Abstract
We develop a bead–spring Brownian dynamics model for simulating the topological interactions between polymers and thin obstacles and apply this method to electrophoretically translating DNA strands interacting with an immovable post. The use of a bead–spring method allows for the simulation of entanglement interactions of polymer chains too long to be simulated using bead–rod or pearl necklace models. Using stiff “FENE-Fraenkel” springs, we are able to model short chains as well. Our new method determines the shortest distance between a spring and the post, calculates a repulsive force inversely related to this distance using an exponential potential, and corrects for the rare situation when a spring passes beyond the post despite the repulsive interaction. As an example problem, we consider single-chain collisions with a single post in weak electric fields. We explore a wide range of chain lengths (25–1,515 Kuhn steps), and we find that the average delay produced by the collision is a function of both the chain length and the Peclet number. Chains of all lengths reach the same upper limit at high Peclet number, but they follow separate curves with similar slopes at lower Peclet number. Our results are consistent with published results for a 25-Kuhn-step chain at Peclet number Pe = 10. Our new method is a general one that allows us to compute the effects of entanglements in systems with rare entanglements and long chains that cannot be simulated by other more microscopic methods.
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References
Barron AE, Soane DS, Blanch HW (1993) Capillary electrophoresis of DNA in uncross-linked polymer solutions. J Chromatogr A 652:3–16
Chopra M, Larson RG (2002) Brownian dynamics simulations of isolated polymer molecules in shear flow near adsorbing and nonadsorbing surfaces. J Rheol 46:831–862
de Carmejane O, Yamaguchi Y, Todorov TI, Morris MD (2001) Three-dimensional observation of electrophoretic migration of dsDNA in semidilute hydroxy-ethylcellulose solution. Electrophoresis 22:2433–2441
Doyle PS, Bibette J, Bancaud A, Viovy JL (2002) Self-assembled magnetic matrices for DNA separation chips. Science 295:2237
Grassia P, Hinch EJ (1996) Computer simulations of polymer chain relaxation via Brownian motion. J Fluid Mech 308:255–288
Hsieh C, Jain S, Larson RG (2006) Brownian dynamics simulations with stiff FENE-Fraenkel springs as approximations to rods in bead–spring models. J Chem Phys 124:044911
Kumar S, Larson RG (2001) Brownian dynamics simulations of flexible polymers with spring–spring repulsions. J Chem Phys 114:6937–6941
Marko JF, Siggia ED (1995) Stretching DNA. Macromolecules 28:8759–8770
Nixon GI, Slater GW (1994) DNA electrophoretic collisions with single obstacles. Phys Rev E 50:5033–5038
Padding JT, Briels WJ (2002) Time and length scales of polymer melts studied by coarse-grained molecular dynamics simulations. J Chem Phys 117:925–943
Patel PD, Shaqfeh ESG (2003) A computational study of DNA separations in sparse disordered and periodic arrays of posts. J Chem Phys 118:2941–2951
Randall GC, Doyle PS (2004) Electrophoretic collision of a DNA molecule with an insulating post. Phys Rev Lett 93:058102
Saville PM, Sevick EM (1999) Collision of a field-driven polymer with a finite sized obstacle; a Brownian dynamics simulation. Macromolecules 32:892–899
Somasi M, Khomami B, Woo NJ, Hur JS, Shaqfeh ESG (2002) Brownian dynamics simulations of bead–rod and bead–spring chains: numerical algorithms and coarse-graining issues. J Non Newton Fluid Mech 108:227–255
Starkweather ME, Muthukumar M, Hoagland DA (1998) Single chain entanglement: a Monte Carlo simulation of dilute solution capillary electrophoresis. Macromolecules 31:5495–5501
Volkmuth WD, Austin RH (1992) DNA electrophoresis in microlithographic arrays. Nature 358:600–602
Volkmuth WD, Duke T, Wu MC, Austin RH (1994) DNA electrodiffusion in a 2D array of posts. Phys Rev Lett 72:2117–2120
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Holleran, S.P., Larson, R.G. Using spring repulsions to model entanglement interactions in Brownian dynamics simulations of bead–spring chains. Rheol Acta 47, 3–17 (2008). https://doi.org/10.1007/s00397-007-0189-4
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DOI: https://doi.org/10.1007/s00397-007-0189-4