Abstract
In this work, magnetic hyperthermia, i.e., heating induced by an alternating magnetic field acting on a magnetic suspension, is considered in three main aspects. The first one regards the implementation of a simple device for producing AC magnetic fields. The second contribution concerns the comparison of the hyperthermia response (measured by the specific absorption rate (SAR)) of magnetite nanoparticles of two different sizes and of raw particles vs. polyelectrolyte-coated ones. An improvement is observed of the SAR values when the pH is fixed away from the isoelectric point or when the ionic strength is kept at low values. The addition of a polymer enhances significantly the stability of the suspensions and so does with the SAR values. Finally, we describe the implementation of a sort of magnetic hyperthermia applicator, avoiding the necessity of placing the magnetic sample inside the coil and making it of more practical use.
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Davis ME (2012) Fighting cancer with nanoparticle medicines—the nanoscale matters. MRS Bull 37:828–835. doi:10.1557/mrs.2012.202
Ferrari M (2008) Beyond drug delivery. Nat Nanotechnol 3:131–132. doi:10.1038/nnano.2008.46
Caruso F, Hyeon T, Rotello VM (2012) Nanomedicine. Chem Soc Rev 41:2537–2538. doi:10.1039/c2cs90005j
Petros RA, DeSimone JM (2010) Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 9:615–627. doi:10.1038/nrd2591
Nagahara LA, Ferrari M, Grodzinski P (2009) Nanofunctional materials in cancer research: challenges, novel methods, and emerging applications. MRS Bull 34:406–408. doi:10.1557/mrs2009.116
Pankhurst QA, Connolly J, Jones SK, Dobson J (2003) Applications of magnetic nanoparticles in biomedicine. J Phys D-Appl Phys 36:R167–R181. doi:10.1088/0022-3727/36/13/201
Pankhurst QA, Thanh NTK, Jones SK, Dobson J (2009) Progress in applications of magnetic nanoparticles in biomedicine. J Phys D-Appl Phys 42:224001. doi:10.1088/0022-3727/42/22/224001
Kalia S, Kango S, Kumar A, Haldorai Y, Kumari B, Kumar R (2014) Magnetic polymer nanocomposites for environmental and biomedical applications. Colloid Polym Sci 292:2025–2052. doi:10.1007/s00396-014-3357-y
Schmidt AM (2007) Thermoresponsive magnetic colloids. Colloid Polym Sci 285:953–966. doi:10.1007/s00396-007-1667-z
Northrup EF (1926) Inductive heating. J Franklin Inst 201:221–244. doi:10.1016/s0016-0032(26)90811-9
Strutt MJO (1927) On the theory of inductive heating. Annalen Der Physik 82:0605–0617
Goldman L, Dreffer R (1976) Microwaves, magnetic iron particles and lasers as a combined test model for investigation of hyperthermia treatment of cancer. Arch Dermatol Res 257:227–232
Block JB, Tabbarah H, Isacoff W, Drakes TP (1979) Chemotherapy of unresectable or recurrent metastatic malignant melanomas: an update. J Dermatol Surg Onc 5:118–123. doi:10.1111/j.1524-4725.1979.tb00624.x
Gilchrist RK, Medal R, Shorey WD, Hanselman RC, Parrott JC, Taylor CB (1957) Selective inductive heating of lymph nodes. Ann Surg 146:596–606. doi:10.1097/00000658-195710000-00007
Riechert T, Gabriel E, Asai A (1967) The removal of biologic tissue by means of inductive heating. Acta Neurochir 16:299–300
Lacroix LM, Malaki RB, Carrey J, Lachaize S, Respaud M, Goya GF, Chaudret B (2009) Magnetic hyperthermia in single-domain monodisperse FeCo nanoparticles: evidences for Stoner-Wohlfarth behavior and large losses. J Appl Phys 105:023911. doi:10.1063/1.3068195
Deatsch AE, Evans BA (2014) Heating efficiency in magnetic nanoparticle hyperthermia. J Magn Magn Mater 354:163–172. doi:10.1016/j.jmmm.2013.11.006
Kim DH, Nikles DE, Johnson DT, Brazel CS (2008) Heat generation of aqueously dispersed CoFe2O4 nanoparticles as heating agents for magnetically activated drug delivery and hyperthermia. J Magn Magn Mater 320:2390–2396. doi:10.1016/j.jmmm.2008.05.023
Deatsch AE, Evans BA (2013) Effect of concentration on heating efficiency of magnetic nanoparticles for application in magnetic hyperthermia. Biophys J 104:674A–674A. doi:10.1016/j.jmmm.2013.11.006
Atkinson WJ, Brezovich IA, Chakraborty DP (1984) Usable frequencies in hyperthermia with thermal seeds. IEEE Trans Biomed Eng 31:70–75. doi:10.1109/tbme.1984.325372
Laurent S, Dutz S, Hafeli UO, Mahmoudi M (2011) Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Adv Inteface Colloid Sci 166:8–23. doi:10.1016/j.cis.2011.04.003
Coffey WT, Crothers DSF, Dormann JL, Geoghegan LJ, Kalmykov YP, Waldron JT, Wickstead AW (1995) Effect of an oblique magnetic field on the superparamagnetic relaxation time. Phys Rev B 52:15951–15965. doi:10.1103/PhysRevB.52.15951
