Skip to main content

Advertisement

SpringerLink
Log in

Histamine helps development of eczematous lesions in experimental contact dermatitis in mice

  • Original Paper
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mice in which contact dermatitis was developed by repeated application of diphenylcyclopropenone. Development of eczematous lesions in contact dermatitis was suppressed in histamine-deficient mice compared to wild-type mice. H1 agonist ((6-12-(4-imidazol)ethylamino)-N-(4-trifluoro- methylphenyl)hepatanecarboxamide) promoted development of eczematous lesions in histamine-deficient mice. H1 receptor antagonist (loratadine) suppressed development of eczematous lesions in wild-type mice, whereas H2 agonist (dimaprit) and receptor antagonist (cimetidine) were ineffective. These results suggest that histamine facilitates the development of eczematous lesions in a murine model of contact dermatitis via H1 receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Arrang JM, Garbarg M, Schwartz JC (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302:832–837

    Article  PubMed  CAS  Google Scholar 

  2. Arrang JM, Garbarg M, Schwartz JC (1987) Autoinhibition of histamine synthesis mediated by presynaptic H3-receptor. Neuroscience 23:149–157

    Article  PubMed  CAS  Google Scholar 

  3. Baroody FM, Naclerio RM (2000) Antiallergic effects of H1-receptor antagonists. Allergy 55(Suppl):17–27

    Article  PubMed  Google Scholar 

  4. Cameron GS, Pence BC (1992) Effects of multiple applications of tumor promoters and ultraviolet radiation on epidermal proliferation and antioxidant status. J Invest Dermatol 99:189–192

    Article  PubMed  CAS  Google Scholar 

  5. Falus A, Meretey K (1988) Effect of histamine on the gene expression and secretion of complement components C2, factor B and C3 in murine macrophages—an opposite signal processing via H1 and H2 receptors. Mol Immunol 25:1093–1097

    Article  PubMed  CAS  Google Scholar 

  6. Fink K, Schlicker E, Neise A, Gothert M (1990) Involvement of presynaptic H3 receptors in the inhibitory effect of histamine on serotonin release in the rat brain cortex. Naunyu-Schmied Arch Pharmacol 342:513–519

    CAS  Google Scholar 

  7. Fitzsimons C, Engel N, Policastro L, Duran H, Molinari B, Rivera E (2002) Regulation of phospholipase C activation by the number of H(2) receptors during Ca(2+)-induced differentiation of mouse keratinocytes. Biochem Pharmacol 63:1785–1796

    Article  PubMed  CAS  Google Scholar 

  8. Gantner F, Sakai K, Tusche MW, Cruikshank WW, Center DM, Bacon KB (2002)Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8 (+) T cells. J Pharmacol Exp Ther 303:300–307

    Article  PubMed  CAS  Google Scholar 

  9. Grossman RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB (1989) Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 86:6367–6371

    Article  PubMed  CAS  Google Scholar 

  10. Hagermark O, Strandberg K, Gronneberg R (1979) Effects of histamine receptor antagonists on histamine-induced responses in human skin. Acta Derm Venereol 59:297–300

    PubMed  CAS  Google Scholar 

  11. Heyer G, Dotzer M, Diepgen TL, Handwerker HO (1997) Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis. Pain 73:239–243

    Article  PubMed  CAS  Google Scholar 

  12. Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol Rev 49:253–278

    PubMed  CAS  Google Scholar 

  13. Hirano T, Akira S, Taga T, Kishimoto T (1990) Biological and clinical aspects of interleukin 6. Immunol Today 11:443–449

    Article  PubMed  CAS  Google Scholar 

  14. Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP (2003) Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. J Pharmacol Exp Ther 305:1212–1221

    Article  PubMed  CAS  Google Scholar 

  15. Hossen MA, Sugimoto Y, Kayasuga R, Kamei C (2003) Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice. Br J Dermatol 149:17–22

    Article  PubMed  CAS  Google Scholar 

  16. Ichinose M, Barnes PJ (1989) Histamine H3-receptors modulate nonadrenergic noncholinergic neural bronchoconstriction in guinea-pig in vivo. Eur J Pharmacol 174:49–55

