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A novel sol–gel strategy to prepare temperature-sensitive hydrogel for encapsulation of protein

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Abstract

A novel sol–gel strategy was proposed to prepare temperature-sensitive hydrogel including the copolymerization of N-isopropylacrylamide and 3-methacryloxypropyl-trimethoxy silane and then the hydrolysis and condensation of the linear polymers through the sol–gel process under extra-mild conditions. Bovine serum albumin, as a model protein, was loaded into the hydrogel matrix to investigate the encapsulation and release properties. Experimental results indicated that the preparation conditions were valuable for the loading and release of biomacromolecules.

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Acknowledgements

This work was financially supported by National Key Basic Research Program of China (973 Program) (G1999064703) and National Natural Science Foundation of China (20204009). The authors are grateful to Dr Z J Cao of College of Life Sciences of Wuhan University for his assistance in protein gel electrophoresis measurement.

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Authors and Affiliations

  1. Key Laboratory of Biomedical Polymers (Wuhan University), Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, People’s Republic of China

    Jian-Tao Zhang, Shi-Wen Huang & Ren-Xi Zhuo

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  1. Jian-Tao Zhang
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  2. Shi-Wen Huang
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  3. Ren-Xi Zhuo
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Correspondence to Ren-Xi Zhuo.

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Zhang, JT., Huang, SW. & Zhuo, RX. A novel sol–gel strategy to prepare temperature-sensitive hydrogel for encapsulation of protein. Colloid Polym Sci 284, 209–213 (2005). https://doi.org/10.1007/s00396-005-1357-7

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  • DOI: https://doi.org/10.1007/s00396-005-1357-7

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