Coffey WT, Crothers DSF, Dormann JL, Geoghegan LJ, Kalmykov YP, Waldron JT, Wickstead AW (1995) The effect of an oblique magnetic-field on the superparamagnetic relaxation-time. J Magn Magn Mater 145:L263–L267. doi:10.1016/0304-8853(94)00863-9
Coffey WT, Crothers DSF, Kalmykov YP, Waldron JT (1995) Constant-magnetic-field effect in Neel relaxation of single-domain ferromagnetic particles. Phys Rev B 51:15947–15956. doi:10.1103/PhysRevB.51.15947
Obaidat IM, Issa B, Haik Y (2015) Magnetic properties of magnetic nanoparticles for efficient hyperthermia. Nanomaterials 5:63–89. doi:10.3390/nano5010063
Leslie Pelecky DL, Rieke RD (1996) Magnetic properties of nanostructured materials. Chem Mater 8:1770–1783. doi:10.1021/cm960077f
Hergt R, Hiergeist R, Hilger I, Kaiser WA, Lapatnikov Y, Margel S, Richter U (2004) Maghemite nanoparticles with very high AC-losses for application in RF-magnetic hyperthermia. J Magn Magn Mater 270:345–357. doi:10.1016/j.jmmm.2003.09.001
Rosensweig RE (2002) Heating magnetic fluid with alternating magnetic field. J Magn Magn Mater 252:370–374. doi:10.1016/s0304-8853(02)00706-0
Ruta S, Chantrell R, Hovorka O (2015) Unified model of hyperthermia via hysteresis heating in systems of interacting magnetic nanoparticles. Sci Rep 5:9090. doi:10.1038/srep09090
Hergt R, Dutz S, Zeisberger M (2010) Validity limits of the Neel relaxation model of magnetic nanoparticles for hyperthermia. Nanotechnol 21:015706. doi:10.1088/0957-4484/21/1/015706
Dutz S, Hergt R (2013) Magnetic nanoparticle heating and heat transfer on a microscale: basic principles, realities and physical limitations of hyperthermia for tumour therapy. Int J Hyperthermia 29:790–800. doi:10.3109/02656736.2013.822993
Dutz S, Hergt R (2014) Magnetic particle hyperthermia—a promising tumour therapy? Nanotechnology 25:452001. doi:10.1088/0957-4484/25/45/452001
Bakoglidis KD, Simeonidis K, Sakellari D, Stefanou G, Angelakeris M (2012) Size-dependent mechanisms in AC magnetic hyperthermia response of iron-oxide nanoparticles. IEEE Trans Magn 48:1320–1323. doi:10.1109/tmag.2011.2173474
Roca AG, Vallejo-Fernandez G, O’Grady K (2011) An analysis of minor hysteresis loops of nanoparticles for hyperthermia. IEEE Trans Magn 47:2878–2881. doi:10.1109/tmag.2011.2157112
Mehdaoui B, Meffre A, Carrey J, Lachaize S, Lacroix L-M, Gougeon M, Chaudret B, Respaud M (2011) Optimal size of nanoparticles for magnetic hyperthermia: a combined theoretical and experimental study. Adv Funct Mater 21:4573–4581. doi:10.1002/adfm.201101243
Fortin J-P, Wilhelm C, Servais J, Menager C, Bacri J-C, Gazeau F (2007) Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J Am Chem Soc 129:2628–2635. doi:10.1021/ja067457e
Gonzales-Weimuller M, Zeisberger M, Krishnan KM (2009) Size-dependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia. J Magn Magn Mater 321:1947–1950. doi:10.1016/j.jmmm.2008.12.017
Wang XM, Gu HC, Yang ZQ (2005) The heating effect of magnetic fluids in an alternating magnetic field. J Magn Magn Mater 293:334–340. doi:10.1016/j.jmmm.2005.02.028
Guibert C, Dupuis V, Peyre V, Fresnais J (2015) Hyperthermia of magnetic nanoparticles: experimental study of the role of aggregation. J Phys Chem C 119:28148–28154. doi:10.1021/acs.jpcc.5b07796
Massart R (1981) Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE T Magn 17:1247–1248. doi:10.1109/tmag.1981.1061188
Iglesias GR, Ruiz-Moron LF, Insa Monesma J, Duran JDG, Delgado AV (2007) An experimental method for the measurement of the stability of concentrated magnetic fluids. J Colloid Interf Sci 311:475–480. doi:10.1016/j.jcis.2007.03.063
Pineiro-Redondo Y, Banobre-Lopez M, Pardinas-Blanco I, Goya G, Lopez-Quintela MA, Rivas J (2011) The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles. Nanoscale Res Lett 6:383. doi:10.1186/1556-276x-6-383
Acknowledgments
Financial support for this work from Junta de Andalucía, Spain (project PE2012-FQM-0694), University of Granada-CEI Biotic (BS27.2015), MICINN, Spain (project FIS2013-47666-C03-01-R), FEDER Funds, EU, and RYC-2014-16901 (MINECO) is gratefully acknowledged.
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Iglesias, G., Delgado, A., Kujda, M. et al. Magnetic hyperthermia with magnetite nanoparticles: electrostatic and polymeric stabilization. Colloid Polym Sci 294, 1541–1550 (2016). https://doi.org/10.1007/s00396-016-3918-3
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DOI: https://doi.org/10.1007/s00396-016-3918-3