    Article  PubMed  CAS  Google Scholar 

  17. Kaser A, Dunzendorfer S, Offner FA, Ryan T, Schwabeggar A, Cruikshank WW, Wiedermann CJ, Tilg H (1999) A role for IL-16 in the cross-talk between dendritic cells and T cells. J Immunol 163:3232–3238

    PubMed  CAS  Google Scholar 

  18. Kitagaki H, Fujisawa S, Watanabe K, Hayakawa K, Shiohara T (1995) Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice. J Invest Dermatol 105:749–755

    Article  PubMed  CAS  Google Scholar 

  19. Kitagaki H, Ono N, Hayakawa K, Kitazawa T, Watanabe K, Shiohara T (1997) Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile. J Immunol 159:2484–2491

    PubMed  CAS  Google Scholar 

  20. Kohda F, Koga T,Uchi H, Urabe K, Furue M (2002) Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-γ and IL-4 in human keratinocytes. J Dermatol Sci 28:34–41

    Article  PubMed  CAS  Google Scholar 

  21. Koss MC, Hey JA (1993) Prejunctional inhibition of sympathetically evoked pupillary dilation in cats by activation of histamine H3 receptor. Naunyu-Schmied Arch Pharmacol 348:141–145

    Article  CAS  Google Scholar 

  22. Krawiec DR, Gaafar SM (1975) A comparative study of allergic and primary irritant contact dermatitis with dinitrochlorobenzene (DNCB) in dogs. J Invest Dermatol 65:248–251

    Article  PubMed  CAS  Google Scholar 

  23. Kupper TS, Min K, Sehgal PB, Mizutani H, Birchall N, Ray A, May L (1989) Product of IL-6 by keratinocytes: implications for epidermal inflammation and immunity. Ann N Y Acad Sci 557:454–464

    Article  PubMed  CAS  Google Scholar 

  24. Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, Fung-Leung WP (2004) Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol 142:161–171

    Article  PubMed  CAS  Google Scholar 

  25. MacGlashan D (2003) Histamine: a mediator of inflammation. J Allergy Clin Immunol 112(Suppl):S13–S19

    Article  Google Scholar 

  26. Nakamura T, Itadani H, Hidaka Y, Ohta M, Tanaka K (2000) Molecular cloning and characterization of a new human histamine receptor, HH4R. Biochem Biophys Res Commun 279:615–620

    Article  PubMed  CAS  Google Scholar 

  27. Natsuaki M, Yano N, Yamaya K, Kitano Y (2000) Immediate contact hypersensitivity induced by repeated hapten challenge in mice. Contact Dermat 43:267–272

    Article  CAS  Google Scholar 

  28. Nikaein A, Phillips C, Gilbert SC, Savino D, Silverman A, Stone MJ, Menter A (1991) Characterization of skin-infiltrating lymphocytes in patients with psoriasis. J Invest Dermatol 96:3–9

    Article  PubMed  CAS  Google Scholar 

  29. Noso N, Hide M, Nakamura K, Yamamoto S (1990) Histamine H1-receptor of vascular endothelial cells cultured from guinea pig skin. Arch Dermatol Res 282:115–119

    Article  PubMed  CAS  Google Scholar 

  30. Ohkubo T, Shibata M, Inoue M, Kaya H, Takahashi H (1994) Autoregulation of histamine release via the histamine H3 receptor on mast cells in the rat skin. Arch Int Pharmacodyn Ther 328:307–314

    PubMed  CAS  Google Scholar 

  31. Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe-Kobayashi Y, Pejler G, Tchougounova E, Hellman L, Gertsenstein M, Hirasawa N, Sakurai E, Buzas E, Kovacs P, Csaba G, Kittel A, Okada M, Hara M, Mar L, Numayama-Tsuruta K, Ishigaki-Suzuki S, Ohuchi K, Ichikawa A, Falus A, Watanabe T, Nagy A (2001) Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett 502:53–56

