Skip to main content

Advertisement

SpringerLink
Log in

Rheological characterization of multi-component hydrogel based on carboxymethyl cellulose: insight into its encapsulation capacity and release kinetics towards ibuprofen

  • Original Contribution
  • Published:
Colloid and Polymer Science Aims and scope Submit manuscript

Abstract

We report the synthesis of semi-interpenetrating polymer network (semi-IPN) hydrogel composed of carboxymethyl cellulose (CMC), linear polyvinylpyrrolidone (PVP), acrylic acid (AA) and α-cyclodextrin (CD) by free-radical solution polymerization in presence of hydrogen peroxide as the initiator and its characterization by FTIR, SEM and Rheology. The formulated hydrogel is thermoreversible, and its rheological parameters like gelation temperature, gelation time, elastic modulus and stress were studied as a function of CD concentrations. Swelling ability of the hydrogel decreases while as the drug encapsulation and loading capacities enhance with increase in CD wt%. The partitioning of ibuprofen between regions of different polarity within the hydrogel was studied by spectrofluorimetry. The ability of hydrogel with 0.04 wt% of CD to release ibuprofen spanned over the time period of 2 h and was modelled in light of various kinetic models.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Hatice KC (2005) Synthesis of persulfate containing poly (N-vinyl-2-pyrrolidone) (PVP) hydrogels in aqueous solutions by g-induced radiation. Radiat Phys Chem 72:703–710

    Article  Google Scholar 

  2. Krishna Rao KSV, Naidu BVK, Subha MCS, Sairam M, Aminabhavi TM (2006) Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil. Carbohydr Polym 66:333–344

    Article  Google Scholar 

  3. Myung D, Waters D, Wiseman M, Duhamel PE, Noolandi J, Ta CN (2008) Progress in the development of interpenetrating polymer network hydrogels. Polym Adv Technol 19:647–657

    Article  CAS  Google Scholar 

  4. Kiatkamjornwong S, Mongkolsawat K, Sonsuk M (2002) Synthesis and property characterization of cassava starch grafted poly [acrylamide-co- (maleic acid)] superabsorbent via γ-irradiation. Polymer 43:3915–3924

    Article  CAS  Google Scholar 

  5. Opdahl A, KimSH KTS, Marmo C, Somorjai GA (2003) Surface mechanical properties of pHEMA contact lenses: viscoelastic and adhesive property changes on exposure to controlled humidity. J Biomed Mater Res A 67:350–356

    Article  Google Scholar 

  6. Yang X, Zhu Z, Liu Q, Chen X, Ma M (2008) Effects of PVA, agar contents, and irradiation doses on properties of PVA/ws-chitosan/glycerol hydrogels made by γ-irradiation followed by freeze-thawing. Radiat Phys Chem 77:954–960

    Article  CAS  Google Scholar 

  7. Qiu Y, Park K (2001) Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev 53(3):321–339

    Article  CAS  Google Scholar 

  8. Lee KY, Mooney DJ (2001) Hydrogels for tissue engineering. Chem Rev 101(7):1869–1879

    Article  CAS  Google Scholar 

  9. Jones A, Vaughan D (2005) Hydrogel dressings in the management of a variety of wound types: a review. J Orthop Nurs 9(Supplement 1):S1–S11

    Article  Google Scholar 

  10. Bharali JD, Shaoo SK, Mozumdar S, Maitra A (2003) Cross-linked polyvinylpyrrolidone nanoparticles: a potential carrier for hydrophilic drugs. J Colloid Interface Sci 258:415–423

    Article  CAS  Google Scholar 

  11. Vasir JK, Tambwekar K, Garg S (2003) Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm 255:13–32

    Article  CAS  Google Scholar 

  12. Chirila TV, Rakoczy PE, Garrett KL, Lou XCostanble IJ (2002) The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials 23:321–342

    Article  CAS  Google Scholar 

  13. Gulyuz U, Okay O (2013) Self-healing polyacrylic acid hydrogels. Soft Matter 9:10287

    Article  CAS  Google Scholar 

  14. Nguyena MK, Alsberg E (2014) Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine. Prog Polym Sci 39:1235–1265

    Article  Google Scholar 

  15. Sahiner N (2013) Soft and flexible hydrogel templates of different sizes andvarious functionalities for metal nanoparticle preparationand their use in catalysis. Prog Polym Sci 38:1329–1356

    Article  CAS  Google Scholar 

  16. Wang W, WangQ WA (2011) pH-Responsive Carboxymethylcellulose-g Poly(sodium acrylate)/Polyvinylpyrrolidone Semi-IPN Hydrogels with Enhanced Responsive and Swelling Properties. Macromol Res 19:57–65

