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Erkrankungen des äußeren Auges bei rheumatoider Arthritis

Diseases of the outer eye in rheumatoid arthritis

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Zusammenfassung

Augenbeteiligungen bei rheumatoider Arthritis sind häufig und können sich klinisch als Leitsymptom dieser Erkrankung präsentieren. Alle Strukturen des Sehorgans können betroffen sein. Im Vordergrund des Erkrankungsspektrums stehen jedoch Keratoconjunctivitis sicca, Episkleritis und Skleritis sowie ulzerative Keratitiden. Pathogenetisch werden – wie für die Grunderkrankung – überwiegend autoimmunologische Reaktionen bei genetischer Prädisposition des Patienten als bedeutsam angesehen. Morphologische und physiologische Besonderheiten des Auges werden zunehmend als pathogenetisch bedeutsam für die unterschiedlichen Augenmanifestationen erkannt. Ziel dieses Beitrages ist es eine Übersicht zu Klinik, Pathogenese und Therapie okulärer Beteiligung bei rheumatoider Arthritis zu bieten.

Abstract

Eye involvement is a frequent finding in patients with rheumatoid arthritis and may represent the leading clinical manifestation of disease. In this context, all components of the visual organ might be affected. The main spectrum of eye involvement comprises keratoconjunctivitis sicca, episcleritis and scleritis as well as ulcerative keratitis. As with the underlying disease, autoimmune reactions based on a patient’s genetic predisposition are assumed to be of significance in disease pathogenesis. Emerging evidence also points to additional morphological and physiological ocular characteristics in the pathogenesis of the various ocular pathologies. This article gives an overview of clinical aspects, pathogenetic background as well as therapeutic options for ocular involvement in rheumatoid arthritis.

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Der korrespondierende Autor weist auf folgende Beziehungen hin: Beratungstätigkeit für Alcon, Allergan, Bausch & Lomb, Novartis, Thea, GmbHs.

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  1. Augenklinik, Charité-Universitätsmedizin Berlin,Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland

    E. Feist &  U. Pleyer

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  2. U. Pleyer
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Correspondence to U. Pleyer.

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Feist, E., Pleyer, U. Erkrankungen des äußeren Auges bei rheumatoider Arthritis. Z. Rheumatol. 69, 403–410 (2010). https://doi.org/10.1007/s00393-009-0577-5

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