Skip to main content

Advertisement

SpringerLink
Log in

Serum leptin and total dietary energy intake: the INTERLIPID Study

  • Original Contribution
  • Published:
European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Purpose

It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese–Americans in Hawaii and Japanese in Japan.

Methods

Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40–59 years from two population samples, one Japanese–American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25–29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake.

Results

In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m2 (P < 0.001).

Conclusion

Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1984) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432

    Article  Google Scholar 

  2. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI (1997) Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100:270–278

    Article  CAS  Google Scholar 

  3. Rosenbaum M, Leibel RL (1999) The role of leptin in human physiology. N Engl J Med 341:913–915

    Article  CAS  Google Scholar 

  4. Considine RV, Sinha MK, Heiman ML et al (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292–295

    Article  CAS  Google Scholar 

  5. Caro JF, Kolaczynski JW, Nyce MR et al (1996) Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348(9021):159–161

    Article  CAS  Google Scholar 

  6. Correia ML, Rahmouni K (2006) Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes Obes Metab 8:603–610

    Article  CAS  Google Scholar 

  7. Correia ML, Haynes WG, Rahmouni K, Morgan DA, Sivitz WI, Mark AL (2002) The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes 51:439–442

    Article  CAS  Google Scholar 

  8. Myers MG Jr, Heymsfield SB, Haft C et al (2012) Challenges and opportunities of defining clinical leptin resistance. Cell Metab 15:150–156

    Article  CAS  Google Scholar 

  9. Ueshima H, Okayama A, Saitoh S et al (2003) Differences in cardiovascular disease risk factors between Japanese in Japan and Japanese–Americans in Hawaii: the INTERLIPID study. J Hum Hypertens 17:631–639

    Article  CAS  Google Scholar 

  10. Okuda N, Ueshima H, Okayama A et al (2005) Relation of long chain n−3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese–American men in Hawaii: the INTERLIPID study. Atherosclerosis 178:371–379

    Article  CAS  Google Scholar 

  11. Stamler J, Elliott P, Dennis B et al (2003) INTERMAP: background, aims, design, methods, and descriptive statistics (nondietary). J Hum Hypertens 17:591–608

    Article  CAS  Google Scholar 

  12. Dennis B, Stamler J, Buzzard M et al (2003) INTERMAP: the dietary data—process and quality control. J Hum Hypertens 17:609–622

    Article  CAS  Google Scholar 

  13. Nakamura Y, Ueshima H, Okuda N et al (2008) Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study. Am J Clin Nutr 88:424–430

    CAS  Google Scholar 

  14. Kannel WB, Sorlie P (1979) Some health benefits of physical activity. The Framingham Study. Arch Intern Med 139:857–861

    Article  CAS  Google Scholar 

  15. Korbonits M, Trainer PJ, Little JA et al (1997) Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clin Endocrinol (Oxf) 46:751–757

    Article  CAS  Google Scholar 

  16. Poretsky L, Lesser M, Brillon D (2001) Lack of postprandial leptin peaks in patients with type 2 diabetes mellitus. Diabetes Obes Metab 3:105–111

    Article  CAS  Google Scholar 

  17. Broeder CE, Burrhus KA, Svanevik LS, Wilmore JH (1992) The effects of aerobic fitness on resting metabolic rate. Am J Clin Nutr 55:795–801

    CAS  Google Scholar 

  18. Licinio J, Mantzoros C, Negrão AB et al (1997) Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 3:575–579

    Article  CAS  Google Scholar 

  19. Schoeller DA, Cella LK, Sinha MK, Caro JF (1997) Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 100:1882–1887

    Article  CAS  Google Scholar 

  20. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269(5223):546–549

    Article  CAS  Google Scholar 

  21. Halaas JL, Gajiwala KS, Maffei M et al (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269(5223):543–546

    Article  CAS  Google Scholar 

  22. Pelleymounter MA, Cullen MJ, Baker MB et al (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269(5223):540–543

    Article  CAS  Google Scholar 

  23. Farooqi IS, Jebb SA, Langmack G et al (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341:879–884

    Article  CAS  Google Scholar 

  24. Heymsfield SB, Greenberg AS, Fujioka K et al (1999) Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282:1568–1575

    Article  CAS  Google Scholar 

  25. Westerterp-Plantenga MS, Saris WH, Hukshorn CJ, Campfield LA (2001) Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men. Am J Clin Nutr 74:426–434

