Abstract
Introduction
Although a large number of previous studies have investigated the outcome in patients following tibial shaft fractures, the literature provides limited information on prospectively reported patients with mid- to long-term follow-up. The present study aimed to investigate prospectively the 5-year development in patient-reported quality of life after intramedullary nailing of a tibial shaft fracture.
Material and methods
The design was a prospective, 5-year follow-up cohort study. Quality of life (QOL) was measured with the questionnaire Eq5d-5L and compared to the 1-year outcome reported by the same patients. Secondary outcome measurements were the Knee Injury and Osteoarthritis Outcome Score (KOOS), recordings of pain, gait and muscle strength.
Results
Twenty-nine patients were eligible for participation. Mean patient age at the time of the 5-year follow-up was 46.3 years. The 5-year postoperative mean Eq5d-5L index was 0.864 (95% CI 0.809–0.918). The mean Eq5d-5L VAS was 88.4 (95% CI 83.4–93.5). Compared with the same patients’ Eq5d-5L index scores at the 1-year follow-up (0.784), a significant increase was observed (P = 0.014). A comparison to the Danish Eq.5D reference population showed no statistically significant difference.
Conclusions
Patient-reported quality of life among patients treated with intramedullary nailing following a tibial shaft fracture increased significantly between the 1-year and 5-year follow-up. In contrast to the 1-year patient-reported quality of life, results are comparable to those of a reference population at the 5-year follow-up. In a clinical setting, these results highlight that patients may expect a prolonged period to recover. However, of most importance is that patients can expect a satisfactory outcome years after fracture and treatment.
Similar content being viewed by others
References
Court-Brown CM, Caesar B (2006) Epidemiology of adult fractures: a review. Injury 37:691–697
Larsen P, Elsoe R, Hansen SHSH et al (2015) Incidence and epidemiology of tibial shaft fractures. Injury 46:746–750. https://doi.org/10.1016/j.injury.2014.12.027
Babis GC, Benetos IS, Karachalios T, Soucacos PN (2007) Eight years’ clinical experience with the Orthofix tibial nailing system in the treatment of tibial shaft fractures. Injury 38:227–234. https://doi.org/10.1016/j.injury.2006.07.030
Court-Brown CM (2004) Reamed intramedullary tibial nailing: an overview and analysis of 1106 cases. J Orthop Trauma 18:96–101
Lefaivre KA, Guy P, Chan H, Blachut PA (2008) Long-term follow-up of tibial shaft fractures treated with intramedullary nailing. J Orthop Trauma 22:525–529. https://doi.org/10.1097/BOT.0b013e318180e646
Connelly CL, Bucknall V, Jenkins PJ et al (2014) Outcome at 12 to 22 years of 1502 tibial shaft fractures. Bone Joint J 96-B:1370–1377. https://doi.org/10.1302/0301-620X.96B10.32914
Merchant TC, Dietz FR (1989) Long-term follow-up after fractures of the tibial and fibular shafts. J Bone Jt Surg Am 71:599–606
Ryan SP, Tornetta P 3rd, Dielwart C, Kaye-Krall E (2011) Knee pain correlates with union after tibial nailing. J Orthop Trauma 25:731–735. https://doi.org/10.1097/BOT.0b013e318213f587
Skoog A, Soderqvist A, Tornkvist H, Ponzer S (2001) 1-year outcome after tibial shaft fractures: results of a prospective fracture registry. J Orthop Trauma 15:210–215
Toivanen JA, Vaisto O, Kannus P et al (2002) Anterior knee pain after intramedullary nailing of fractures of the tibial shaft. A prospective, randomized study comparing two different nail-insertion techniques. J Bone Jt Surg Am 84-A:580–585
Vaisto O, Toivanen J, Kannus P, Jarvinen M (2008) Anterior knee pain after intramedullary nailing of fractures of the tibial shaft: an eight-year follow-up of a prospective, randomized study comparing two different nail-insertion techniques. J Trauma 64:1511–1516. https://doi.org/10.1097/TA.0b013e318031cd27
Nyland J, Bealle DP, Kaufer H, Johnson DL (2001) Long-term quadriceps femoris functional deficits following intramedullary nailing of isolated tibial fractures. Int Orthop 24:342–346
Larsen P, Elsoe R, Laessoe U et al (2016) Decreased QOL and muscle strength are persistent 1 year after intramedullary nailing of a tibial shaft fracture: a prospective 1-year follow-up cohort study. Arch Orthop Trauma Surg 136:1395–1402. https://doi.org/10.1007/s00402-016-2537-2
Larsen P, Laessoe U, Rasmussen S et al (2017) Asymmetry in gait pattern following tibial shaft fractures—a prospective 1-year follow-up study of 49 patients. Gait Posture 51:47–51. https://doi.org/10.1016/j.gaitpost.2016.09.027
Larsen P, Lund H, Laessoe U et al (2014) Restrictions in quality of life after intramedullary nailing of tibial shaft fracture: a retrospective follow-up study of 223 cases. J Orthop Trauma 28:507–512. https://doi.org/10.1097/BOT.0000000000000031
Bhattacharyya T, Seng K, Nassif NA, Freedman I (2006) Knee pain after tibial nailing: the role of nail prominence. Clin Orthop Relat Res 449:303–307. https://doi.org/10.1097/01.blo.0000223976.91089.08
Butcher JL, MacKenzie EJ, Cushing B et al (1996) Long-term outcomes after lower extremity trauma. J Trauma 41:4–9
Court-Brown CM, Gustilo T, Shaw AD (1997) Knee pain after intramedullary tibial nailing: its incidence, etiology, and outcome. J Orthop Trauma 11:103–105
Dogra AS, Ruiz AL, Marsh DR (2002) Late outcome of isolated tibial fractures treated by intramedullary nailing: the correlation between disease-specific and generic outcome measures. J Orthop Trauma 16:245–249
Ekeland A, Thoresen BO, Alho A et al (1988) Interlocking intramedullary nailing in the treatment of tibial fractures. A report of 45 cases. Clin Orthop Relat Res 231:205–215
Holder-Powell HM, Rutherford OM (1999) Unilateral lower limb injury: its long-term effects on quadriceps, hamstring, and plantarflexor muscle strength. Arch Phys Med Rehabil 80:717–720
Keating JF, Orfaly R, O’Brien PJ (1997) Knee pain after tibial nailing. J Orthop Trauma 11:10–13
Marsh JL Agel J et al. STF (2007) Fracture and dislocation classification compendium—2007: Orthopadic Trauma Association Classification, Database and Outcome Committee. J Orthop Trauma 1–133
EUROQOL EQ-5D. https://www.euroqol.org. Accessed 20 Jul 2016
KOOS questionnary [KOOS web site]. https://www.koos.nu. Accessed June 12, 2011.