    Article  CAS  Google Scholar 

  17. Peng X-W, Ren J-L, Lin-XinZhong FP, Sun R-C (2011) Xylan-rich Hemicelluloses-graft-Acrylic Acid Ionic Hydrogels with Rapid Responses to pH, Salt, and Organic Solvents. J Agric Food Chem 59:8208–8215

    Article  CAS  Google Scholar 

  18. Omidian H, Park K (2012) Fundamentals and Applications of Controlled Release Drug Delivery. Adv Deliv Sci Technol 75:105

    Google Scholar 

  19. Guo JH, Skinner GW, Harcum WW, Barnum PE (1998) Pharmaceutical applications of naturally occurring water-soluble polymers. Pharm Sci Technol Today 1:254

    Article  CAS  Google Scholar 

  20. Omidian H, et al (2005) Hydrogels having enhanced elasticity and mechanical strengthproperties in US patent, 6,960,617

  21. Omidian H, Rocca JG (2006) Formation of strong superporous hydrogels in US patent, 7, 056,957

  22. Omidian H, Rocca JG, Park K (2006) Elastic, superporous hydrogel hybrids of polyacrylamide and sodium alginate. Macromol Biosci 6:703–710

    Article  CAS  Google Scholar 

  23. Dhar N, Akhlaghi SP, Tam KC (2012) Biodegradable and biocompatible polyampholyte microgels derived from chitosan, carboxymethyl cellulose and modified methyl cellulose. Carbohydr Polym 87:101–109

    Article  CAS  Google Scholar 

  24. Manakker F, Vermonden T, Nostrum CF, Hennink WE (2009) Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical /biomedical applications. Biomacromolecules 10:3157

    Article  Google Scholar 

  25. Jiang GB, Quan D, Liao K, Wang H (2006) Novel Polymer Micelles Prepared from Chitosan Grafted Hydrophobic Palmitoyl Groups for Drug Delivery. Mol Pharm 3:152–160

    Article  CAS  Google Scholar 

  26. Liu TY, Lin YL (2010) Novel pH-sensitive chitosan-based hydrogel for encapsulating poorly water-soluble drugs. Acta Biomater 6:1423–1429

    Article  CAS  Google Scholar 

  27. Wang J, Somasundaran P (2005) Adsorption and conformation of carboxymethyl cellulose at solid–liquid interfaces using spectroscopic, AFM and allied techniques. J Colloid Interface Sci 291:75–83

    Article  CAS  Google Scholar 

  28. Gajare P, Patil C, Kalyane N, Pore Y (2009) Effect 0f Hydrophilic Polymers on Pioglitazone Complexation with Hydroxypropyl-β-Cyclodextrin. Dig J Nanomater Biostruct 4:891–897

    Google Scholar 

  29. Kulbida A, Ramos MN, Rasanen M, Nieminen J, Schrems O, Fausto R (1995) Rotational Isomerism in Acrylic Acid- A Combined Matrix-isolated IR, Raman and ab initio Molecular Orbital Study. J Chem Soc Faraday Trans 91:1571–1585

    Article  CAS  Google Scholar 

  30. Oxley J, Smith J, Brady J, Dubnikova F, Kosloff R, Zeiri L, Zeiri Y (2008) Raman and Infrared Fingerprint Spectroscopy of Peroxide-Based Explosives. Appl Spectrosc 62:906

    Article  CAS  Google Scholar 

  31. McMurry J (2007) Organic chemistry with biological approach. Cengage Learning. Inc. ISBN-13: 978-0-495-39144-9

  32. Aouada FA, de Moura MR, Rubira AF, Muniz EC, Fernandes PRG, Mukai H, da Silveira ACF, Itri R (2006) Birefringent hydrogels based on PAAm and lyotropic liquid crystal: optical, morphological and hydrophilic characterization. Eur Polym J42:2781–2790

    Article  Google Scholar 

  33. Yang X, Liu Q, Chen X, Yu F, Zhu Z (2008) Investigation of PVA/ws-chitosan hydrogels prepared by combined c-irradiation and freeze-thawing. Carbohydr Polym 73:401–408

    Article  CAS  Google Scholar 

  34. Moura MJ, Figueiredo MM, Gil MH (2007) Rheological Study of Genipin Cross-Linked Chitosan Hydrogels. Biomacromolecules 8:3823–3829

