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The impact of hereditary multiple exostoses on quality of life, satisfaction, global health status, and pain

  • Orthopaedic Surgery
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Purpose

The aim of the study was to evaluate quality of life (QOL), global health status, pain, and level of satisfaction in patients with hereditary multiple exostoses (HME), and to correlate the association between the severity of diseases and age, sex, number of surgical procedures, and number of exostoses.

Methods

The data of 50 patients with HME were retrospectively evaluated and recorded. QOL was evaluated with the Short-Form Health Survey (SF-12) questionnaire, the 12-Item General Health Questionnaire (GHQ-12), and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-SF); intensity of pain was measured using the visual analogue scale (VAS). The association of age, gender, pain, quality of life, number of exostoses, and number of surgical procedures were evaluated and correlated.

Results

Mean number of exostoses in our patient’s cohort resulted 18.12 ± 8.60, and every patient underwent to a mean of 5.62 ± 5.74 surgical procedures for the exostoses. Mean VAS resulted 5.16 ± 2.90. Considering SF-12, mental (MCS) and physical (PCS) component resulted, respectively, 45.36 ± 10.76 and 38.73 ± 11.09, while GHQ-12 and Q-LES-Q-SF were 15.48 ± 4.70 and 45.28 ± 9.55, respectively. We found a significant positive correlation between the number of exostoses and the number of surgical procedures (p < 0.001), a significant positive correlation between the number of surgical procedures and GHQ-12 (p = 0.422) and VAS (p = 0.0011), and a negative correlation between the number of surgical procedures and PCS (p = 0.0257) and between age and GHQ-12 (p = 0.0385).

Conclusions

We can conclude that HME impact on patient quality of life as measured by the MCS and PCS scores similar to the disability associated with osteoarthritis in the mental component and tumors or diabetes as regards the physical component. Moreover, we found no difference in patients’ quality of life as regards number of exostoses, age, and surgical procedure, but we found that women have a worse response as regards the psychological side than men.

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Authors and Affiliations

  1. Università degli Studi di Milano, Milan, Italy

    Riccardo D’Ambrosi

  2. Centro Traumatologico Ortopedico, Unità Operativa Clinica Ortopedica e Traumatologica, Milan, Italy

    Riccardo D’Ambrosi, Camilla Caldarini & Renato Mario Facchini

  3. IRCCS Policlinico San Donato, San Donato Milanese, Italy

    Vincenza Ragone

  4. Department of Radiology, Second University of Naples, Naples, Italy

    Nicola Serra

  5. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

    Federico Giuseppe Usuelli

Authors
  1. Riccardo D’Ambrosi
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  2. Vincenza Ragone
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  3. Camilla Caldarini
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  4. Nicola Serra
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  5. Federico Giuseppe Usuelli
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  6. Renato Mario Facchini
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Corresponding author

Correspondence to Riccardo D’Ambrosi.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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The authors declare that they have no conflict of interest.

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D’Ambrosi, R., Ragone, V., Caldarini, C. et al. The impact of hereditary multiple exostoses on quality of life, satisfaction, global health status, and pain. Arch Orthop Trauma Surg 137, 209–215 (2017). https://doi.org/10.1007/s00402-016-2608-4

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  • DOI: https://doi.org/10.1007/s00402-016-2608-4

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