Abstract
A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of KATP channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of KATP channels, reduced basal flow rates and eliminated the hyperemia associated with hypercapnia. These results implicate KATP channels as a functional link in the respiratory acidosis-induced increase in coronary flow.
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Received: 28 June 1999, Returned for revision: 11 August 1999, Revision received: 28 August 1999, Accepted: 29 September 1999
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Phillis, J., Song, D. & O'Regan, M. Mechanisms involved in coronary artery dilatation during respiratory acidosis in the isolated perfused rat heart. Basic Res Cardiol 95, 93–97 (2000). https://doi.org/10.1007/s003950050169
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DOI: https://doi.org/10.1007/s003950050169