    Article  CAS  Google Scholar 

  35. Hou Q, De Bank PA, Shakesheff KM (2004) Injectable scaffolds for tissue regeneration. J Mater Chem 14:1915–1923

    Article  CAS  Google Scholar 

  36. Hafeti A, Amsden B (2002) Biodegradable injectable in situ forming drug delivery systems. J Control Release 80:9–28

    Article  Google Scholar 

  37. Fechine GJM, Barros JAG, Alcantara MR, Catalani LH (2006) Fluorescence polarization and rheological studies of the poly (N-vinyl-2-pyrrolidone) hydrogels produced by UV radiation. Polymer 47:2629–2633

    Article  CAS  Google Scholar 

  38. Sharma SC, Shrestha LK, Tsuchiya K, Sakai K, Sakai H, Abe M (2009) Viscoelastic Wormlike Micelles of Long Polyoxyethylene Chain Phytosterol with Lipophilic Nonionic Surfactant in Aqueous Solution. J Phys Chem B 113:3043–3050

    Article  CAS  Google Scholar 

  39. BirdRB ARC, Hassager O (1987) Dynamics of polymeric liquids—volume 1: fluid mechanics, 2nd edn. John Wiley, New York

    Google Scholar 

  40. Rubinstein M, Colby RH (2003) Polymer Physics(Oxford University Press)

  41. Anseth KS, Bowman CN, Brannon-Peppas L (1996) Mechanical properties of hydrogels and their experimental determination. Biomaterials 17:1647–1657

    Article  CAS  Google Scholar 

  42. Kavanagh GM, Ross-Murphy Simon B (1998) Rheological characterisation of polymer gels. Prog Polym Sci 23:533–562

    Article  CAS  Google Scholar 

  43. Ghosh K, Shu XZ, Mou R, Lombardi J, Prestwich GD, Rafailovich MH, Clark RAF (2005) Rheological Characterization of in Situ Cross-Linkable Hyaluronan Hydrogels. Biomacromolecules 6:2857–2865

    Article  CAS  Google Scholar 

  44. Kono H (2014) Characterization and properties of carboxymethylcellulose hydrogels crosslinked by polyethyleneglycol. Carbohydr Polym 106:84–93

    Article  CAS  Google Scholar 

  45. Nho YC, Park JS, Lim YM (2014) Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives. Polymers 6:890–898

    Article  Google Scholar 

  46. Costa P, Lobo JMS (2001) Modeling and comparison of dissolution profiles. Eur J Pharm Sci 13:123–133

    Article  CAS  Google Scholar 

  47. Higuchi T (1963) Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 52:1145–1149

    Article  CAS  Google Scholar 

  48. Cowley JD, Pasha I (1981) The fluorescence of some dipolar NN-dialkyl-4-(dichloro-1,3,5-triazinyl)anilines. Part 2. Temperature and solvent effects on the radiationless decay of an intramolecular charge-transfer excited singlet state. J Chem Soc Perkin Trans 2:918

    Article  Google Scholar 

  49. Cowley JD, Okame E, Todd RST (1991) Triazinylaniline derivatives as fluorescence probes. Part 1. Absorption and fluorescence in organic solvents and in aqueous media in relation to twisted intramolecular charge-transfer state formation, hydrogen bonding, and protic equilibria. J Chem Soc Perkin Trans 2:1495

    Article  Google Scholar 

  50. El-Daly SA, Abdel-Kader MH, Issa RM, El-Sherbini EA (2003) Influence of solvent polarity and medium acidity on the UV_/Vis spectral behavior of 1-methyl-4-[4-amino-styryl] pyridinum iodide. Spectrochim Acta A 59:405–411

    Article  Google Scholar 

Download references

Acknowledgments

AAD acknowledges the Department of Science and Technology (DST), Govt. of India, for providing funds under the FIST scheme to the Department of Chemistry, University of Kashmir, for procuring various instruments.

Author information

Authors and Affiliations

  1. Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, 190 006, J&K, India

    Masrat Maswal, Oyais Ahmad Chat & Aijaz Ahmad Dar

Authors
  1. Masrat Maswal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Oyais Ahmad Chat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aijaz Ahmad Dar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aijaz Ahmad Dar.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Maswal, M., Chat, O.A. & Dar, A.A. Rheological characterization of multi-component hydrogel based on carboxymethyl cellulose: insight into its encapsulation capacity and release kinetics towards ibuprofen. Colloid Polym Sci 293, 1723–1735 (2015). https://doi.org/10.1007/s00396-015-3545-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00396-015-3545-4

Keywords

Search

Navigation