenet G (2001) New approach for the management of coagulation at the site of injury by recombinant activated factor VII (rVIIa). Blood 98:827–828

    Google Scholar 

  5. Moscardo F, Perez F, De la Rubia J, Balerdi B, Loernzo JI, Senent ML, Aznar I, Carceller S, Sanz MA (2001) Successful treatment of severe intra-abdominal bleeding associated with disseminated intravascular coagulation using recombinant activated factor VII. Br J Haematol 114:174–176

    Google Scholar 

  6. Shapiro AD, Gilchrist GS, Hoots WK, Cooper HA, Gastineau DA (1998) Prospective, randomized trial of two doses of rFVIIa (Novoseven) in hemophilia patients with inhibitors undergoing surgery. Thromb Haemost 80:773–778

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Ben-Gurion University of The Negev, Barzilai Medical Center, Ashkelon, Israel 78306, Israel

    S. Segal

  2. Respiratory Intensive Care Unit, Barzilai Medical Center, Ashkelon, Israel, Israel

    I. Y. Shemesh

  3. Institute of Hematology, Barzilai Medical Center, Ashkelon, Israel, Israel

    R. Blumenthal

  4. Department of General and Vascular Surgery, Barzilai Medical Center, Ashkelon, Israel, Israel

    B. Yoffe

  5. Department of Obstetrics and Gynecology, Hadassah University Hospital, The Hebrew University, Jerusalem, Israel, Israel

    N. Laufer & Y. Ezra

  6. Department of General and Vascular Surgery, Ben-Gurion University of The Negev, Soroka Medical Center, Beer-Sheva, Israel, Israel

    I. Levy

  7. Department of Obstetrics and Gynecology, Ben-Gurion University of The Negev, Soroka Medical Center, Beer-Sheva, Israel, Israel

    M. Mazor

  8. Institute of Hematology, The National Hemophilia Center, The Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, Israel

    U. Martinowitz

Authors
  1. S. Segal
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  2. I. Y. Shemesh
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  3. R. Blumenthal
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  4. B. Yoffe
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  5. N. Laufer
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  6. Y. Ezra
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  7. I. Levy
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  8. M. Mazor
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  9. U. Martinowitz
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Corresponding author

Correspondence to S. Segal.

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Segal, S., Shemesh, I.Y., Blumenthal, R. et al. Treatment of obstetric hemorrhage with recombinant activated factor VII (rFVIIa). Arch Gynecol Obstet 268, 266–267 (2003). https://doi.org/10.1007/s00404-002-0409-1

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  • DOI: https://doi.org/10.1007/s00404-002-0409-1

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