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Janus-Kinase-Hemmer

Janus kinase inhibitors

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Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

Die Janus-Kinase-Inhibitoren stellen einen neuen therapeutischen Ansatz in der Behandlung der rheumatoiden Arthritis dar. In Phase-II- und -III-Studien zu Tofacitinib zeigte sich eine gute klinische Wirksamkeit mit einem ACR (American College of Rheumatology)-20-Ansprechen von > 50% sowohl für die Mono- als auch die Kombinationstherapie mit Methotrexat. Das Sicherheitsprofil bezüglich Infektionen ist ähnlich zu den bekannten Biologika mit einer Rate an schwerwiegenden Infektionen von 3,0/100 Patientenjahre. Die häufigsten Infektionen stellen Atemwegs- und Harnwegsinfekte dar.

Abstract

Janus protein tyrosine kinase (JAK) inhibitors are new therapeutic targets in the treatment of rheumatoid arthritis. Tofacitinib has shown good clinical efficacy in phase II and III studies with American College of Rheumatology (ACR) 20 response rates over 50% for monotherapy and in combination with methotrexate (MTX). Also the safety profile shows similar infection rates as observed with known biologicals. The crude rate of serious infection events was 3/100 patient-years. Often reported adverse events are infections of the upper respiratory tract and urogenital infections

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  1. Med. Klinik und Poliklinik II, Sektion Rheumatologie/Immunologie, Universitätsklinikum Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Deutschland

    E. Ostermeier, P. Roll & H.-P. Tony

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  1. E. Ostermeier
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  2. P. Roll
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  3. H.-P. Tony
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Correspondence to E. Ostermeier.

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Ostermeier, E., Roll, P. & Tony, HP. Janus-Kinase-Hemmer. Z. Rheumatol. 71, 473–478 (2012). https://doi.org/10.1007/s00393-011-0879-2

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  • DOI: https://doi.org/10.1007/s00393-011-0879-2

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