Skip to main content
Log in

Leitliniengerechte Diagnostik und Therapie der Osteoporose 2010

Osteoporosis diagnosis and therapy according to the 2010 guidelines

  • CME Weiterbildung · Zertifizierte Fortbildung
  • Published:
Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

Osteoporotische Knochenbrüche sind eine häufige Ursache von Einbußen an Selbständigkeit und Lebensqualität im Alter. Der Erhalt von Muskulatur und Koordination, die tägliche Zufuhr von 1000 mg Kalzium, eine ausreichende Versorgung mit Vitamin D und ein umsichtiger Umgang mit Sturz- bzw. Osteoporose-fördernden Medikamenten sind die wichtigsten Basismaßnahmen zur Frakturvermeidung. Ab einem 10-Jahres-Frakturrisiko von 30% für proximale Femurfrakturen und Wirbelkörperfrakturen empfiehlt die Leitlinie des Dachverbands Osteologie eine Langzeittherapie mit spezifischen Osteoporosemedikamenten.

Abstract

Osteoporotic fractures are a frequent cause of disability and loss of quality of life in old age. Maintaining muscle function and balance, a daily calcium intake of 1000 mg, sufficient vitamin D and prudent use of drugs associated with falls and osteoporosis are key components to fracture prevention. The German guideline recommends that a specific long-term osteoporosis medication be initiated in individuals with a 30% 10-year risk for hip fractures and vertebral fractures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Consensus Development Conference (1993) Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94:646–656

    Article  Google Scholar 

  2. Hiligsmann M, Ethgen O, Richy F et al (2008) Utility values associated with osteoporotic fracture: A systematic review of the literature. Calcif Tissue Int 82:288–292

    Article  CAS  PubMed  Google Scholar 

  3. Kanis JA, Johnell O, De Laet C et al (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375–382

    Article  CAS  PubMed  Google Scholar 

  4. Blake GM, Fogelman I (2007) Role of dual-energy x-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom 10:102–110

    Article  PubMed  Google Scholar 

  5. Tervo T, Nordström P, Neovius M et al (2008) Constant adaptation of bone to current physical activity level in men: A 12-year longitudinal study. J Clin Endocrinol Metab 93:4873–4879

    Article  CAS  PubMed  Google Scholar 

  6. Steingrimsdottir L, Gunnarsson O, Indridason OS et al (2005) Relationship between serum parathyroid hormone levels, vitamin D sufficiency and calcium intake. JAMA 294:2336–2341

    Article  CAS  PubMed  Google Scholar 

  7. Bolland MJ, Barber PA, Doughty RN et al (2008) Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 336:262–266

    Article  CAS  PubMed  Google Scholar 

  8. Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S–1086S

    CAS  PubMed  Google Scholar 

  9. Bauer DC, Ettinger B, Nevitt MC et al (2001) Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann Intern Med 134:561–568

    CAS  PubMed  Google Scholar 

  10. Orstavik RE, Haugeberg G, Mowinckel P et al (2004) Vertebral deformities in rheumatoid arthritis: a comparison with population-based controls. Arch Intern Med 164(4):420–425

    Article  PubMed  Google Scholar 

  11. Kanis JA, Johansson H, Oden A et al (2004) A metaanalysis of prior corticosteroid use and fracture risk. J Bone Miner Res 19(6):893–899

    Article  PubMed  Google Scholar 

  12. Staa TP van, Geusens P, Bijlsma JW et al (2006) Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum 54(10):3104–3112

    Article  PubMed  Google Scholar 

  13. Bianchi G, Sambrook P (2008) Oral nitrogen-containing bisphosphonates: a systematic review of randomized clinical trials and vertebral fractures. Curr Med Res Opin 24:2669–2677

    Article  CAS  PubMed  Google Scholar 

  14. DVO-Leitlinie 2009 zur Prophylaxe, Diagnostik und Therapie der Osteoporose bei Erwachsenen. Osteologie 18:304–328, http://www.dv-osteologie.org/dvo_leitlinien/dvo-leitlinie-2009

    Google Scholar 

  15. McCloskey EV, Johansson H, Oden A et al (2008) Ten-year fracture probability identifies women who will benefit from clodronate therapy-additional results from a double-blind, placebo-controlled randomised study. Osteoporos Int 20:811–817

    Article  PubMed  Google Scholar 

  16. Saag KG, Shane E, Boonen S et al (2007) Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med 357:2028–2039

    Article  CAS  PubMed  Google Scholar 

  17. Seeman E (2007) Is a change in bone mineral density a sensitive and specific surrogate of anti-fracture efficacy? Bone 41:308–317

    Article  CAS  PubMed  Google Scholar 

  18. Curtis JR, Westfall AO, Cheng H et al (2008) Risk of hip fracture after bisphosphonate discontinuation: implications for a drug holiday. Osteoporos Int 19:1613–1620

    Article  CAS  PubMed  Google Scholar 

  19. Gallagher A, Rietbrock S, Olson M et al (2008) Fracture outcomes related to persistence and compliance with oral bisphosphonates. J Bone Miner Res 23:1569–1575

    Article  PubMed  Google Scholar 

  20. Ito Z, Harada A, Matsui Y et al (2006) Can you diagnose for vertebral fracture correctly by plain X-ray? Osteoporos Int 17:1584–1591

    Article  CAS  PubMed  Google Scholar 

  21. Pfeilschifter J (2007) Schmerztherapie bei Osteoporose. Allgemeinarzt 19:32–37

    Google Scholar 

  22. Smith MR, Egerdie B, Hernández Toriz N et al (2009) Denosumab halt prostate cancer study group. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med 361(8):745–755

    Article  CAS  PubMed  Google Scholar 

  23. Cummings SR, San Martin J, McClung MR et al (2009) Freedom trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361(8):756–765

    Article  CAS  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. Braun.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Braun, J., Pfeilschifter, J. Leitliniengerechte Diagnostik und Therapie der Osteoporose 2010. Z. Rheumatol. 69, 327–339 (2010). https://doi.org/10.1007/s00393-010-0623-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00393-010-0623-3

Schlüsselwörter

Keywords

Navigation