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The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study

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Abstract

Purpose

Chronic gastritis is observed in almost half world population. Traditional medications against chronic gastritis might produce adverse effects, so alternative nutritional strategies are needed to prevent the aggravation of gastric mucosal damage. The aim of this study is to evaluate the protective effect of the combination of wheat peptides and fucoidan (WPF) on adults diagnosed with chronic superficial gastritis in a randomized, double-blind, placebo-controlled clinical trial.

Methods

Participants were randomized to receive WPF (N = 53) or placebo (N = 53) once daily for 45 days. Pathological grading of gastric mucosal damage was scored using gastroscopy. Fecal samples were collected for the determination of calprotectin, short chain fatty acids (SCFA) levels and metagenomics analysis. Questionnaires for self-reported gastrointestinal discomforts, life quality and food frequency were collected throughout the study.

Results

WPF intervention reduced gastric mucosal damage in 70% subjects (P < 0.001). Significantly less stomach pain (P < 0.001), belching (P = 0.028), bloating (P < 0.001), acid reflux (P < 0.001), loss of appetite (P = 0.021), increased food intake (P = 0.020), and promoted life quality (P = 0.014) were reported in the WPF group. WPF intervention significantly decreased fecal calprotectin level (P = 0.003) while slightly increased fecal SCFAs level (P = 0.092). In addition, we found altered microbiota composition post-intervention with increased Bifidobacterium pseudocatenulatum (P = 0.032), Eubacterium siraeum (P = 0.036), Bacteroides intestinalis (P = 0.024) and decreased Prevotella copri (P = 0.055).

Conclusions

WPF intervention could be utilized as a nutritional alternative to mitigate the progression of chronic gastritis. Furthermore, WPF played an important role in altering gut microbial profile and SCFA production, which might benefit the lower gastrointestinal tract.

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Abbreviations

14C-UBT:

Carbon-14 urea breath test

CD:

Crohn’s disease

HP:

Helicobacter pylori

IBD:

Inflammatory bowel disease

QOL:

Quality of life

SCFA:

Short chain fatty acids

UC:

Ulcerative colitis

VAS:

Visual analog scale

WPF:

Combination of wheat peptides and fucoidan

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Acknowledgements

We thank Li Zhang from SPRIM China for their great work in coordinating the clinical trial.

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Authors and Affiliations

  1. Nutrilite Health Institute, Amway R&D Center, 720 Cailun Road, Shanghai, 201203, China

    Juntao Kan, Junrui Cheng, Yumin Liu, Liang Chen & Jun Du

  2. Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Leiming Xu

  3. Nutrilite Health Institute, Amway R&D Center, Ada, MI, 49355, USA

    Molly Hood

  4. Department of Gastroenterology, Jinhua Wenrong Hospital, Jinhua, 321013, Zhejiang, China

    Dingfu Zhong

  5. QuantiHealth, Beijing, 100070, China

    Meijiao Cheng

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  1. Juntao Kan
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The study was conducted according to the guidelines laid down in the 1964 Declaration of Helsinki and its later amendments. All procedures involving human subjects were reviewed and approved by the IRB of Shanghai Nutrition Society. Written informed consent was obtained from all participants.

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Kan, J., Cheng, J., Xu, L. et al. The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study. Eur J Nutr 59, 1655–1666 (2020). https://doi.org/10.1007/s00394-019-02020-6

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