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Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial

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Abstract

Background

Epidemiological studies have suggested that adipsin and visfatin are associated with the development of type 2 diabetes. This is the first study to investigate the effects of supplementation with purified anthocyanins on serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes.

Methods

A total of 160 participants with prediabetes or newly diagnosed diabetes (40–75 years old) were given 320 mg anthocyanins or placebo daily for 12 weeks in a randomized trial. Serum adipsin, serum visfatin, lipids and glycated hemoglobin A1c (HbA1c) were measured. The areas under the curve (AUCs) for glucose, insulin and C-peptide were determined before-and after-treatment by a standard 3-h 75 g oral glucose tolerance test (OGTT).

Results

Relatively significant increases in serum adipsin (net change 0.15 µg/mL [0.03, 0.27], p = 0.018) and decreases in visfatin (−3.5 ng/mL [−6.69, −0.31], p = 0.032) were observed between the anthocyanins and placebo groups. We also observed significant improvements in HbA1c (−0.11% [−0.22, −0.11], p = 0.033), apolipoprotein A-1 (apo A-1) (0.12 g/L [0.03, 0.21], p = 0.012) and apolipoprotein B (apo B) (−0.07 g/L [−0.14, −0.01], p = 0.033) in response to the anthocyanins intervention.

Conclusion

Purified anthocyanins supplementation for 12 weeks increased serum adipsin and decreased serum visfatin in patients with prediabetes or newly diagnosed diabetes.

Trial registration ClinicalTrials.gov, identifier: NCT02689765.

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Acknowledgments

The authors are grateful to the participants as well as the medical staff involved in this study.

Funding

This study was supported by the Key Project of National Natural Science Foundation of China (grant number 81730090) and the Health Technology Project of NanShan, ShenZhen (grant number 2019034).

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Authors and Affiliations

  1. Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74th ZhongShan Road II, GuangZhou, 510080, PR China

    Liping Yang, Yun Qiu, Wenhua Ling, Zhaomin Liu & Lili Yang

  2. Center for Chronic Disease Control, Nanshan, ShenZhen, PR China

    Liping Yang, Changyi Wang, Xiaolin Peng & Li Wang

  3. GuangDong Province, BaiYun Hospital, YueXiu District, GuangZhou, PR China

    Jianying Chen

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  1. Liping Yang
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  5. Lili Yang
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  8. Li Wang
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Contributions

Liping Yang carried out the trial and wrote the manuscript; Yun Qiu collected the raw data; Jianying Chen contributed to participant recruitment; Changyi Wang and Xiaolin Peng managed the project; Li Wang conducted the statistical analysis; Zhaomin Liu contributed to manuscript revision; Wenhua Ling and Lili Yang designed and supervised the study.

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Correspondence to Liping Yang.

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Yang, L., Qiu, Y., Ling, W. et al. Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial. Eur J Nutr 60, 1935–1944 (2021). https://doi.org/10.1007/s00394-020-02379-x

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