Abstract
Polychloromethylstyrene nanoparticles of sizes from 12.0 ± 2.3 to 229.6 ± 65 nm were prepared by the emulsion and miniemulsion polymerization of chloromethylstyrene in an aqueous continuous phase in the presence of potassium persulfate as initiator, sodium octylbenzenesulfonate as surfactant, and hexadecane as costabilizer for the miniemulsion polymerization process only. The influence of various polymerization parameters (e.g., concentration of the monomer, initiator, the crosslinker monomer, and the surfactant) on the properties of the particles (e.g., size, size distribution, and yield) has been elucidated. The polychloromethylstyrene nanoparticles formed via the emulsion polymerization mechanism possess smaller diameter and size distribution than those formed under similar conditions via the miniemulsion polymerization mechanism. Other differences between these two polymerization mechanisms have also been elucidated. For future study, we wish to use these nanoparticles for the covalent immobilization of bioactive reagents such as proteins to the surface of these nanoparticles for various biomedical applications.
Similar content being viewed by others
References
Behan N, Birkinshaw C, Clarke N (2001) Biomaterials 22:1335–1344
Saxena V, Sadoqi M, Shao J (2004) Int J Pharm 278:293–301
Venier-Julienne MC, Benoit JP (1996) Pharm Acta Helv 71:121–128
Chonde Y, Liu LJ, Krieger IM (1980) J Appl Polym Sci 25:2407–2416
Boguslavsky L, Baruch S, Margel S (2005) J Colloid Interface Sci 289:71–85
Chen YW, Kang ET, Neoh KG, Greiner A (2005) Adv Funct Mater 15:113–117
Cen L, Neoh KG, Cai Q, Kang ET (2006) J Colloid Interface Sci 300:190–199
Galperin A, Margel D, Baniel J, Dank G, Biton H, Margel S (2007) Biomaterials 28:4461–4468
Asua JM (2002) Prog Polym Sci 27:1283–1346
Kermabon-Avon G, Bressy C, Margaillan A (2009) Eur Polym J 45:1208–1216
Schork FJ, Poehlein GW, Wang S, Reimers J, Rodrigues J, Samer C (1999) Colloids Surf A 153:39–45
Taniguchi T, Takeuchi N, Kobaru S, Nakahira T (2008) J Colloid Interface Sci 327:58–62
Tiarks F, Landfester K, Antonietti M (2001) Langmuir 17:5775–5780
Yildiz U, Landfester K (2008) Polymer 49:4930–4934
Csetneki I, Faix MK, Szilagyi A, Kovacs AL, Nemeth Z, Zrinyi M (2004) J Polym Sci Part A Polym Chem 42:4802–4808
Erdem B, Sudol ED, Dimonie VL, El-Aasser MS (2000) J Polym Sci Part A Polym Chem 38:4431–4440
Qiu J, Charleux B, Matyjaszewski K (2001) Prog Polym Sci 26:2083–2134
Barrere M, Ganachaud F, Bendejacq D, Dourges MA, Maitre C, Hemery P (2001) Polymer 42:7239–7246
Barrere M, Landfester K (2003) Macromolecules 36:5119–5125
Taden A, Antonietti M, Landfester K (2003) Macromol Rapid Commun 24:512–516
Anderson CD, Sudol ED, El-Aasser MS (2003) J Appl Polym Sci 90:3987–3993
Bechthold N, Landfester K (2000) Macromolecules 33:4682–4689
Baruch-Sharon S, Margel S (2008) J Appl Polym Sci 108:3727–3737
Baruch-Sharon S, Margel S (2009) Colloid Polym Sci 287:859–869
Monticone V, Favoriti P, Lemordant D, Treiner C (2000) Langmuir 16:258–264
Ardizzone S, Orlandi M (1995) J Electroanal Chem 391:181–185
Okubo M, Ando M, Yamada A, Katsuta Y, Matsumoto T (1981) J Polym Sci Lett Ed 19:143–147
Okubo M, Katsuta Y, Matsumoto T (1982) J Polym Sci Lett Ed 20:45–51
Goldshtein J, Margel S (2009) Polymer 50:3422–3430
Bamnolker H, Margel S (1996) J Polym Sci Part A Polym Chem 34:1857–1871
Martinez A, Gonzalez C, Porras M, Gutierrez JM (2005) Colloids Surf A 270:67–71
Sajjadi S, Brooks BW (1999) J Polym Sci Part A Polym Chem 37:3957–3972
Acknowledgments
These studies were partially supported by a Minerva Grant (Microscale & Nanoscale Particles and Films). The authors would like to thank Dr. Yossi Gofer from Bar-Ilan University, Department of Chemistry for his help in the XPS study.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Baruch-Sharon, S., Margel, S. Synthesis and characterization of polychloromethylstyrene nanoparticles of narrow size distribution by emulsion and miniemulsion polymerization processes. Colloid Polym Sci 288, 869–877 (2010). https://doi.org/10.1007/s00396-010-2209-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00396-010-2209-7