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Systematische Literaturrecherche für die S1-Leitlinie zur sequenziellen medikamentösen Therapie der rheumatoiden Arthritis

Systematic literature research for S1 guidelines on sequential medical treatment of rheumatoid arthritis

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Zusammenfassung

Hintergrund

Ausgangspunkt der neuen S1-Leitlinie waren die 2010 erschienenen EULAR Recommendations zum Management der rheumatoiden Arthritis (RA), die nach umfangreichen systematischen Literaturrecherchen (SLR) evidenzbasiert erstellt worden sind. Die SLR wurde für die deutschen Empfehlungen aktualisiert und wird in ihrer Methodik vorgestellt.

Methodik

Die SLR wurde für den Zeitraum von Januar 2009 bis Ende August 2011 durchgeführt. Es wurden alle kontrollierten Studien eingeschlossen, die die krankheitsmodifizierende Therapie der RA hinsichtlich ihrer Wirksamkeit auf Klinik, Funktion und Struktur untersucht haben.

Ergebnisse

Von 6869 gesichteten Arbeiten wurden 138 Artikel und 56 Abstracts für die Erstellung der Leitlinie berücksichtigt. Auf einem Konsensustreffen wurden die Ergebnisse der SLR vorgestellt. Auf dieser Grundlage formulierte das Expertengremium modifizierte Empfehlungen und verabschiedete diese mittels Konsensus.

Schlussfolgerungen

Mithilfe der aktualisierten SLR konnten wesentliche neue Daten im Entscheidungsprozess für die neue S1-Leitlinie zur medikamentösen Therapie der RA berücksichtigt werden.

Abstract

Background

On behalf of the German association of Rheumatology national experts developed guidelines for the medical treatment of rheumatoid arthritis (RA) based on the EULAR recommendations for the management of RA published in 2010. Current evidence was provided with an update of the systematic literature review (SLR). The methods and results of the SLR are presented in this article.

Materials and methods

An update of the EULAR SLR for the medical treatment of RA was performed from January 2009 to August 2011. The SLR assessed all controlled studies dealing with the outcome in clinical aspects, function and structure of disease modifying treatment of RA.

Results

Out of 6,869 screened publications, 138 articles and 56 abstracts were considered in the development of the German guidelines on the treatment of RA. A modified set of recommendations was approved in a consensus of national experts.

Conclusion

A systematic literature research provided current evidence for the German recommendations on the sequential medical treatment of RA.

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Danksagung

Die Durchführung der SLR wurde von der DGRh finanziert mit Unterstützung durch ein „unrestricted grant“ folgender korporativer Mitglieder der DGRh: Abbott GmbH & Co.KG, Chugai Pharma Marketing Ltd., Pfizer Pharma GmbH, Roche Pharma AG, Sanofi-Aventis Deutschland GmbH, UCB Pharma GmbH.

Interessenkonflikt

Der korrespondierende Autor weist für sich und seine Koautoren auf folgende Beziehungen hin: Vortragshonorare von Abbott (K.A.); Beratungstätigkeit/Vortragshonorare von Abbott, BMS, MSD, Mundipharma, Pfizer, UCB, Roche (K.K); Abbott, BMS, Chugai, MSD, Pfizer, Roche, UCB (U.M.-L.); Abbott, BMS, Chugai, MSD, Pfizer, Roche, UCB (J.W.).

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Authors and Affiliations

  1. Deutsche Gesellschaft für Rheumatologie, Köpenicker Str.48/49, 10179, Berlin, Deutschland

    K. Albrecht

  2. Praxiszentrum Rheumatologie, München, München, Deutschland

    K. Krüger

  3. Abteilung für Rheumatologie und klinische Immunologie, Justus-Liebig-Universität Giessen, Kerckhoff-Klinik, Bad Nauheim, Deutschland

    U. Müller-Ladner

  4. Klinik für Rheumatologie und klinische Immunologie, Schön Klinik Hamburg Eilbek, Hamburg, Deutschland

    J. Wollenhaupt

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  1. K. Albrecht
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  4. J. Wollenhaupt
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Correspondence to K. Albrecht.

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Albrecht, K., Krüger, K., Müller-Ladner, U. et al. Systematische Literaturrecherche für die S1-Leitlinie zur sequenziellen medikamentösen Therapie der rheumatoiden Arthritis. Z. Rheumatol. 71, 604–618 (2012). https://doi.org/10.1007/s00393-012-1048-y

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