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Association between tumor necrosis factor-alpha gene promoter polymorphism at position -308 and acne in Turkish patients

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Abstract

Acne is a multifactorial, chronic inflammatory disease of pilosebaceous unit in which cytokines have been implicated in the pathogenesis. Although it is thought to be an inherited disease, there are limited data supporting the relevant genetic elements. Tumor necrosis factor-alpha (TNF-alpha) is one of the proinflammatory cytokines involved in the acne pathogenesis. Several single-nucleotide polymorphisms (SNPs) have been identified in the human TNF-alpha gene promoter. The polymorphism at position -308, which involves substituting guanine (G) for adenine (A) (TNFA-308 G/A) has been linked to increased susceptibility to several chronic inflammatory diseases. The aim of this study was to determine the TNFA-308 G/A polymorphism in acne and to examine whether there is a relationship between this polymorphism and disease susceptibility. Exactly, 113 patients with acne and 114 healthy control subjects were included in the study. Polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) assay was used for analysis of the TNFA-308 G/A polymorphism. We found that the frequency of the TNFA-308 GA genotype was statistically significantly increased in patients compared with healthy controls (P < 0.001). There was no association between TNFA genotypes and severity of acne (P > 0.05). There was also no significant difference between male and female patients. Our results suggest that TNFA-308 G/A polymorphism may contribute to a predisposition to acne in Turkish population.

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Authors and Affiliations

  1. Department of Dermatology, School of Medicine, Mersin University, Mersin, 33079, Turkey

    Kıymet Baz, Ayça Cordan Yazıcı, Ulaş Güvenç & Güliz Ikizoğlu

  2. Department of Genetics, School of Medicine, Mersin University, 33079, Mersin, Turkey

    M. Emin Erdal & Fatma Söylemez

  3. Department of Biostatistics, School of Medicine, Mersin University, 33079, Mersin, Turkey

    Bahar Taşdelen

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  1. Kıymet Baz
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Baz, K., Emin Erdal, M., Yazıcı, A.C. et al. Association between tumor necrosis factor-alpha gene promoter polymorphism at position -308 and acne in Turkish patients. Arch Dermatol Res 300, 371–376 (2008). https://doi.org/10.1007/s00403-008-0871-0

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  • DOI: https://doi.org/10.1007/s00403-008-0871-0

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