Skip to main content
SpringerLink
Log in

Association of dietary AGEs with circulating AGEs, glycated LDL, IL-1α and MCP-1 levels in type 2 diabetic patients

  • Original Contribution
  • Published:
European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Purpose

The association of dietary advanced glycation endproducts (AGEs) intake with the oxidative and inflammatory status in type 2 diabetic patients was examined.

Methods

Seventy-four healthy controls, 50 low AGEs intake and 68 high AGEs intake type 2 diabetic patients were requested to complete a 7-day dietary record. Blood levels of several oxidative and inflammatory biomarkers were determined.

Results

Diabetic patients with high AGEs intake had significantly elevated plasma levels of AGEs, HbA1c, low-density lipoprotein (LDL), LDL-cholesterol and glycated LDL than low AGEs intake patients and controls (P < 0.05). These high AGEs intake patients also had significantly increased plasma levels of 8-isoprostane, interleukin (IL)-1α, tumor necrosis factor-α, monocyte chemoattractant protein (MCP)-1 and lower superoxide dismutase (SOD) activity than low AGEs intake patients (P < 0.05). Correlation coefficients of dietary AGEs versus plasma AGEs, HbA1c, 8-isoprostane, IL-1α and MCP-1 were >0.6; but the correlation coefficient of dietary AGEs versus plasma SOD activity was <−0.6.

Conclusion

Increasing dietary AGEs intake might enrich circulating AGE level and contribute to oxidative and inflammatory progression under diabetic condition. The circulating 8-isoprostane, IL-1α and MCP-1 levels and SOD activity might be appropriate biomarkers used to evaluate dietary AGEs-associated oxidative and inflammatory stress.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H (1997) Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci USA 94:6474–6479

    Article  CAS  Google Scholar 

  2. Riviere S, Birlouez-Aragon I, Vellas B (1998) Plasma protein glycation in Alzheimer’s disease. Glycoconj J 15:1039–1042

    Article  CAS  Google Scholar 

  3. Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield EJ (2002) Inflammatory markers are induced by dietary glycotoxins: a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA 99:15596–15601

    Article  CAS  Google Scholar 

  4. Negrean M, Stirban A, Stratmann B, Gawlowski T, Horstmann T, Götting C, Kleesiek K, Mueller-Roesel M, Koschinsky T, Uribarri J, Vlassara H, Tschoepe D (2007) Effects of low- and high-advanced glycation endproduct meals on macro- and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus. Am J Clin Nutr 85:1236–1243

    CAS  Google Scholar 

  5. Uribarri J, Stirban A, Sander D, Cai W, Negrean M, Buenting CE, Koschinsky T, Vlassara H (2007) Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects. Diabetes Care 30:2579–2582

    Article  CAS  Google Scholar 

  6. Stirban A, Negrean M, Götting C, Uribarri J, Gawlowski T, Stratmann B, Kleesiek K, Koschinsky T, Vlassara H, Tschoepe D (2008) Dietary advanced glycation endproducts and oxidative stress: in vivo effects on endothelial function and adipokines. Ann N Y Acad Sci 1126:276–279

    Article  CAS  Google Scholar 

  7. Erbersdobler HF, Somoza V (2007) Forty years of furosine—forty years of using Maillard reaction products as indicators of the nutritional quality of foods. Mol Nutr Food Res 51:423–430

    Article  CAS  Google Scholar 

  8. Goldberg T, Cai W, Melpomeni P, Dardaine V, Baliga BS, Uribarri J, Vlassara H (2004) Advanced glycoxidation end products in commonly consumed foods. J Am Diet Ass 104:1287–1291

    Article  CAS  Google Scholar 

  9. Chao PC, Hsu CC, Yin MC (2009) Analysis of glycative products in sauces and sauce-treated foods. Food Chem 113:262–266

    Article  CAS  Google Scholar 

  10. Department of Health (1998) Taiwan nutrient databases 1998. Department of Health, Executive Yuan, Taipei, Taiwan

  11. Shea J, Randell E, Vasdev S, Wang PP, Roebothan B, Sun G (2007) Serum retinol-binding protein 4 concentrations in response to short-term overfeeding in normal-weight, overweight, and obese men. Am J Clin Nutr 86:1310–1315

    CAS  Google Scholar 

  12. Hsu CC, Huang CN, Hung YC, Yin MC (2004) Five cysteine-containing compounds have antioxidative activity in Balb/cA mice. J Nutr 134:149–152

