Abstract
Biodegradable N-maleyl gelatin (N-MAGEL) was synthesized with gelatin (GEL) and maleic anhydride (MAH) by acylation. With Bis-acrylamide (Bis) cross-linker, a series of cross-linked poly (N-isopropylacrylamide-co-N-maleyl gelatin) [P(NIPAAm-co-N-MAGEL)] hydrogels were prepared, and their lower critical solution temperature (LCST), water content, swelling/deswelling kinetics, drug delivery behaviors, and enzymatic degradation properties were investigated. As weight ratios of N-MAGEL/NIPAAm in hydrogel were increasing, water content increased, and it had no significant influence on LCST of hydrogel in spite of the weight ratios reaching 30:70. In the swelling/deswelling kinetics, hydrogels with higher weight ratios of N-MAGEL/NIPAAm exhibited faster swelling rate and slower deswelling rate. Drug delivery for bovine serum albumin (BSA) research indicated that increasing weight ratios of N-MAGEL/NIPAAm in hydrogels contribute to raising release time and cumulative release ratios. Lastly, hydrogels with higher weight ratios of N-MAGEL/NIPAAm degraded rapidly in phosphate-buffered saline (PBS) containing papain.
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This research was supported by the National Natural Science Foundation of China (No. 20876081) and the Science Foundation of Shandong Province (ZR2012BM015).
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Zheng, Y., Wang, B., Liu, M. et al. Synthesis and characterization of biodegradable thermoresponsive N-maleyl gelatin-co-P(N-isopropylacrylamide) hydrogel cross-linked with Bis-acrylamide for control release. Colloid Polym Sci 293, 1615–1621 (2015). https://doi.org/10.1007/s00396-015-3544-5
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DOI: https://doi.org/10.1007/s00396-015-3544-5