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Apolipoprotein E gene polymorphism in psoriasis

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Abstract

Polymorphism in the apolipoprotein E gene has been associated with several neurological, cardiological and ophthalmological diseases. Apolipoprotein E is involved in psoriasis by modifying mitogen-activated T lymphocyte proliferation and by assuring protection against some infections. We evaluated the apolipoprotein E gene polymorphism in patients suffering from psoriasis (compared to matched controls) in Thrace, Northern Greece. One hundred and forty patients suffering from psoriasis vulgaris and 155 matched controls were included in this study and genotyped by semi-nested polymerase chain reaction RFLPs; the results were evaluated by conditional logistic regression. In psoriasis vulgaris patients, the e2 allele showed higher frequency (6.1%, P = 0.021) versus matched controls (2.3%). The above data were ascertained particularly enforced in psoriasis vulgaris male patients (P = 0.031) as well as in late onset psoriasis vulgaris (P = 0.029). Implication of apolipoprotein E in the pathogenesis of psoriasis has been indicated. Allele e2 is more frequent in psoriatic patients and its presence is more evident in late onset psoriasis vulgaris.

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Authors and Affiliations

  1. Faculty of Medicine, University Clinic of Dermatology, Democritus University of Thrace, 68100, Alexandroupolis, Greece

    Anthony Karpouzis

  2. Faculty of Medicine, University Laboratory of Medical Biology, Democritus University of Thrace, 681 00, Alexandroupolis, Greece

    Rozina Caridha, Charalambos Michailidis & Stavroula Vouliana Veletza

  3. Faculty of Medicine, Department of Medical Statistics, Democritus University of Thrace, 68100, Alexandroupolis, Greece

    Gregory Tripsianis

  4. Department of Blood Donation, University Hospital of Alexandroupolis, 68100, Alexandroupolis, Greece

    George Martinis

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  1. Anthony Karpouzis
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Correspondence to Stavroula Vouliana Veletza.

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Karpouzis, A., Caridha, R., Tripsianis, G. et al. Apolipoprotein E gene polymorphism in psoriasis. Arch Dermatol Res 301, 405–410 (2009). https://doi.org/10.1007/s00403-009-0968-0

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