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Autoantibodies to desmogleins 1 and 3 in patients with lichen planus

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An Erratum to this article was published on 08 August 2017

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Abstract

There is controversy about the role of autoantibodies against desmoglein 1 and 3 (Dsg1 and 3) in the pathogenesis of lichen planus (LP); the authors planned this study to determine the presence of circulating levels of these antibodies in patients with different types of oral LP and to compare that with cutaneous LP and healthy controls. The enzyme-linked immunosorbent assay test was performed on serum samples of 24 cases of erosive oral LP, 29 cases of reticular oral LP, 30 cases of cutaneous LP and 30 healthy controls. The severity of oral LP was evaluated by Reticulation, Erosion and Ulceration scoring system. There were no significant differences in the concentrations of autoantibodies to Dsg1 between the four groups. Autoantibodies to Dsg3 were increased in erosive oral LP compared with healthy controls (p value = 0.005) but no increase was observed between other groups. We did not detect a correlation between the severity of the disease and the levels of anti-Dsg1 and 3 in patients with erosive and reticular types of oral LP. In conclusion, regardless of the increased level of anti-Dsg3 antibody in erosive oral LP, serum concentrations of antibodies were under cut-off values. Moreover, the pathogenic role of anti-Dsg3 antibodies in erosive oral LP is uncertain.

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  • 08 August 2017

    An erratum to this article has been published.

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Acknowledgements

This study was supported by Tehran University of Medical Sciences and Health Services. We thank our colleagues in Razi Hospital, especially Dr. Maryam Daneshpazhooh for comments that improved the manuscript.

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Authors and Affiliations

  1. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Lajevardi Vahide, Halaji Zahra & Ghaedi Forugh

  2. Azad University of Medical Sciences, Tehran, Iran

    Saljoughi Nazi

Authors
  1. Lajevardi Vahide
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  2. Halaji Zahra
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  3. Ghaedi Forugh
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  4. Saljoughi Nazi
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Corresponding author

Correspondence to Ghaedi Forugh.

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The authors declare that they have no conflict of interest.

Funding

This study was funded by Tehran University of Medical Sciences.

Ethical statement

The study was approved by the Ethics Committee of Tehran University of Medical Sciences.

Informed consent

Informed consent was obtained from each subject.

Additional information

An erratum to this article is available at https://doi.org/10.1007/s00403-017-1766-8.

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Vahide, L., Zahra, H., Forugh, G. et al. Autoantibodies to desmogleins 1 and 3 in patients with lichen planus. Arch Dermatol Res 309, 579–583 (2017). https://doi.org/10.1007/s00403-017-1756-x

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  • DOI: https://doi.org/10.1007/s00403-017-1756-x

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