Abstract
Osteosarcoma usually metastasizes to the lung or the bone, but very rarely to the soft tissue. There have been few reports of osteosarcoma patients with long-term survival after the soft tissue metastasis. We report a case of osteosarcoma in a 18-year-old man, who presented with a solitary skeletal muscle metastasis in the right vastus lateralis as the second relapse of the disease. The patient underwent excision surgery without adjuvant chemotherapy, and remains free of the disease for over 34 months after the surgery.
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Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, Kotz R, Salzer-Kuntschik M, Werner M, Winkelmann W, Zoubek A, Jurgens H, Winkler K (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20:776–790
Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A, Picci P (2006) Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer 106:1154–1161
Damron TA, Heiner J (2000) Distant soft tissue metastases: a series of 30 new patients and 91 cases from the literature. Ann Surg Oncol 7:526–534
Rao UN, Hanan SH, Lotze MT, Karakousis CP (1998) Distant skin and soft tissue metastases from sarcomas. J Surg Oncol 69:94–98
Tuoheti Y, Okada K, Osanai T, Nishida J, Ehara S, Hashimoto M, Itoi E (2004) Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases. Jpn J Clin Oncol 34:210–214
Kempf-Bielack B, Bielack SS, Jurgens H, Branscheid D, Berdel WE, Exner GU, Gobel U, Helmke K, Jundt G, Kabisch H, Kevric M, Klingebiel T, Kotz R, Maas R, Schwarz R, Semik M, Treuner J, Zoubek A, Winkler K (2005) Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the cooperative osteosarcoma study group (COSS). J Clin Oncol 23:559–568
Bacci G, Briccoli A, Longhi A, Ferrari S, Mercuri M, Faggioli F, Versari M, Picci P (2005) Treatment and outcome of recurrent osteosarcoma: experience at Rizzoli in 235 patients initially treated with neoadjuvant chemotherapy. Acta Oncol 44:748–755
Hawkins DS, Arndt CA (2003) Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy. Cancer 98:2447–2456
Daw NC, Billups CA, Rodriguez-Galindo C, McCarville MB, Rao BN, Cain AM, Jenkins JJ, Neel MD, Meyer WH (2006) Metastatic osteosarcoma. Cancer 106:403–412
Peh WC, Shek TW, Wang SC, Wong JW, Chien EP (1999) Osteogenic sarcoma with skeletal muscle metastases. Skeletal Radiol 28:298–304
Wolf R, Wolf RF, Hoekstra HJ (1999) Recurrent, multiple, calcified soft tissue metastases from osteogenic sarcoma without pulmonary involvement. Skeletal Radiol 28:710–713
Herman TE, McAlister WH (2004) Multifocal synchronous osteosarcoma with cutaneous and muscle metastases. Pediatr Radiol 34:671–672
Hirota T, Konno K, Fujimoto T, Ohta H, Kato S, Hara K (1999) Unusual late extrapulmonary metastasis in osteosarcoma. Pediatr Hematol Oncol 6:545–549
Damron TA, Morganti C, Yang Y, Hojnowski L, Cherny R (2000) Metastasis of osteosarcoma to soft tissue. a case report. J Bone Joint Surg 82A:1634–1638
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Yamada, K., Yatabe, Y. & Sugiura, H. Osteosarcoma with skeletal muscle metastasis. Arch Orthop Trauma Surg 128, 695–699 (2008). https://doi.org/10.1007/s00402-007-0375-y
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DOI: https://doi.org/10.1007/s00402-007-0375-y