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Preparation and release profiles of pH/temperature-responsive carboxymethyl chitosan/P(2-(dimethylamino) ethyl methacrylate) semi-IPN amphoteric hydrogel

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Abstract

Thermo- and pH-responsive semi-IPN polyampholyte hydrogels were prepared by using carboxymethyl chitosan and P(2-(dimethylamino) ethyl methacrylate) with N N'-Methylenebisacrylamide (BIS) as crosslinking agent. It was found that the semi-IPN hydrogel shrunk most at the isoelectric point (IEP) and swelled when pH deviated from the IEP. Its swelling ratio dramatically decreased between 30 and 50 °C at pH 6.8 buffer solution. It also showed good reversibility. The UV results showed that when the pH values of drug release medium were 3.7, 6.8, and 9 at 25 °C, the cumulative release rates reached 83.1, 51.5, and 72.2%, respectively. The release rate of coenzyme A (CoA) was higher at 50 °C than 37 and 25 °C at pH 6.8 solution. The release rate decreased with increasing the content of carboxymethyl chitosan at 25 °C in pH 6.8 solution. The results showed that semi-IPN hydrogel seems to be of great promise in pH/temperature drug delivery systems.

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Acknowledgment

The authors are thankful to the National Natural Science Foundation of China for providing the fund (grant number 50273010).

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Authors and Affiliations

  1. Institute of Fine Chemical and Engineering, Henan University, Kaifeng, Henan, 475001, People’s Republic of China

    Baolin Guo, Jinfang Yuan, Li Yao & Qingyu Gao

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  1. Baolin Guo
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  2. Jinfang Yuan
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  3. Li Yao
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  4. Qingyu Gao
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Correspondence to Qingyu Gao.

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Guo, B., Yuan, J., Yao, L. et al. Preparation and release profiles of pH/temperature-responsive carboxymethyl chitosan/P(2-(dimethylamino) ethyl methacrylate) semi-IPN amphoteric hydrogel. Colloid Polym Sci 285, 665–671 (2007). https://doi.org/10.1007/s00396-006-1611-7

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  • DOI: https://doi.org/10.1007/s00396-006-1611-7

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