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Synthesis of amphiphilic polysiloxanes and their properties for formation of nano-aggregates

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Abstract

In this study, we prepared amphiphilic polysiloxanes by introduction of hydrophobic and hydrophilic parts into a water-soluble poly(3-aminopropyl)siloxane. Fatty acid (lauroyl, myristoyl, palmitoyl, and stearoyl) chlorides and gluconolactone were employed as the reactants for the hydrophobic and hydrophilic parts, respectively. The reaction of the poly(3-aminopropyl)siloxane with fatty acid chlorides was performed in water/DMF, followed by the reaction with gluconolactone in DMSO, giving the corresponding amphiphilic polysiloxanes. The results of the NMR spectra, SEM observations, and DLS measurements indicated the formation of nano-aggregates from the amphiphilic polysiloxanes in water. These analytical data also suggested that the structures and functionalities of the hydrophobic parts affected the formation properties of the nano-aggregates.

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Acknowledgment

T.N. thanks Dr. Tetsuji Yamaoka and Dr. Atsushi Mahara of the National Cardiovascular Center for DLS measurement.

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Authors and Affiliations

  1. Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima, 890-0065, Japan

    Norio Iwakiri, Yoshiro Kaneko & Jun-Ichi Kadokawa

  2. National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan

    Takehiro Nishikawa

Authors
  1. Norio Iwakiri
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  2. Takehiro Nishikawa
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  3. Yoshiro Kaneko
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  4. Jun-Ichi Kadokawa
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Correspondence to Jun-Ichi Kadokawa.

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Iwakiri, N., Nishikawa, T., Kaneko, Y. et al. Synthesis of amphiphilic polysiloxanes and their properties for formation of nano-aggregates. Colloid Polym Sci 287, 577–582 (2009). https://doi.org/10.1007/s00396-009-2005-4

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  • DOI: https://doi.org/10.1007/s00396-009-2005-4

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