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Effects of human neutrophil peptide-1 on the expression of interstitial collagenase and type I collagen in human dermal fibroblasts

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Abstract

Human neutrophil peptide-1 (HNP-1), a defensin with antimicrobial properties, is also thought to promote wound healing. To elucidate the mechanism by which wound healing is facilitated by this factor, we investigated the effect of HNP-1 on the expression of interstitial collagenase (matrix metalloproteinase 1, MMP-1), collagen types I and III, and tissue inhibitor of metalloproteinase 1 (TIMP-1) by cultured fibroblasts by means of RT-PCR and ELISA. Our results showed that synthetic HNP-1 increased the expression of proα1(I) collagen mRNA and protein. In contrast, the expression of MMP-1 was decreased at both the mRNA and protein levels. Our observations suggest that HNP-1 may promote wound repair by enhancing extracellular matrix deposition and by controlling its degradation.

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Authors and Affiliations

  1. Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata-cho, 2-5-1, Okayama 700-8558, Japan, Japan

    Takashi Oono, Yoshinori Shirafuji, Wook-Kang Huh, Hisanori Akiyama & Keiji Iwatsuki

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  1. Takashi Oono
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  2. Yoshinori Shirafuji
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  3. Wook-Kang Huh
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  4. Hisanori Akiyama
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  5. Keiji Iwatsuki
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Oono, T., Shirafuji, Y., Huh, WK. et al. Effects of human neutrophil peptide-1 on the expression of interstitial collagenase and type I collagen in human dermal fibroblasts. Arch Dermatol Res 294, 185–189 (2002). https://doi.org/10.1007/s00403-002-0310-6

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  • DOI: https://doi.org/10.1007/s00403-002-0310-6

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