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Histological and biomechanical study of impacted cancellous allografts with cement in the femur: a canine model

  • Orthopaedic Surgery
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Introduction

An experimental canine model was used for quantitative histological study using bone morphometry and biomechanical study on impacted cancellous allografting with cement in revision total hip arthroplasty.

Materials and methods

The prosthesis had a collarless polished titanium alloy tapered stem with a head diameter of 15 mm. Twelve Beagle dogs were used. Cancellous bone grafts were obtained aseptically from the femoral condyles of other beagles. Histological examinations were performed up to 1 year after surgery. Biomechanical examinations were performed at 8 weeks after surgery.

Results

The new bone formation proceeded from the proximal part to the distal site of the femur in the long axis as well as from the host cortical bone to the cement layer. Bone morphometry showed that the mineral apposition rate was higher in the proximal site of the femur than in the distal site at 8 weeks after surgery, but no significant differences were observed at other times. The bone formation rate was higher in the proximal site of the femur at 8 weeks after surgery, while it increased in the distal site at 16 weeks postoperatively but had decreased at 1 year after surgery significantly. The load test at 8 weeks after surgery showed that there was no significant difference at all sites attached strain gauge between impacted cancellous allograft group and control group.

Conclusion

We concluded that biological replacement of the grafted bone by new bone settled at 1 year after surgery in this experimental model. However, the process was not completed.

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References

  1. van Biezen FC, ten Have BL, Verhaar JA (2000) Impaction bone-grafting of severely defective femora in revision total hip surgery. Acta Orthop 71:135–142

    Article  Google Scholar 

  2. Board TN, Rooney P, Kearney JN, Kay PR (2006) Impaction allografting in revision total hip replacement. J Bone Joint Surg Br 88:852–857

    Article  PubMed  CAS  Google Scholar 

  3. Coathup M, Smith N, Kingsley C, Buckland T, Dattani R, Ascroft P, Blunn G (2008) Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement. J Bone Joint Surg Br 90:246–253

    Article  PubMed  CAS  Google Scholar 

  4. Committee on care and use of laboratory animals of the Institute of Laboratory Animal Resources (1985) Guide for the care and use of laboratory animals. (NIH publication No. 85–23) National Institutes of Health, Bethesda

  5. Eldridge JD, Smith EJ, Hubble MJ, Whitehouse SL, Learmonth ID (1997) Massive early subsidence following femoral impaction grafting. J Arthroplasty 12:535–540

    Article  PubMed  CAS  Google Scholar 

  6. Gie GA, Linder L, Ling RS, Simon JP, Slooff TJ, Timperley AJ (1993) Impacted cancellous allografts and cement for revision total hip arthroplasty. J Bone Joint Surg Br 75:14–21

    PubMed  CAS  Google Scholar 

  7. Gotoh T, Yasunaga Y, Takahashi K, Ochi M (2004) Biomechanical analysis and quantitative analysis of bone scintigraphy on thrust plate hip prosthesis. Archives Orthop Trauma Surg 124:357–362

    Google Scholar 

  8. Halliday BR, English HW, Timperley AJ, Gie GA, Ling RS (2003) Femoral impaction grafting with cement in revision total hip replacement. Evolution of the technique and results. J Bone Joint Surg Br 85:809–817

    PubMed  CAS  Google Scholar 

  9. Hisatome T, Yasunaga Y, Takahashi K, Ochi M (2004) Bone remodeling after impacted cancellous allograft in revision hip arthroplasty based on 99 mTc-MDP bone scintigraphy. Archives Orthop Trauma Surg 124:52–55

    Article  Google Scholar 

  10. Hofmann GO, Falk C, Wangemann T (1997) Immunological transformations in the recipient of grafted allogeneic human bone. Arch Orthop Trauma Surg 116:143–150

    Article  PubMed  CAS  Google Scholar 

  11. Jacob HAC (1997) Biomechanical principles and design details of the thrust plate prosthesis. In: Huggler AH, Jacob HAC (eds) the thrust plate prosthesis. Springer, Berlin, pp 25–47

    Google Scholar 

  12. Karrholm J, Hultmark P, Carlsson L, Malchau H (1999) Subsidence of a non-polished stem in revisions of the hip using impaction allograft. J Bone Joint Surg Br 81:135–142

    Article  PubMed  CAS  Google Scholar 

  13. Linder L (2000) Cancellous impaction grafting in the human femur: histological and radiographic observations in 6 autopsy femurs and 8 biopsies. Acta Orthop 71:543–552

    Article  CAS  Google Scholar 

  14. Ling RS, Timperley AJ, Linder L (1993) Histology of cancellous impaction grafting in the femur. A case report. J Bone Joint Surg Br 75:693–696