von Elm E, Altman DG, Egger M et al (2014) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. Int J Surg 12:1495–1499. https://doi.org/10.1016/j.ijsu.2014.07.013
Sorensen J, Davidsen M, Gudex C et al (2009) Danish EQ-5D population norms. Scand J Public Health 37:467–474. https://doi.org/10.1177/1403494809105286
Paradowski PT, Bergman S, Sunden-Lundius A et al (2006) Knee complaints vary with age and gender in the adult population. Population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS). BMC Musculoskelet Disord 7:38. https://doi.org/10.1186/1471-2474-7-38
Parmar V, Shyam Kumar AJ, Harper WM (2006) Reliability of the GAITRite walkway system for the quantification of temporo-spatial parameters of gait in young and older people. Gait Posture 23:523. https://doi.org/10.1016/j.gaitpost.2005.06.001(author reply 524–525)
Oberg T, Karsznia A, Oberg K (1993) Basic gait parameters: reference data for normal subjects, 10–79 years of age. J Rehabil Res Dev 30:210–223
Patterson KK, Gage WH, Brooks D et al (2010) Evaluation of gait symmetry after stroke: a comparison of current methods and recommendations for standardization. Gait Posture 31:241–246. https://doi.org/10.1016/j.gaitpost.2009.10.014
Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16:494–502. https://doi.org/10.1136/ard.16.4.494
Yogev G, Plotnik M, Peretz C et al (2007) Gait asymmetry in patients with Parkinson’s disease and elderly fallers: when does the bilateral coordination of gait require attention? Exp brain Res 177:336–346. https://doi.org/10.1007/s00221-006-0676-3
McClure NS, Al SF, Xie F et al (2017) Instrument-defined estimates of the minimally important difference for EQ-5D-5L index scores. Value Heal 20:644–650. https://doi.org/10.1016/j.jval.2016.11.015
Roos EM, Lohmander LS (2003) The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes 1:64. https://doi.org/10.1186/1477-7525-1-64
Connelly CL, Bucknall V, Jenkins PJ et al (2014) Outcome at 12 to 22 years of 1502 tibial shaft fractures. Bone Jt J 96B:1370–1377. https://doi.org/10.1302/0301-620X.96B10.32914
Morris R, Pallister I, Trickett RW (2019) Measuring outcomes following tibial fracture. Injury 50:521–533. https://doi.org/10.1016/j.injury.2018.11.025
Vaisto O, Toivanen J, Kannus P, Jarvinen M (2004) Anterior knee pain and thigh muscle strength after intramedullary nailing of tibial shaft fractures: a report of 40 consecutive cases. J Orthop Trauma 18:18–23
Vaisto O, Toivanen J, Kannus P, Jarvinen M (2007) Anterior knee pain and thigh muscle strength after intramedullary nailing of a tibial shaft fracture: an 8-year follow-up of 28 consecutive cases. J Orthop Trauma 21:165–171. https://doi.org/10.1097/BOT.0b013e31803773cd
Gaston P, Will E, McQueen MM et al (2000) Analysis of muscle function in the lower limb after fracture of the diaphysis of the tibia in adults. J bone Jt Surg Br 82:326–331
Özbek EA, Kalem M, Kınık H (2019) Do the loss of thigh muscle strength and tibial malrotation cause anterior knee pain after tibia intramedullary nailing? Biomed Res Int 2019:3072105. https://doi.org/10.1155/2019/3072105
Macri F, Marques LF, Backer RC et al (2012) Validation of a standardised gait score to predict the healing of tibial fractures. J Bone Joint Surg Br 94:544–548. https://doi.org/10.1302/0301-620X.94B4.27927
Larsen P, Elsoe R, Graven-Nielsen T et al (2016) Local and widespread hyperalgesia after isolated tibial shaft fractures treated with intramedullary nailing. Pain Med 17:1174–1180. https://doi.org/10.1093/pm/pnv016
Bishop JA, Campbell ST, Eno J-JT, Gardner MJ (2018) Knee pain after intramedullary nailing of tibia fractures: prevalence, etiology, and treatment. J Am Acad Orthop Surg 26:e381–e387. https://doi.org/10.5435/JAAOS-D-18-00076
Funding
None.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflicts of interest to report. The authors did not receive benefits or grants in any form from a commercial part related directly or indirectly to the subject of this article.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Larsen, P., Eriksen, C.B., Stokholm, R. et al. Results following prolonged recovery show satisfactory functional and patient-reported outcome after intramedullary nailing of a tibial shaft fracture: a prospective 5-year follow-up cohort study. Arch Orthop Trauma Surg 141, 1303–1310 (2021). https://doi.org/10.1007/s00402-020-03608-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00402-020-03608-y