    Article  PubMed  CAS  Google Scholar 

  32. Ohtsu H, Kuramasu A, Tanaka S, Terui T, Hirasawa N, Hara M, Makabe-Kobayashi Y, Yamada N, Yanai K, Sakurai E, Okada M, Ohuchi K, Ichikawa A, Nagy A, Watanabe T (2002) Plasma extravasation induced by dietary supplemented histamine in histamine-free mice. Eur J Immunol 32:1698–1708

    Article  PubMed  CAS  Google Scholar 

  33. Oishi R, Adachi N, Saeki K (1993) N alpha-methylhistamine inhibits intestinal transit in mice by central histamine receptor activation. Eur J Pharmacol 237:155–159

    Article  PubMed  CAS  Google Scholar 

  34. Schlicker E, Fink K, Hinterthaner M, Gothert M (1989) Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors. Naunyu-Schmied Arch Pharmacol 340:633–638

    Article  CAS  Google Scholar 

  35. Seike M, Ikeda M, Kodama H, Terui T, Ohtsu H (2005) Inhibition of scratching behavior caused by contact dermatitis in histidine-decarboxylase gene knockout mice. Exp Dermatol 14(3):169–175

    Article  PubMed  CAS  Google Scholar 

  36. Sercombe R, Verrecchia C, Philipson V, Oudart N, Dimitriadou V, Bouchaud C, Seylaz J (1986) Histamine-induced constriction and dilatation of rabbit middle cerebral arteries in vitro: role of the endothelium. Blood Vessels 23:137–153

    PubMed  CAS  Google Scholar 

  37. Shinoda S, Kameyoshi Y, Hide M, Morita E, Yamamoto S (1998) Histamine enhances UVB-induced IL-6 production by human keratinocytes. Arch Dermatol Res 290:429–434

    Article  PubMed  CAS  Google Scholar 

  38. Takahashi K, Tanaka S, Furuta K, Ichikawa A (2002) Hiatamine H(2) receptor-mediated modulation of local cytokine expression in a mouse experimental tumor model. Biochem Biophys Res Commun 297:1205–1210

    Article  PubMed  CAS  Google Scholar 

  39. Uchi H, Terao H, Koga T, Furue M (2000) Cytokines and chemokines in the epidermis. J Dermatol Sci 24(Suppl1):S29–S38

    Article  PubMed  CAS  Google Scholar 

  40. van der Steen PHM, van Baar HMJ, Perret CM, Happle R (1991) Treatment of alopecia areata with diphenylcyclopropenone. J Am Acad Dermatol 24:253–257

    Article  PubMed  Google Scholar 

  41. Yoshida M, Takahashi Y, Inoue S (2000) Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes. J Invest Dermatol 114:334–342

    Article  PubMed  CAS  Google Scholar 

  42. Yoshimoto T, Wang CR, Yoneto T, Matsuzawa A, Cruikshank WW, Nariuchi H (2000) Role of IL-16 in delayed-type hypersensitivity reaction. Blood 95:2869–2874

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We wish to thank Shionogi & Co. (Tokyo, Japan) for providing loratadine and Sumitomo Pharmaceutical Co. (Tokyo, Japan) for providing cimetidine.

Author information

Authors and Affiliations

  1. Department of Dermatology, Kochi Medical School, Nankoku, Kochi, 783-8505, Japan

    Masahiro Seike, Tomoya Takata, Mitsunori Ikeda & Hajime Kodama

  2. Department of Dermatology, Nihon University School of Medicine, Itabashi-ku, Tokyo, 173-8610, Japan

    Tadashi Terui

  3. Applied Quantum Medical Engineering, Tohoku University School of Engineering, Aoba-ku, Sendai, Miyagi, 980-8574, Japan

    Hiroshi Ohtsu

Authors
  1. Masahiro Seike
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tomoya Takata
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mitsunori Ikeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hajime Kodama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tadashi Terui
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroshi Ohtsu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masahiro Seike.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seike, M., Takata, T., Ikeda, M. et al. Histamine helps development of eczematous lesions in experimental contact dermatitis in mice. Arch Dermatol Res 297, 68–74 (2005). https://doi.org/10.1007/s00403-005-0569-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-005-0569-5

Keywords

Search

Navigation