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Increased miRNA-146a and miRNA-155 expressions in oral lichen planus

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Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease T helper 1 lymphocytes (Th1)-mediated. Interferon-gamma (IFN-γ) plays a central role in local immune response in this disease. MicroRNAs (miRNAs) are endogenously expressed non-coding RNAs that have important biological and pathological functions due to their potential mechanism regulating gene expression. Recently, some studies have demonstrated that miRNA-146a and miRNA-155 participate in immune response regulation, and are important in several chronic inflammatory and autoimmune diseases. The purpose of the present study was to investigate the expression of the miRNA-146a and miRNA-155 in 31 OLP lesions compared to normal oral mucosa and blood samples. Quantitative real-time polymerase chain reaction was used to analyze miRNA expressions. Our results showed increased expression of miRNA-146a and miRNA-155 in OLP lesions. In conclusion, these data highlight the possibility of miRNA-146a and miRNA-155 involvement in the regulation of the immune response in OLP.

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Acknowledgments

This study was supported in part by grants from Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and from Conselho Nacional e Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Dr ALS Guimarães and Professor RS Gomez are research fellows of CNPq.

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Authors and Affiliations

  1. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Telma Cristina Arão & Ricardo Santiago Gomez

  2. School of Dentistry, Universidade Estadual de Montes Claros, Belo Horizonte, MG, Brazil

    André Luiz Sena Guimarães & Alfredo Maurício Batista de Paula

  3. Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Carolina Cavaliéri Gomes

  4. Laboratório de Biologia Molecular, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, CEP 31.270-901, Belo Horizonte, MG, Brazil

    Ricardo Santiago Gomez

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  1. Telma Cristina Arão
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  2. André Luiz Sena Guimarães
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  3. Alfredo Maurício Batista de Paula
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  4. Carolina Cavaliéri Gomes
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Correspondence to Ricardo Santiago Gomez.

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Arão, T.C., Guimarães, A.L.S., de Paula, A.M.B. et al. Increased miRNA-146a and miRNA-155 expressions in oral lichen planus. Arch Dermatol Res 304, 371–375 (2012). https://doi.org/10.1007/s00403-011-1197-x

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  • DOI: https://doi.org/10.1007/s00403-011-1197-x

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