Abstract
Purpose
This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis.
Methods
The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test.
Results
Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected.
Conclusion
In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary.
Zusammenfassung
Ziel
Diese Studie hat zum Ziel, mit einer umfassenden Metaanalyse den Zusammenhang von cytokinen genetischen Polymorphismen mit dem Risiko für Morbus Behcet zu untersuchen.
Methoden
Embase und die PubMed-Datenbank, die den Zeitraum vom frühestmöglichen Jahr bis Mai 2015 abdecken, wurden durchsucht. Eine Gesamtzahl von 13 geeigneten Artikeln mit 2065 Morbus-Behcet-Patienten und 1559 Kontrollpersonen wurden untersucht. Chancenverhältnis OR (Odds Ratio) und ein Konfidenzintervall (CI) von 95 % wurden verwendet, um die Stärke des Zusammenhangs zu untersuchen. Ein möglicher Publikationsbias wurde mit Eggers linearem Regressionstest untersucht.
Ergebnisse
Die Metaanalyse weist auf Zusammenhänge zwischen IL‑6 rs1800795, IL‑12B rs3212227 und IL‑18 rs1946518 bei allen Versuchspersonen hin: IL‑18 rs1946518 beim dominanten Modell (IL‑18 rs1946518: OR = 0,48, 95 % CI: 0,34–0,70, P = 0.000) und beim homozygoten Modell (IL‑18 rs1946518: OR = 0,40, 95 % CI: 0,25–0,65, P = 0.000) und IL‑6 rs1800795 sowie IL‑12B rs3212227 beim dominanten Modell (IL‑6 rs1800795: OR = 0,53, 95 % CI: 0,39–0,72, P = 0.000; IL‑12B rs3212227: OR = 1,26, 95 % CI: 1,06–1,48, P = 0,007; IL‑18 rs1946518: OR = 0,46, 95 % CI: 0,33–0.65, P = 0.000). Es gab keinen signifikanten Beleg für Verbindungen von IL‑18 rs187238 Polymorphismus mit Verdacht auf Morbus Behcet.
Zusammenfassung
Zusammengefasst stellt diese Metaanalyse fest, dass IL‑6 rs1800795 und IL‑18 rs1946518 Polymorphismus das Risiko von Morbus Behcet senken. IL‑12B rs3212227 erhöht aber die Suszeptibilität von Morbus Behcet. Weitere großangelegte Untersuchungen dieses Zusammenhangs sind notwendig.
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Y. Xu, K. Zhou, Z. Yang, F. Li, Z. Wang, F. Xu, and C. He state that there are no conflicts of interest.
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Xu, Y., Zhou, K., Yang, Z. et al. Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease. Z Rheumatol 75, 932–938 (2016). https://doi.org/10.1007/s00393-015-0036-4
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DOI: https://doi.org/10.1007/s00393-015-0036-4