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Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice

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Abstract

Purpose

Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its health benefits. This study aims to investigate whether MBC has beneficial benefits on the prevention of HFD-induced obesity and the modulation of gut microbiota in mice when it was supplemented in HFD.

Methods

Herein, male C57BL/6 J mice were fed with normal control diet, HFD, and HFD supplemented with MBC (3–6%, w/w) for 12 weeks. The changes in physiological, histological, biochemical parameters, serum endotoxin, proinflammatory cytokines, and gut microbiota composition of mice were determined to assess the ability of MBC to alleviate HFD-induced obesity and modulate gut microbiota disorders in mice.

Results

MBC supplementation exhibited significant reductions in the HFD-induced adiposity, fat accumulation, serum lipid levels, lipopolysaccharide, and proinflammatory cytokines concentrations (P < 0.05), which was accompanied by improvements in hepatic steatosis and adipocyte size. Especially, the elevated fasting blood glucose and insulin resistance were also significantly improved by MBC supplementation (P < 0.05). Furthermore, high-throughput sequencing of the 16S rRNA gene revealed that MBC could normalize HFD-induced gut microbiota dysbiosis. MBC not only could promote the bloom of Akkermansia, but also restore several HFD-dependent taxa (Blautia, Ruminiclostridium_9, Bilophila, and unclassified_f_Ruminococcaceae) back to normal status, co-occurring with the decreases in obesity-related indices.

Conclusions

This study provides evidence that MBC may be mainly responsible for the beneficial effects of whole mung bean on preventing the HFD-induced changes, thus enlarging the application value of MBC.

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Acknowledgements

This work was financially supported by the National Key Research and Development Program of China (2017YFD0401202).

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Authors and Affiliations

  1. College of Food Science and Nutritional Engineering, China Agricultural University, No.17, Qinghua East Road, Haidian District, Beijing, 100083, China

    Dianzhi Hou, Qingyu Zhao, Laraib Yousaf, Yong Xue & Qun Shen

  2. National Engineering Research Center for Fruit and Vegetable Processing, Beijing, 100083, China

    Dianzhi Hou, Qingyu Zhao, Laraib Yousaf, Yong Xue & Qun Shen

  3. Key Laboratory of Plant Protein and Grain Processing, China Agricultural University, Beijing, 100083, China

    Dianzhi Hou, Qingyu Zhao, Laraib Yousaf & Qun Shen

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Hou, D., Zhao, Q., Yousaf, L. et al. Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice. Eur J Nutr 60, 2029–2045 (2021). https://doi.org/10.1007/s00394-020-02395-x

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