    PubMed  CAS  Google Scholar 

  15. Mikhail WE, Wretenberg PF, Weidenhielm LR, Mikhail MN (1999) Complex cemented revision using polished stem and morselized allograft. Minimum 5-years’ follow-up. Arch Orthop Trauma Surg 119:288–291

    Article  PubMed  CAS  Google Scholar 

  16. Monier-Faugere MC, Geng Z, Qi Q, Arnala I, Malluche HH (1996) Calcitonin prevents bone loss but decreases osteoblastic activity in ovariohysterectomized beagle dogs. J Bone Miner Res 11:446–455

    PubMed  CAS  Google Scholar 

  17. Nelissen RG, Bauer TW, Weidenhielm LR, LeGolvan DP, Mikhail WE (1995) Revision hip arthroplasty with the use of cement and impaction grafting. Histological analysis of four cases. J Bone Joint Surg. Am 77:412–422

    PubMed  CAS  Google Scholar 

  18. Oomori H, Imura S, Gesso H, Tanaka Y, Ichihashi K, Takedani H, Okumura Y, Boh A (1993) Biomechanical study of femoral stem load transfer in cementless total hip arthroplasty, using a non-linear two-dimentional finite element method. In: Imura S, Akamatsu N, Azuma H, Sawai K, Tanaka S (eds) Hip biomechanics. Springer, Tokyo, pp 239–253

    Google Scholar 

  19. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nonmenclature, symbols and units. Report of the ASBMR Histomorphometry Nonmenclature Committee. J Bone Miner Res 2:595–611

    PubMed  CAS  Google Scholar 

  20. Recker RR, Kimmel DB, Parfitt AM, Davies KM, Keshawarz N, Hinders S (1988) Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females. J Bone Miner Res 3:133–144

    Article  PubMed  CAS  Google Scholar 

  21. Schreurs BW, Buma P, Huiskes R, Slagter JL, Slooff TJ (1994) Morsellized allografts for fixation of the hip prosthesis femoral component. A mechanical and histological study in the goat. Acta Orthop 65:267–275

    Article  CAS  Google Scholar 

  22. Schreurs BW, Arts JJ, Verdonschot N, Buma P, Slooff TJ, Gardeniers JW (2005) Femoral component revision with use of impaction bone-grafting and a cemented polished stem. J Bone Joint Surg Am 87:2499–2507

    Article  PubMed  Google Scholar 

  23. Sorensen J, Ullmark G, Langstrom B, Nilsson O (2003) Rapid bone and blood flow formation in impacted morselized allografts. Acta Orthop 74:633–643

    Article  Google Scholar 

  24. Tagil M (2000) The morselized impacted bone graft, animal experiments on proteins, impaction and load. Act Orthop Scand Suppl 290:1–40

    CAS  Google Scholar 

  25. Ullmark G, Linder L (1998) Histology of the femur after cancellous impaction grafting using a Charnley prosthesis. Arch Orthop Trauma Surg 117:170–172

    Article  PubMed  CAS  Google Scholar 

  26. Ullmark G, Obrant KJ (2002) Histology of impacted bone-graft incorporation. J Arthroplasty 17:150–157

    Article  PubMed  CAS  Google Scholar 

  27. Ullmark G, Hallin G, Nilsson O (2002) Impacted corticocancellous allografts and cement for femoral revision of total hip arthroplasty using Lubinus and Charnley prostheses. J Arthroplasty 17:325–334

    Article  PubMed  Google Scholar 

  28. Ullmark G, Sorensen J, Langstrom B, Nilsson O (2007) Bone regeneration 6 years after impaction bone grafting. Acta Orthop 78:201–205

    Article  PubMed  Google Scholar 

Download references

Acknowledgment

This research was partially funded by a grant from the Japanese Hip Research Foundation in 1997.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

    O. Omoto, Y. Yasunaga, N. Adachi, M. Deie & M. Ochi

  2. Department of Artificial Joints and Biomaterials, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Y. Yasunaga

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  1. O. Omoto
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  2. Y. Yasunaga
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  3. N. Adachi
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  4. M. Deie
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  5. M. Ochi
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Correspondence to Y. Yasunaga.

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Omoto, O., Yasunaga, Y., Adachi, N. et al. Histological and biomechanical study of impacted cancellous allografts with cement in the femur: a canine model. Arch Orthop Trauma Surg 128, 1357–1364 (2008). https://doi.org/10.1007/s00402-008-0732-5

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  • DOI: https://doi.org/10.1007/s00402-008-0732-5

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