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Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders

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Abstract

The grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications. This paper discusses the favorable effects of RES, GSE and their nanoformulations for dermatological approaches, with specific emphasis on clinical interventions. In this manner, electronic databases including PubMed, Science Direct and Google Scholar were searched. Data were collected from 1980 up to February 2019. The search terms included “Vitis vinifera”, “grape”, “resveratrol”, “skin”, “dermatology”, and “nanoformulation”. To increase the skin permeability of GSE and RES, several innovative nanoformulation such as liposomes, niosomes, solid–lipid nanoparticles, nanostructured lipid carriers, and lipid-core nanocapsule has been evaluated. According to our extensive searches, both RES and GSE have beneficial impacts on skin disorders such as chloasma, acne vulgaris, skin aging, as well as wound and facial redness. More clinical studies with nanoformulation approaches are recommended to achieve conclusive outcomes regarding the efficacy of RES and GSE in the management of skin diseases.

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Abbreviations

CVI:

Chronic venous insufficiency

DPPH:

2,2-Diphenyl-1-picrylhydrazyl

EGCG:

Epigallocatechin gallate

EIM:

Ethanol injection-modified method

GS–MS:

Gas chromatography–mass spectrometry

GSE:

Grape seed extract

HPLC:

High-performance liquid chromatography

ICD:

Irritant contact dermatitis

LNC:

Lipid-core nanocapsule

MPO:

Myeloperoxidase

NLC:

Nanostructured lipid carriers

PAMAM:

Polyamidoamine

PG:

Propylene glycol

PUVA:

Psoralen with ultraviolet-A

PSR:

Psoralen

RES:

Resveratrol

QUE:

Quercetin

ROS:

Reactive oxygen species

SDC:

Deoxycholate

SNL:

Solid–lipid nanoparticles

TPA:

12-O-Tetradecanoylphorbol 13-acetate

UDL:

Ultra-deformable liposomes

UV:

Ultraviolet

VE:

Vitamin E

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Authors and Affiliations

  1. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Samaneh Soleymani

  2. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Samaneh Soleymani

  3. Student’s Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Amin Iranpanah

  4. Department of Dermatology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Fariba Najafi

  5. Centre for Biodiversity Conservation and Management, G. B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi-Katarmal, Almora, Uttarakhand, 263643, India

    Tarun Belwal

  6. DBS School of Agriculture and Allied Sciences, Dehradun, Uttarakhand, India

    Sudipta Ramola

  7. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Zahra Abbasabadi & Mohammad Hosein Farzaei

  8. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran

    Saeideh Momtaz

  9. Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran

    Saeideh Momtaz

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  1. Samaneh Soleymani
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Soleymani, S., Iranpanah, A., Najafi, F. et al. Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders. Arch Dermatol Res 311, 577–588 (2019). https://doi.org/10.1007/s00403-019-01930-z

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