    CAS  Google Scholar 

  26. Kissileff HR, Thornton JC, Torres MI et al (2012) Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr 95:309–317

    Article  CAS  Google Scholar 

  27. Larsson H, Elmståhl S, Berglund G, Ahrén B (1998) Evidence for leptin regulation of food intake in humans. J Clin Endocrinol Metab 83:4382–4385

    Article  CAS  Google Scholar 

  28. Murakami K, Sasaki S, Takahashi Y et al (2007) Nutrient and food intake in relation to serum leptin concentration among young Japanese women. Nutrition 23:461–468

    Article  CAS  Google Scholar 

  29. Chu NF, Spiegelman D, Yu J, Rifai N, Hotamisligil GS, Rimm EB (2001) Plasma leptin concentrations and four-year weight gain among US men. Int J Obes Relat Metab Disord 25:346–353

    Article  CAS  Google Scholar 

  30. Shek EW, Brands MW, Hall JE (1998) Chronic leptin infusion increases arterial pressure. Hypertension 31:409–414

    Article  CAS  Google Scholar 

  31. Nakamura Y, Ueshima H, Okuda N et al (2009) Relation of serum leptin to blood pressure of Japanese in Japan and Japanese–Americans in Hawaii. Hypertension 54:1416–1422

    Article  CAS  Google Scholar 

  32. Nicklas BJ, Katzel LI, Ryan AS, Dennis KE, Goldberg AP (1997) Gender differences in the response of plasma leptin concentrations to weight loss in obese older individuals. Obes Res 5:62–68

    Article  CAS  Google Scholar 

  33. Niskanen LK, Haffner S, Karhunen LJ, Turpeinen AK, Miettinen H, Uusitupa MI (1997) Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss. Eur J Endocrinol 137(61–6):7

    Google Scholar 

  34. Ramel A, Arnarson A, Parra D, Kiely M, Bandarra NM, Martinéz JA, Thorsdottir I (2010) Gender difference in the prediction of weight loss by leptin among overweight adults. Ann Nutr Metab 56:190–197

    Article  CAS  Google Scholar 

  35. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3424–3427

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The INTERMAP/INTERLIPID Study has been accomplished through the fine work of staff at local, national, and international centers. A partial listing of colleagues is in the acknowledgement of reference 10. This study was supported in part by a grant-in-aid of the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research: (A) 090357003, (C) 17590563, and (C) 19590655 in Japan and the Suntory Company; the Pacific Research Institute is supported by the Robert Perry Fund and the Hawaii Community Foundation. The INTERMAP Hawaii Center was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant 5-RO1-HL54868-03). The INTERMAP Study is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A. (Grant 2-RO1-HL50490), as well as national and local agencies in the four countries.

Conflict of interest

All authors have no conflict of interest.

Author information

Authors and Affiliations

  1. Cardiovascular Epidemiology, Kyoto Women’s University, 35 Imakumano Kitahiyoshi-cho, Higashiyama-ku, Kyoto, Kyoto, 605-8501, Japan

    Yasuyuki Nakamura

  2. Department of Health Science, Shiga University of Medical Science, Otsu, Japan

    Yasuyuki Nakamura, Hirotsugu Ueshima, Katsuyuki Miura, Yoshikuni Kita & Tanvir C. Turin

  3. The First Institute of Health Service, Japan Anti-Tuberculosis Association, Tokyo, Japan

    Nagako Okuda & Akira Okayama

  4. Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan

    Yoshitaka Murakami

  5. Department of Preventive Cardiology, National Cardiovascular Center, Suita, Japan

    Tomonori Okamura

  6. Department of Epidemiology and Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh

    Sohel R. Choudhry

  7. Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA

    Beatriz Rodriguez & J. David Curb

  8. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Jeremiah Stamler

Authors
  1. Yasuyuki Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hirotsugu Ueshima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nagako Okuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshitaka Murakami
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Katsuyuki Miura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yoshikuni Kita
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tomonori Okamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Akira Okayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Tanvir C. Turin
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sohel R. Choudhry
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Beatriz Rodriguez
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. J. David Curb
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Jeremiah Stamler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yasuyuki Nakamura.

Additional information

J. David Curb is deceased on January 8, 2012.

This study is conducted for the INTERLIPID Research Group.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakamura, Y., Ueshima, H., Okuda, N. et al. Serum leptin and total dietary energy intake: the INTERLIPID Study. Eur J Nutr 52, 1641–1648 (2013). https://doi.org/10.1007/s00394-012-0469-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00394-012-0469-3

Keywords

Search

Navigation