    CAS  Google Scholar 

  13. Konishi M, Iwasa M, Araki J, Kobayashi Y, Katsuki A, Sumida Y, Nakagawa N, Kojima Y, Watanabe S, Adachi Y, Kaito M (2006) Increased lipid peroxidation in patients with non-alcoholic fatty liver disease and chronic hepatitis C as measured by the plasma level of 8-isoprostane. J Gastroenterol Hepatol 21:1821–1825

    Article  CAS  Google Scholar 

  14. Miyata T, Taneda S, Kawai R, Ueda Y, Horiuchi S, Hara M, Maeda K, Monnier VM (1996) Identification of pentosidine as a native structure for advanced glycation end products in β2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis. Proc Natl Acad Sci USA 93:2353–2358

    Article  CAS  Google Scholar 

  15. Wu Y, Monnier V, Friedlander M (1995) Reliable determination of furosine in human serum and dialysate proteins by high-performance liquid chromatography. J Chromatogr B 667:328–332

    Article  CAS  Google Scholar 

  16. Nourooz-Zadeh J, Tajaddini-Sarmadi J, Ling KL, Wolff SP (1996) Low-density lipoprotein is the major carrier of lipid hydroperoxides in plasma. Biochem J 313:781–786

    CAS  Google Scholar 

  17. Duell PB, Oram JF, Biermann EL (1990) Nonenzymatic glycation of HDL resulting in inhibition of high-affinity binding to cultured human fibroblasts. Diabetes 39:1257–1263

    Article  CAS  Google Scholar 

  18. Ahmed N (2005) Advanced glycation endproducts–role in pathology of diabetic complications. Diabetes Res Clin Pract 67:3–21

    Article  CAS  Google Scholar 

  19. Miyata T, Izuhara Y (2008) Inhibition of advanced glycation end products: an implicit goal in clinical medicine for the treatment of diabetic nephropathy? Ann N Y Acad Sci 1126:141–146

    Article  CAS  Google Scholar 

  20. Navarro-González JF, Milena FJ, Mora C, León C, García J (2006) Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotension-converting enzyme inhibition and pentoxifylline administration. Am J Nephrol 26:562–570

    Article  Google Scholar 

  21. Demircan N, Safran BG, Soylu M, Ozcan AA, Sizmaz S (2006) Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye 20:1366–1369

    Article  CAS  Google Scholar 

  22. Martinovic I, Abegunewardene N, Seul M, Vosseler M, Horstick G, Buerke M, Darius H, Lindemann S (2005) Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease. Circulation J 69:1484–1489

    Article  CAS  Google Scholar 

  23. Kreisberg RA (1998) Diabetic dyslipidemia. Am J Cardiol 82:67–73

    Article  Google Scholar 

  24. James PE, Lang D, Tufnell-Barret T, Milsom AB, Frenneaux MP (2004) Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin. Circ Res 94:976–983

    Article  CAS  Google Scholar 

  25. Veiraiah A (2005) Hyperglycemia, lipoprotein glycation and vascular disease. Angiology 56:431–438

    Article  Google Scholar 

  26. Isoda K, Folco E, Marwali MR, Ohsuzu F, Libby P (2008) Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis. Atherosclerosis 198:307–312

    Article  CAS  Google Scholar 

  27. Cipriani R, Sensi M, Gabriele A, Gatti A, Mandosi E, Di Mario U, Morano S (2004) The impairment of renal function is not associated to altered circulating vascular endothelial growth factor in patients with type 2 diabetes and hypertension. Diabetes Nutr Metab 17:90–94

    CAS  Google Scholar 

Download references

Acknowledgments

All authors would like to thank all subjects participated in this study.

Conflict of interest

None of the authors reports a conflict of interest.

Author information

Authors and Affiliations

  1. Department of Nutritional Science, Chung Shan Medical University, Taichung City, Taiwan

    Pei-chun Chao & Cheng-chin Hsu

  2. Department of Nutrition, Chung Shan Medical University Hospital, Taichung City, Taiwan

    Pei-chun Chao

  3. Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan

    Chien-ning Huang

  4. Department of Nutrition, China Medical University, 91, Hsueh-shih Rd., Taichung City, Taiwan

    Mei-chin Yin & Yu-ru Guo

  5. Department of Health and Nutrition Biotechnology, Asia University, Taichung County, Taiwan

    Mei-chin Yin

Authors
  1. Pei-chun Chao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chien-ning Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cheng-chin Hsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mei-chin Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu-ru Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mei-chin Yin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chao, Pc., Huang, Cn., Hsu, Cc. et al. Association of dietary AGEs with circulating AGEs, glycated LDL, IL-1α and MCP-1 levels in type 2 diabetic patients. Eur J Nutr 49, 429–434 (2010). https://doi.org/10.1007/s00394-010-0101-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00394-010-0101-3

Keywords

Search

Navigation