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Dilatational properties and morphology of surface films spread from clinically used lung surfactants

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Abstract

The dilatational properties, structure, and morphology of the surface films spread at the air–water interface from complex lipid/protein systems were studied by measuring the surface pressure–area and surface potential–area isotherms, the surface rheological properties, and AFM images. The commercially available lung surfactants Alveofact, Curosurf, Survanta, and Exosurf were used as examples.

The isotherms of the studied lung surfactant surface films are compared with model lipid and protein monolayers spread from bulk solutions. On the basis of a simple rheological model, the values for the elasticity and the specific time of relaxation related to the reorganization processes occurring in the monolayers were calculated. The spread films of natural surfactants Curosurf and Alveofact show a high effectiveness of spreading and respreading under the conditions of this study. These observations were confirmed by AFM imaging.

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References

  1. Scarpelli EM (1998) Surfactants and the lining of the lung. Johns Hopkins University Press, Baltimore and London

  2. Notter RH (1988) Semin Perinatol 12:180

    CAS  PubMed  Google Scholar 

  3. Possmayer F (1984) In: Robertson B, van Golde LMG, Batenburg JJ (eds) Pulmonary surfactant. Elsevier, Amsterdam, p 295

  4. King RJ (1984) In: Robertson B, van Golde LMG, Batenburg JJ (eds) Pulmonary surfactant. Elsevier, Amsterdam, p 1

  5. Hawgoold S (1989) Am J Physiol 257:L13

    PubMed  Google Scholar 

  6. Suzuki Y, Kogishi K, Fujita Y (1990) In: von Wichert P, Muller B (eds) Basic research on lung surfactant. Karger, Basel, p 91

  7. Oosterlaken-Dijksterhuis MA, van Eijk M, van Buel BLM, van Golde LMG, Haagsman HP (1991) Biochem J 274:115

    CAS  PubMed  Google Scholar 

  8. Possmayer F, Cockshutt A, Yu SH (1990) In: Cosmi GC, Di Renzo GC, Anchesni MM (eds) The surfactant system of the lung. McMillan, London, pp 7–17

  9. Nottrer RH (2000) Lung surfactants: basic science and clinical applications, vol 149. Marcel Dekker, New York

    Google Scholar 

  10. Bernhard W, Mottaghian J, Gebert A, Rau GA, von der Hardt H, Poets CF (2000) Am J Respir Crit Care Med 162:1524

    CAS  PubMed  Google Scholar 

  11. Goerke J (1998) Biochim Biophys Acta 1408:79–89

    Article  CAS  PubMed  Google Scholar 

  12. Avery ME (1959) Am J Dis Child 97:517

    CAS  Google Scholar 

  13. Simatos GA, Forward KB, Morrow MR, Keough KMW (1990) Biochem 29:5807

    CAS  PubMed  Google Scholar 

  14. Keough KMW, Simatos G, Perez-Gil J, Nag K, Allwood LA, Morrow MR (1992) Thin Solid Films 210/211:720–722

    Google Scholar 

  15. Yu F, Possmayer SH (1992) Biochim Biophys Acta 1126:26

    Article  CAS  PubMed  Google Scholar 

  16. Creuwels LAJM, van Golde LMG, Hagsman HP (1997) Lung 175:1

    CAS  PubMed  Google Scholar 

  17. Panaiotov I, Ivanova Tz, Proust J, Boury F, Denizot B, Keough K, Taneva S (1996) Colloids Surf B Biointerfaces 6:243

    Article  CAS  Google Scholar 

  18. Mutafchieva R, Panaiotov I, Dimitrov DS (1984) Z Naturforsch C 39:965

    CAS  PubMed  Google Scholar 

  19. Ueno M, Samura K, Fukuda K, Takeo N, Takei T, Takahashi A, Fujiwara T, Asano H (1993) Colloids Surf B Biointerfaces 1:221

    Article  CAS  Google Scholar 

  20. Sasaki M, Iwate J (1990) Med Ass 42:883

    Google Scholar 

  21. Banerjee R, Bellare JR (2002) Int J Aromatherapy 12(1):40

    Article  Google Scholar 

  22. Panaiotov I (1987) Thesis, University of Sofia

  23. Dimitrov D, Panaiotov I (1975/76) Ann Univ Sofia Fac Chem 70:103

    Google Scholar 

  24. Dimitrov D, Panaiotov I, Richmond P, Ter-Minassian-Saraga L (1978) J Colloid Interface Sci 65:483

    CAS  Google Scholar 

  25. Panaiotov I, Dimitrov DS, Ter-Minassian-Saraga L (1979) J Colloid Interface Sci 72:49

    CAS  Google Scholar 

  26. Panaiotov I, Dimitrov DS, Ivanova М (1979) J Colloid Interface Sci 69:318

    CAS  Google Scholar 

  27. Panaiotov I, Sanfeld A, Bois A, Baret J F (1983) J Colloid Interface Sci 96:315

    CAS  Google Scholar 

  28. Loglio G, Tesej U, Miller R (1991) Colloids Surf 61:219

    CAS  Google Scholar 

  29. Taneva S, Keough KMW (1994) Biophys J 66:1137

    CAS  PubMed  Google Scholar 

  30. Taneva S, Keough KMW (1994) Biophys J 66:1149

    CAS  PubMed  Google Scholar 

  31. Taneva S, Keough KMW (1994) Biophys J 66:1158

    CAS  PubMed  Google Scholar 

  32. Ding J, Doudevski I, Warriner HE, Alig T, Lasadzinski J, Waring A, Sherman M (2003) Langmuir 19(5):1539–1550

    Article  CAS  Google Scholar 

Download references

Acknowledgment

The authors acknowledge financial support from the Foundation for Scientific Research of the University of Sofia (no. 682/2001); two of us Tz. Ivanova—the University of Angers and I. Panaiotov—INSERM (France).

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Authors and Affiliations

  1. Biophysical Chemistry Laboratory, University of Sofia, James Bourchier str. 1, 1126, Sofia, Bulgaria

    Tz. Ivanova, I. Minkov & I. Panaiotov

  2. Ingénierie de la Vectorisation Particulaire, INSERM ERIT-M, Immeuble IBT, 10 rue A. Boquel, 49100, Angers, France

    P. Saulnier & J. E. Proust

Authors
  1. Tz. Ivanova
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  2. I. Minkov
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  3. I. Panaiotov
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  4. P. Saulnier
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  5. J. E. Proust
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Correspondence to Tz. Ivanova.

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Ivanova, T., Minkov, I., Panaiotov, I. et al. Dilatational properties and morphology of surface films spread from clinically used lung surfactants. Colloid Polym Sci 282, 1258–1267 (2004). https://doi.org/10.1007/s00396-004-1073-8

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  • DOI: https://doi.org/10.1007/s00396-004-1073-8

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