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Structure and acoustical properties control of magnetite/PLA composite microbubbles

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Abstract

Poly(lactic acid) (PLA) microbubbles and magnetite/PLA composite microbubbles with various structures and controllable average size were prepared by a modified double emulsion–solvent evaporation process, and sound attenuation spectrum was performed to investigate the influence of size, composite structure, and magnetite loading on the acoustical properties of microbubbles. With the increase of time or energy of the emulsification, the inner structure of composite microbubbles changed continuously from honeycomb to solid structure, accompanied by the change of surface morphology and the decrease of average particle size. The sound attenuation and resonance frequency of concentric microbubbles were higher than those of other structures, while microbubbles with multicavities had the lowest sound attenuation and resonance frequency. The difference in the acoustical properties was related to their different structures and water permeability. In vitro ultrasonography of composite microbubbles showed a higher video intensity than that of PLA microbubbles, which was consistent with their sound attenuation spectra.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (no. 20904032, 10974093), Science and Technology Committee of Shanghai (project no. 05XD14015) and Shanghai Education Committee (project no. 09YZ103), State Key Lab of Metal Matrix Composites and the Shanghai Jiao Tong University Foundation of Medicine-Engineering Cross-Disciplinary Research (project no. YG2009ZD202). We thank Instrumental Analysis Center of SJTU for the assistance on measurements. We also thank Shanghai Sunny New Technology Development Co. Ltd. for their support.

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Authors and Affiliations

  1. State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China

    Rong Lu, Bin Xu, Ke Tao, Hongjing Dou & Kang Sun

  2. Institute of Acoustics, Nanjing University, Nanjing, 210093, China

    Yuanyuan Qiu

  3. Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201210, People’s Republic of China

    Yuqi Zhang & Lanping Wu

  4. Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, People’s Republic of China

    Kun Sun

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  1. Rong Lu
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  2. Bin Xu
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  3. Ke Tao
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  4. Hongjing Dou
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  5. Yuanyuan Qiu
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  6. Kang Sun
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  7. Yuqi Zhang
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  8. Lanping Wu
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  9. Kun Sun
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Correspondence to Hongjing Dou or Kang Sun.

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Lu, R., Xu, B., Tao, K. et al. Structure and acoustical properties control of magnetite/PLA composite microbubbles. Colloid Polym Sci 290, 63–71 (2012). https://doi.org/10.1007/s00396-011-2523-8

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  • DOI: https://doi.org/10.1007/s00396-011-2523-8

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