Zusammenfassung:
Die Arthrosis deformans stellt eine verbreitete Erkrankung dar und weist in allen ethnischen Gruppen eine hohe Prävalenz auf. Alle Gelenke können betroffen sein. Genetische Faktoren beeinflussen die Entstehung. Leitsymptome der Erkrankung sind der Schmerz und die zunehmende Immobilität. Die Behandlung ist in den Anfangsstadien konservativ. Im Endstadium ist die Implantation eines Kunstgelenks, gelenkabhängig auch eine Versteifung, möglich.
Zu einer Heilung führende medikamentöse oder genetische Therapieansätze existieren noch nicht, die Forschung auf diesen Gebieten wird jedoch intensiv betrieben.
Abstract
Arthrosis deformans is a common disease worldwide with a high prevalence among all ethnic groups. All joints may be affected and genetic factors influence the onset of the disease. The main symptoms include pain and increasing immobility over the course of the illness. Treatment in early stages is conservative. In the final stages of disease the implantation of an endoprosthesis, as well as bracing depending on the joint in question, are possible.
Complete healing of the disease is not possible to date; however, medicamentous or genetic-therapy approaches are currently the subject of intensive research.
Literatur
Altman RD, Zinsenheim JR, Temple AR, Schweinle JE (2007) Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled. Osteoarthritis Cartilage 15: 454–461
Ameye LG, Chee WSS (2006) Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 8: R127
Avouac J, Gossec L, Dougados M (2007) Efficacy and safety of opioids for osteoarthritis: a meta-analysis of randomized trials. Osteoarthritis Cartilage 15: 957–965
Blom AB, Van Lent PL, Libregts S et al. (2007) Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis. Arthritis Rheum 56: 147–157
Buckland-Wright JC, Messent EA, Bingham CO III et al. (2007) A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology 46: 257–264
Davis CR, Karl J, Granell R et al. (2007) Can biochemical markers serve as surrogates for imaging in knee osteoarthritis? Arthritis Rheum 56: 4038–4047
Ding C, Cicuttini F, Blizzard L et al. (2007) A longitudinal study of the effect of sex and age on the rate of change in knee cartilage volume in adults. Rheumatology 46: 273–279
Harms S, Larson R, Sahmoun AE, Beal JR (2007) Obesity increases the likelihood of total joint replacement surgery among younger adults. Int Orthop 31: 23–26
Kafienah W, Mistry S, Dickinson SC et al. (2007) Three-dimensional cartilage tissue engeneering using adult stem cells from osteoarthritis patients. Arthritis Rheum 56: 177–187
Luyten FP, Geusens P, Malaise M et al. (2007) A prospective randomized multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip. Ann Rheum Dis 66: 99–106
Mazzuca SA, Brandt KD, Katz BP et al. (2007) Risk factors for early radiographic changes of tibiofemoral osteoarthritis. Ann Rheum Dis 66: 394–399
Molsberger A, Böwing G, Haake M et al. (2002) Akupunktur bei Erkrankungen des Bewegungsapparates. Schmerz 16: 121–128
Ralston SR (2007) Editorial: New developments in the search for genetic determinants of osteoarthritis. Osteoarthritis Cartilage 15: 117–119
Reijman M, Pols HAP, Bergink AP et al. (2007) Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam study. Ann Rheum Dis 66: 158–162
Valdes AV, Loughlin J, Van Oene M et al. (2007) Sex and ethnic differences in the association of ASPN, CALM1,COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum 56: 137–146
White A, Foster NE, Cummings M, Barlas P (2007) Acupuncture treatment for chronic knee pain: a systematic review. Rheumatology 46: 384–390
Zhai G, Hart DJ, Kato BS et al. (2007) Brief report: Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal study. Osteoarthritis Cartilage 15: 222–225
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rehart, S., Lehnert, H. Aktuelle Aspekte zur Arthrose. Z. Rheumatol. 67, 305–314 (2008). https://doi.org/10.1007/s00393-008-0304-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00393-008-0304-7