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Interaction between the antibacterial compound, oleuropein, and model membranes

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Abstract

Oleuropein, a secoiridoid glycoside extracted from the olive tree, Olea europaea L., has been described as showing antibacterial properties. However, the exact mechanism of these antimicrobial properties is not yet well understood. In the present study, we have studied the interaction of oleuropein with phosphatidylglycerol (PG) as a model membrane for Staphylococcus aureus (S. aureus) (Gram-positive bacteria) and phosphatidylethanolamine and Escherichia coli (E. coli) lipid extract as a model membrane for E. coli (Gram-negative bacteria). The study has been carried out using monolayers as model membranes and using kinetics at constant area and compression isotherms with Brewster angle microscopy (BAM) observations. The results show that oleuropein interacts in higher extent with PG monolayers, which is related with its stronger antibacterial effect against Gram-positive bacteria. The effects on the membrane are probably produced at the cell surface because oleuropein did not form stable mixed monolayers with the lipids assayed at the air/water interface.

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Acknowledgment

We wish to thank Mrs. Susanne Osbahr for the drawings of Fig. 12.

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Authors and Affiliations

  1. Department of Physicochemistry, Faculty of Pharmacy, Universidad de Barcelona, Av. Joan XXIII s.n., 08028, Barcelona, Spain

    Jorge Casas-Sanchez, M. Asuncion Alsina & Concepció Mestres

  2. Procter and Gamble Service GmbH, Sulzbacherstrasse 40, 65823, Schwalbach am Taunus, Germany

    Jorge Casas-Sanchez & Mathias K. Herrlein

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  1. Jorge Casas-Sanchez
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  2. M. Asuncion Alsina
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  3. Mathias K. Herrlein
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  4. Concepció Mestres
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Correspondence to Concepció Mestres.

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Casas-Sanchez, J., Alsina, M.A., Herrlein, M.K. et al. Interaction between the antibacterial compound, oleuropein, and model membranes. Colloid Polym Sci 285, 1351–1360 (2007). https://doi.org/10.1007/s00396-007-1693-x

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  • DOI: https://doi.org/10.1007/s00396-007-1693-x

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