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Systemischer Lupus erythematodes und Antiphospholipidsyndrome in der Schwangerschaft

Systematic lupus erythematosus and antiphospholipid syndrome during pregnancy

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Zusammenfassung

Frauen mit systemischem Lupus erythematodes (SLE) und Antiphospholipidsyndrom (APS) können verschiedene Schwangerschaftskomplikationen erleiden, z. B. Reaktivierung des SLE, Thrombose, Fehlgeburt, Neugeborenenlupus, schwangerschaftsinduzierte Hypertonie, pulmonale Hypertonie und Arzneimitteltoxizität.

Das richtige Management dieser Patientinnen erfordert eine kombinierte geburtshilflich-medizinische Versorgung, die genaue Beobachtung des kindlichen Wachstums und Wohlergehens, eine Kontrolle der SLE-Aktivität und eine angemessene Thromboseprophylaxe. Bei guter Versorgung verlaufen die meisten Schwangerschaften von Frauen mit SLE und APS günstig.

Abstract

Women with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are subject to several complications during pregnancy, including reactivation of SLE, thrombosis, miscarriage, neonatal lupus, pregnancy-induced hypertension, pulmonary hypertension and drug toxicity.

Correct management of these patients requires combined medical-obstetric care, close surveillance of baby’s growth and well-being, control of SLE activity and correct thromboprophylaxis. With good care, most pregnancies in women with SLE and APS end successfully.

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Authors and Affiliations

  1. Service and Department of Internal Medicine, Hospital de Cruces, University of the Basque Country, Bizkaia, Spanien

    G. Ruiz-Irastorza

  2. Lupus Research Unit, the Rayne Institute, St. Thomas‘ Hospital, King’s College, London SE1 7EH, Großbritannien

    M. A. Khamashta

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  1. G. Ruiz-Irastorza
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  2. M. A. Khamashta
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Correspondence to M. A. Khamashta.

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Übersetzung: Lothar Thöne, Heidelberg.

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Ruiz-Irastorza, G., Khamashta, M.A. Systemischer Lupus erythematodes und Antiphospholipidsyndrome in der Schwangerschaft. Z. Rheumatol. 65, 192–199 (2006). https://doi.org/10.1007/s00393-006-0058-z

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  • DOI: https://doi.org/10.1007/s00393-006-0058-z

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